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Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes
Advanced Glycation End (AGE) products are one such factor that accumulates during aging and age-related diseases. However, how exogenous AGE compounds cause aging is an area that needs to be explored. Specifically, how an organ undergoes aging and aging-related phenomena that need further investigation. The intestine is the most exposed area to food substances. How AGEs affect the intestine in terms of aging need to be explored. Drosophila melanogaster, a well-known model organism, is used to...
Retirement, Social Engagement, and Post-Retirement Changes in Cognitive Function
OBJECTIVES: This study examines whether social engagement at the time of retirement is associated with better cognitive function and slower cognitive decline.
Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain
INTRODUCTION: We investigated the neural correlates of cognitive decline in visual word perception from the perspective of intrinsic brain networks.
ISLAND Campus: a fee-free formal university educational intervention in mid- to later-life to reduce modifiable risk factors for dementia and improve cognition
INTRODUCTION: Previous research has tended to focus on early-life education for dementia risk reduction, yet there are great gains for building cognitive reserve in mid- to later-life through educational interventions. ISLAND (Island Study Linking Ageing and Neurodegenerative Disease) Campus offered free university study to all ISLAND participants, with flexible in-person/online learning models to remove educational, socioeconomic and geographical barriers. Here the core hypothesis of ISLAND...
Could thunderstorms be exaggerating the strength of mysterious gamma rays from outer space?
Storms may be confounding measurements at high-altitude observatories of the universe’s highest energy light
Build your own receptor: modular system can be tailored to any antigen
Daily briefing: Explore 2024 with Leif Penguinson
Is political interference causing faculty brain drain in the southern United States?
Can novelty scores on papers shift the power dynamics in scientific publishing?
Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson’s disease could soon be here
That Christmas jumper is a marvel of complicated physics
Behind the scenes of <i>Nature</i> News & Views in 2024
I create routes through trees to help stop howler monkeys being electrocuted by power lines
A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids
Science, Volume 386, Issue 6728, December 2024.
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice
Science, Volume 386, Issue 6728, December 2024.
Quantifying the global biodiversity of Proterozoic eukaryotes
Science, Volume 386, Issue 6728, December 2024.
Cellular RNA interacts with MAVS to promote antiviral signaling
Science, Volume 386, Issue 6728, December 2024.
U.S. science funding agencies roll out policies on free access to journal articles
NIH and DOE are first to act, with implementation by all set to begin by end of 2025
Some whales may live nearly twice as long as believed—if we let them
Study extends lifespan estimate for one whale species and suggests researchers have been underestimating others as well
U.S. scientists brace for looming government shutdown
House Republicans walk away from spending deal after Trump objects to its scope