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New discovery confirms the long-debated hypothesis that the ancient winged reptiles ate plants

Scientists sequence 20-million-year-old enamel protein from teeth fossils preserved in Arctic cold

Aging heterogeneity in tissue-regenerative cells leads to variable therapeutic outcomes, complicating quality control and clinical predictability. Conventional analytical methods relying on labeling or cell lysis are destructive and incompatible with downstream therapeutic applications. Here we show a label-free, nondestructive single-cell analysis platform based on nanosensor chemical cytometry (NCC), integrated with automated hardware and deep learning. nIR fluorescent single-walled carbon...

Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and...

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Cell cycle regulation, aging, and metabolism are pivotal biological processes linked to both normal physiology and disease development. Understanding their interplay is crucial for advancing gerontological research and clinical oncology. We analyzed articles and reviews on the cell cycle, aging, and metabolism from 2004 to 2023 using the Web of Science Core Collection. Bibliometric tools, VOSviewer, and CiteSpace, were applied to visualize collaboration networks, geographic distributions, and...

CONCLUSIONS: Older adults' experiences of existential group treatment suggest that engaging in existential dimensions of aging can be helpful when done in a structured setting together with others. Reduced experiential avoidance, increased determination to do what feels meaningful, relational aspects as well as one's own commitment to therapy can help explain how existential group treatment may contribute to change among older adults with psychological distress.

CONCLUSION: The study underscores the importance of considering both direct and indirect effects in understanding the pathways through which early life experiences influence nutritional status in old age. The unexpected finding regarding the direct effect of childhood conditions on overweight in the Indian context raises important questions about the complexities of nutrition and health in this population.

BACKGROUND: Ageing is a heterogeneous process, which is associated with heterogeneous resilience in older people. Cancer surgery and treatment may be associated with accelerated ageing in some older people; studying this process will improve understanding to enable treatments to prevent adverse effects on physical and cognitive function.

CONCLUSIONS: Studies have shown that the social participation and sleep quality of older people in China can mediate the connection between urinary incontinence and subjective well-being. Therefore, it is necessary to pay timely attention to and intervene in the social participation and sleep quality of older patients with urinary incontinence to improve their subjective well-being.

Parkinson's disease-associated α-synuclein impairs autophagy by hijacking the cell's acetylation machinery.

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Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans.

As the European Union undergoes a demographic shift toward an aging population, the rising prevalence of age-related diseases poses significant public health challenges. Across the EU, disparities in health indicators and life expectancies highlight the urgency of addressing factors that contribute to unhealthy aging. Burnout, characterized by emotional, physical, and mental exhaustion, has emerged as a critical determinant of healthy aging, with profound biological, psychological, and social...

Individual imaging and fluid biomarkers provide insights into specific components of brain health, but integrated multimodal approaches are necessary to capture the complex, interrelated biological systems that contribute to brain homeostasis and neurodegenerative disease. Using data from the Brain and Cognitive Health (BACH) cohort study (N = 127; mean age = 67 years, 68% women), we performed an exploratory factor analysis to identify latent constructs of brain health. We included multimodal...