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Science, Volume 388, Issue 6746, Page 492-496, May 2025.

Science, Volume 388, Issue 6746, Page 477-477, May 2025.

Science, Volume 388, Issue 6746, Page 478-478, May 2025.

As evidence accrues of complex socially transmitted behaviors in animals, biologists are figuring out how to use these data in conservation

Remains recovered from beneath a Milan hospital shed light on health, diet, and drug habits during the 1600s

The one-of-a-kind initiative offered support from high school to postdoctoral levels

Fights over research spending and pending court rulings loom large

The project could bolster tribal land rights and serve as a model for partnership between scientists and Indigenous communities

Discovery could help crop breeders preserve grain quality and harvest size as climate changes

In Alzheimer's disease, amyloid beta (Aβ) and tau pathology are thought to drive synapse loss. However, there is limited information on how endogenous levels of tau, Aβ and other biomarkers relate to patient characteristics, or how manipulating physiological levels of Aβ impacts synapses in living adult human brain. Using live human brain slice cultures, we report that Aβ(1-40) and tau release levels vary with donor age and brain region, respectively. Release of other biomarkers such as KLK-6,...

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CONCLUSION: Ethnic disparities in frailty prevalence persist across community-based settings in different countries and are not fully explained by known inequalities. Addressing these disparities will likely require careful frailty measurement and assessment; confronting structural inequalities; and tailoring interventions to the needs of minoritised populations.

Conversion electrodes offer higher reversible capacity and lower cost than conventional intercalation chemistry electrodes, but suffer from kinetic limitation and large volume expansion. Despite significant efforts, developing conversion electrodes with fast charging capability and extended lifespan remains challenging. Here, by leveraging the advantages of high-entropy doping and morphology tailoring, we develop a high-entropy hierarchical micro/nanostructured sulfoselenide...

Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4^(+) T cells that accumulate with aging. These age-associated T cells are emerging as relevant players in the onset of inflammaging and tissue senescence. Here, based on information provided by single-cell RNA sequencing data, we present a flow cytometry panel that allows the identification of age-associated T cell subsets in systematic larger analysis in mice. We use this panel to evaluate at...

Marine plastic pollution is a global issue, with microplastics (1 µm-5 mm) dominating the measured plastic count^(1,2). Although microplastics can be found throughout the oceanic water column^(3,4), most studies collect microplastics from surface waters (less than about 50-cm depth) using net tows⁵. Consequently, our understanding of the microplastics distribution across ocean depths is more limited. Here we synthesize depth-profile data from 1,885 stations collected between 2014 and 2024 to...

During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania¹. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin America, while the prevalence in early industrialized regions continued to grow steadily^(2-4). Changes in the incidence and prevalence denote the evolution of IBD across four epidemiologic stages: stage 1...

Oncogenic mutations are widespread in normal human tissues¹. Similarly, in murine chimeras, cells carrying an oncogenic lesion contribute normal cells to adult tissues without causing cancer^(2-4). How lineages that escape cancer via normal development differ from the minority that succumb is unclear. Tumours exhibit characteristic cancer hallmarks; we therefore searched for hallmarks that differentiate cancer-prone lineages from resistant lineages. Here we show that total cell cycle duration...

To examine the association between body mass index (BMI) trajectories, early and recent BMI changes, and phenotypic age acceleration (PhenoAgeAccel), addressing inconsistent findings in previous studies on weight change and aging. Data from the National Health and Nutrition Examination Survey from 2005 to 2018 were used, selecting participants aged 50 years and older. A growth mixture model was employed to identify BMI trajectories. The association between different BMI trajectories and...

CONCLUSIONS: Three distinct LSM trajectory patterns, each with unique demographic and clinical characteristics, were identified. Because older cancer survivors have distinct LSM patterns, interventions should be tailored to address specific characteristics and clinical needs. LSM measurement can contribute to assessment of older adults generally and should become part of standard assessment in older cancer survivors.

CONCLUSIONS: The location of caregiving, and caregiver's age and gender play an important role for changes in grip strength. The findings suggest that caregiving outside the household might be helpful for grip strength, in particular for older and male adults. Older caregivers inside the household, however, seem to need more support to prevent further decline in grip strength.