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CONCLUSION: Older adults who are homebound face multifaceted challenges that require integrated, multidisciplinary, home-based care approaches. Expanding home-based primary and palliative care, addressing unmet care needs, and providing caregiver support are critical priorities among countries with aging populations. Future research should focus on home-based healthcare delivery models and targeted interventions to address gaps in mental health services, cognitive assessment and management, and...

Strategies to slow the aging process or mitigate its consequences on health rely on the validation of minimally-invasive biomarkers of aging that can be used to track aging and test the effectiveness of antiaging interventions. Study of aging in a nonhuman primate species offers a robust translational approach to achieving these aims, avoiding wide differences in genetics and environmental exposures that confound human aging studies. As epigenetic age appears to predict biological aging,...

Dietary protein is a key regulator of healthy aging in both mice and humans. In mice, reducing dietary levels of the branched-chain amino acids (BCAAs) recapitulates many of the benefits of a low protein diet; BCAA-restricted diets extend lifespan, reduce frailty, and improve metabolic health, while BCAA supplementation shortens lifespan, promotes obesity, and impairs glycemic control. Recently, high protein diets have been shown to promote cellular senescence, a hallmark of aging implicated in...

Elite sports have become increasingly professionalized and personalized, with soccer players facing a high number of games per season. This trend presents significant challenges in optimizing training for peak performance and requires rigorous monitoring of athletes to prevent overload and reduce injury risks. The emerging field of epigenetic clocks offers promising new pathways for developing useful biomarkers that enhance training management. This study investigates the effects of intense...

Puzzling objects spotted by NASA’s JWST telescope may be entirely new class of celestial entity

Infecting marine plankton, the pathogen may use its extreme appendage to enter host cells

CONCLUSION: The high prevalence underscores the need for routine screening in health centers and caregiver education programs.