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Osteoarthritis (OA) is a common and debilitating joint disorder, with its pathogenesis significantly influenced by factors such as aging and obesity. A critical aspect of OA development is the senescence of chondrocytes, which is characterized by irreversible cell cycle arrest and the secretion of pro-inflammatory molecules, collectively known as the senescence-associated secretory phenotype (SASP). Senescent chondrocytes compromise the maintenance of the extracellular matrix (ECM) and...

CONCLUSIONS: The findings suggest that NUSN4 levels detected in the blood could serve as a potential biomarker for ovarian aging. This provides new insights into the role of mitochondrial dysfunction in reproductive age-related traits and may inform future targeted interventions to slow ovarian aging.

Respiratory syncytial virus (RSV) causes severe respiratory disease in infants and the elderly. However, natural infection fails to induce durable immune protection, and existing mRNA vaccines for older adults exhibit limited long-term efficacy. We developed an antigen engineering strategy inserting ESCRT/ALIX-binding region (EABR) into truncated RSV prefusion F (PreF) cytoplasmic tails to form enveloped virus-like particles (eVLPs). In murine models, PreF-EABR mRNA vaccines elicited higher,...

CONCLUSION: This study highlights the important impact of physical activity and body shape management on sleep disorders in older CMM patients.

ObjectivesUnited States (U.S.) immigrants are rapidly aging, although little is known on how acculturation influences their disability risk.MethodsWe pooled 2000-2018 data (n = 50,075) from the National Health Interview Survey (NHIS) to examine odds of activities of daily living (ADL) disability among middle aged (40-64) and older (65+) immigrants based on three acculturation indicators while accounting for various measures.ResultsAmong middle aged immigrants, citizenship was associated with...

The country also leads in patent filings and the number of AI researchers

Suggestions that nation’s Indigenous Māori wholeheartedly back project draws criticism

In this issue of Cell, Harris et al. reveal that high-molecular-weight soluble tau-rather than amyloid-beta-impairs burst firing in hippocampal neurons, providing a mechanistic link to cognitive decline in Alzheimer's disease. This disruption, linked to CaV2.3 downregulation, highlights soluble tau as a key driver of neuronal dysfunction and a promising therapeutic target.

Brain age and epigenetic age (DNAmAge) are 'biological clocks' independently linked to health outcomes. However, the relationship between brain and epigenetic age remains unclear. We used path analysis to investigate relationships between chronological age, DNAmAge, and brain age and explored whether advanced aging in specific brain regions relates to DNAmAge. BrainAge (global and regional) was estimated from brain MRI in 149 participants (ages 20-80). From whole blood, four DNAmAges were...

CONCLUSIONS AND IMPLICATIONS: Findings underscore differences in how LTSS availability and variety relate to unmet care needs for Black and White older adults. Future research should examine these associations in other racial and ethnic minoritized groups.

CONCLUSIONS AND IMPLICATIONS: A substantial subgroup of older Medicare beneficiaries, including both those with and without Medicaid, received paid family care between 2011 and 2022. Especially given direct care workforce shortages, evidence-based expansion of models of paid family care is an important approach to meet the care needs of older adults living in the community.

As human life expectancy continues to rise, ageing and age-related diseases have become critical societal challenges, driving extensive research across genetics, molecular biology, biochemistry, and behavioral sciences. In this context, domestic dogs (Canis lupus familiaris) offer a unique model for ageing research due to their shared environmental exposures with humans, diverse genetic profiles, and relatively short lifespans. This review aims to identify potential biomarkers of ageing in dogs,...

Model organisms such as yeast, worms, flies, and mice were key to discovering genes and other factors controlling life span and directly improved our understanding of human aging. Today, genomic tools allow study of a broader range of species, including those with short or long life spans, closely related species with different aging rates, or differences in interspecies aging. Models such as killifish, bats, and ants have much to teach us about human aging. They also reveal a flexible...

Mitochondria are no longer viewed solely as ATP- or metabolite-generating organelles but as key regulators of cellular signaling that shape physiologic aging. Contrary to earlier theories linking aging to mitochondrial DNA mutations and oxidative damage, current evidence shows that these factors do not causally limit physiologic aging. Instead, an evolving literature links age-related loss of mitochondrial signaling and function to important physiologic changes of aging. Moreover, mild...

Caenorhabditis elegans has been at the forefront of research on mechanisms of age-related decline for the past 30 years. Despite its popularity in longevity research, C. elegans is underappreciated for its potential to study complex behaviors and the progressive decline in these functions with age. Using assays of learning and memory, we have identified genetic pathways that regulate these behaviors and identified new mechanisms to boost these functions with age in both worms and mice. Because...

Aging is the greatest risk factor for most diseases. We propose that aging manifests as disease as a function of tumor-suppressive capabilities. Adequate tumor suppression results in cell death or an accumulation of damaged cells leading to inflammation and tissue dysfunction that underlies diseases such as cardiovascular disease, neurodegenerative diseases, or type 2 diabetes. Conversely, inadequate tumor suppression leads to cancer. Telomeres are central to this process because they oppose...

The past 40 years have witnessed significant progress in aging research. Although aging was once considered a stochastic process, it is now understood to be regulated by pathways and processes that can be dissected with modern cellular and molecular biology approaches. The aberrant accumulation of cells undergoing cellular senescence and an increase in chronic, sterile inflammation are two of those aging hallmarks. Here we discuss how these processes are connected and how the relationship...

The unstable electrolyte-electrode interface and the trace H(2)O in commercial organic electrolytes critically limit the cycling life of batteries. Herein, a locking-chain sodium 4,4'-(1,4-phenylenebis(oxy))-bis(butane-1-sulfonate)-15-crown-5 (15PBS) is designed for phase-to-interface electrolyte optimization. In the electrolyte phase, the strong hydrophilic sulfonate groups and 15-crown-5 in 15PBS effectively transform H(2)O from a reactive aggregated state (strong H-bond) into an inactive...

African turquoise killifish (Nothobranchius furzeri) is the shortest-lived vertebrate that can be bred in captivity, making it an ideal model organism for aging studies. However, whether the animal can be used for studying cardiac aging and whether cellular senescence contribute to this ageing process remain unclear. Here, we conducted a longitudinal study on the GRZ strain, aiming to identify phenotypic and functional markers for cardiac aging. We found that cardiac ageing in GRZ fish can be...

There is robust evidence that senescence can be propagated in vitro through mechanisms including the senescence-associated secretory phenotype, resulting in the non-cell-autonomous induction of secondary senescence. However, the induction, regulation and physiological role of secondary senescence in vivo remain largely unclear. Here we generated senescence-inducible mouse models expressing either the constitutively active form of MEK1 or MKK6 and mCherry, to map primary and secondary senescent...