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C-terminal amides mark proteins for degradation via SCF–FBXO31
Warming and cooling catalyse widespread temporal turnover in biodiversity
Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase
SARS-CoV-2 evolution on a dynamic immune landscape
Methanol transfer supports metabolic syntrophy between bacteria and archaea
Engineered heart muscle allografts for heart repair in primates and humans
Strange flashes from ancient galaxy deepen mystery of fast radio bursts
How flight helped bats become invincible to viruses
Molecular basis of vitamin K driven γ-carboxylation at membrane interface
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells
Author Correction: Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases
Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
Want to get a species protected? Publish in a small, niche journal
Robert F. Kennedy Jr. faces Democratic fire on vaccine record at nomination hearing
No clear opposition from Republicans to HHS nominee, who promises “unbiased gold standard science”
Should India expand push for gas stoves? Health study finds few benefits, complicating picture
Nation has been trying to phase out smoky traditional stoves that burn wood and dung
Polar bear fur has a built-in deicing feature
An analysis of the Arctic animals’ fur reveals chemical clues to how they stay ice-free
Banished from world’s biggest physics lab, Russian scientists look inward—and to China
Breakdown of collaboration with CERN forcing many physicists to reorient work
Analysis of TEM micrographs with deep learning reveals APOE genotype-specific associations between HDL particle diameter and Alzheimer's dementia
High-density lipoprotein (HDL) particle diameter distribution is informative in the diagnosis of many conditions, including Alzheimer's disease (AD). However, obtaining an accurate HDL size measurement is challenging. We demonstrated the utility of measuring the diameter of more than 1,800,000 HDL particles with the deep learning model YOLOv7 (you only look once) from micrographs of 183 HDL samples, including patients with dementia or normal cognition (controls). This method was shown to be more...
Diverse pathways for the treatment of Parkinson's disease: Integration and development of traditional and emerging therapies
Parkinson's disease (PD) is the second most common central neurodegenerative disease in the world after Alzheimer's disease (AD), which mainly occurs in middle-aged and elderly people, and is increasing with the aging of the population. With the increasing incidence of PD, it is particularly important to explore its pathology and provide effective interventions and treatments. The pathogenesis of PD involves a variety of factors such as genetics, environment, and age, and is not yet fully...