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Effectiveness of community-based health education on modifiable risk factors for Alzheimer's disease among older adults: a scoping review

7 months 2 weeks ago
A scoping review of community health education studies for dementia prevention was conducted to clarify the form, content, outcome indicators, evaluation tools, and effects of community health education interventions for dementia prevention and to inform future research in this area. This scoping review of community-based health education interventions for Alzheimer's disease prevention across eight databases identified five intervention approaches-culturally adapted interventions, health...
Ziliang Hao

Δ133p53α-mediated inhibition of astrocyte senescence and neurotoxicity as a possible therapeutic approach for neurodegenerative diseases

7 months 2 weeks ago
Non-neuronal glial cells in the brain, such as astrocytes, play essential roles in maintaining the functional integrity of neuronal cells. A growing body of evidence suggests that cellular senescence of astrocytes, characterized by loss of proliferative potential and secretion of neurotoxic cytokines, makes significant contribution to neurotoxicity in Alzheimer's disease and a wide range of other neurodegenerative diseases. This review discusses the beneficial effects of Δ133p53α, a natural p53...
Izumi Horikawa