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Blood of man who’s had 200 snake bites helps make a potent antivenom
Author Correction: Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning
Life-course approaches are needed to foster equitable healthy aging
Walking in two worlds: how an Indigenous computer scientist is using AI to preserve threatened languages
Star ecologist ‘blurred boundaries’ in lab — but colleagues criticize investigation
Trump gutted two landmark environmental reports — can researchers save them?
AI scientist ‘team’ joins the search for extraterrestrial life
Searching for dark photons in the Sun’s atmosphere
Fungus from the human gut slows liver disease in mice
‘Borders on the insane’: New NIH policy on funding foreign scientists stirs outrage
Agency will make researchers outside United States seek grants of their own rather than “subawards” from U.S. scientists
Trump’s proposed budget would mean ‘disastrous’ cuts to science
Key research budgets would shrink by one-third to one-half in 2026 spending plan
Researchers slam HHS report on gender-affirming care for youth
Critics say the report, which declines to disclose its authors, contradicts decades of scientific research
NSF becomes third U.S. science agency to propose smaller overhead payments to universities
Courts have blocked attempts by NIH and DOE to impose a flat 15% rate for reimbursement
Astronomers spot a gold mine in massive cosmic flares
Phenomenon behind heavy element creation has been a mystery for 2 decades
Dying coral reefs could slow climate change
Dissolving skeletons would boost oceans’ ability to soak up carbon dioxide
U.S. scientists’ lives and careers are being upended. Here are five of their stories
As the second Trump administration sends U.S. science into upheaval, countless researchers are fighting for their futures
Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1<sup>+</sup> microglia
Microglia and border-associated macrophages (BAMs) are critical for brain health, and their dysfunction is associated to disease. Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Here, we demonstrate that monocytes can efficiently replace all brain macrophages. Monocytes readily replaced embryonal BAMs upon their depletion and engrafted as monocyte-derived microglia (Mo-Microglia) upon more sustained niche availability. Mo-Microglia expanded comparably...
CLU alleviates Alzheimer's disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer's disease (AD), yet its precise molecular impact remains unclear. Through unbiased proteomic profiling and functional validation in CLU-deficient astrocytes, we identify increased nuclear factor κB (NF-κB)-dependent signaling and complement C3 secretion. Reduction of astrocyte CLU induced microglia-dependent modulation of extracellular apolipoprotein E (APOE) and phosphorylated tau, as well as increased microglial...
Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein's function and dysfunction in Parkinson's disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor for synucleinopathy, and ~15% of synaptic vesicle proteins have been linked to central nervous system diseases. Yet, age- and disease-induced changes in synaptic vesicles remain unexplored. Via systematic analysis of synaptic vesicles at the...
Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1<sup>+</sup> microglia
Microglia and border-associated macrophages (BAMs) are critical for brain health, and their dysfunction is associated to disease. Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Here, we demonstrate that monocytes can efficiently replace all brain macrophages. Monocytes readily replaced embryonal BAMs upon their depletion and engrafted as monocyte-derived microglia (Mo-Microglia) upon more sustained niche availability. Mo-Microglia expanded comparably...