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Microglia activation orchestrates CXCL10-mediated CD8(+) T cell recruitment to promote aging-related white matter degeneration
Aging is the major risk factor for neurodegeneration and is associated with structural and functional alterations in white matter. Myelin is particularly vulnerable to aging, resulting in white matter-associated microglia activation. Here we used pharmacological and genetic approaches to investigate microglial functions related to aging-associated changes in myelinated axons of mice. Our results reveal that maladaptive microglia activation promotes the accumulation of harmful CD8^(+) T cells,...
IADL for identifying cognitive impairment in Chinese older adults: insights from cross-lagged panel network analysis
CONCLUSIONS: This study provides new insights into the associations between specific IADL activities and cognitive function domains among Chinese older adults. Concentrate on monitoring limitations related to "Use public transit," "Make food" and "Walk 1 km," and promoting broader life-space mobility may be beneficial to preventing the decline of cognitive function. The findings underscore the importance of targeting interventions not only by specific cognitive domains, but also potentially by...
Correction for Masliah et al., beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
No abstract
Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice
Stiffening of the aorta is a key antecedent to cardiovascular diseases (CVD) with aging. Age-related aortic stiffening is driven, in part, by cellular senescence-a hallmark of aging defined primarily by irreversible cell cycle arrest. In this study, we assessed the efficacy of 25-hydroxycholesterol (25HC), an endogenous cholesterol metabolite, as a naturally occurring senolytic to reverse vascular cell senescence and reduce aortic stiffness in old mice. Old (22-26 months) p16-3MR mice, a...
Older Adults Without Family Caregivers Need Better Access to Medicaid Support Services
Changes to improve waiver access to adults aging solo.
Food-washing monkeys recognize the law of diminishing returns
Few animals have the cognitive faculties or prehensile abilities needed to eliminate tooth-damaging grit from food surfaces. Some populations of monkeys wash sand from foods when standing water is readily accessible, but this propensity varies within groups for reasons unknown. Spontaneous food-washing emerged recently in a group of long-tailed macaques (Macaca fascicularis) inhabiting Koram Island, Thailand, and it motivated us to explore the factors that drive individual variability. We...
Physical Activity Modifies the Metabolic Profile of CD4<sup>+</sup> and CD8<sup>+</sup> T-Cell Subtypes at Rest and Upon Activation in Older Adults
T-cell metabolism is a key regulator of immune function. Metabolic dysfunction in T cells from young mice results in an aged phenotype, accelerating immunosenescence. Physical activity (PA) maintains T-cell function and delays immunosenescence in older adults, but the underlying mechanisms are poorly understood. We investigated the effects of PA on the metabolic and functional profiles at a single-cell resolution of resting and stimulated T cells from young adults (N = 9, 23 ± 3 years) and...
Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial
BACKGROUND: We examined the efficacy of physical exercise with nutritional lectures in preventing cognitive decline among older adults.
Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative condition associated with aging. As the population ages, the incidence of AD has risen annually, making it the fourth leading cause of death, following cardiovascular disease, cancer, and stroke. The main pathological features of AD are now thought to include the accumulation of extracellular amyloid-β (Aβ) plaques, the formation of intracellular neurofibrillary tangles, and a reduction in synaptic connections in the cerebral cortex and...
Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network)
CONCLUSION: The comprehensive clinical use of multiple laboratory biomarkers can contribute both to the early identification of trajectories of cognitive and functional decline in older adults, and to the identification of mechanisms underlying the effect of multidisciplinary interventions on age-related pathological processes.
Daily briefing: Earth’s core could be leaking
Nations urged to ‘pick up the ball’ after DEI research cuts
Scientific conferences are leaving the US amid border fears
This ancient pathogen became deadlier when humans started wearing wool
‘Landmark’ evolution study shows how rice inherits tolerance to cold without DNA changes
These contact lenses give people infrared vision — even with their eyes shut
Rare ‘spider star’ spotted consuming its companion
Publisher Correction: Imaging surface structure and premelting of ice Ih with atomic resolution
Signatures of chiral superconductivity in rhombohedral graphene
Erratum for the Report “Directly visualizing the momentum-forbidden dark excitons and their dynamics in atomically thin semiconductors” by Julien Madéo et al.
Science, Volume 388, Issue 6749, May 2025.