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Psilocybin’s lasting action requires pyramidal cell types and 5-HT<sub>2A</sub> receptors
A RISC-V 32-bit microprocessor based on two-dimensional semiconductors
Millimetre-scale bioresorbable optoelectronic systems for electrotherapy
Metal–support frontier orbital interactions in single-atom catalysis
Formation and composition of Earth’s Hadean protocrust
Near-field photon entanglement in total angular momentum
Bifidobacteria support optimal infant vaccine responses
Mastering diverse control tasks through world models
A natural experiment on the effect of herpes zoster vaccination on dementia
Photoinduced copper-catalysed deracemization of alkyl halides
World’s tiniest pacemaker could revolutionize heart surgery
Do smartphones and social media really harm teens’ mental health?
Are screens harming teens? What scientists can do to find answers
What if human blood were toxic to mosquitoes? A drug can make it so
Why NIH labs have no supplies and April fooling at CDC: Trump Tracker
Follow President Donald Trump’s impact on U.S. research and science globally
Lawsuit aims to overturn many NIH grant terminations
Multiple groups and NIH-funded scientists challenge agency’s decision as arbitrary and capricious
Unusual dinosaur tracks in Scotland reveal an ancient watering hole
The impressions, once considered fish burrows, were found along a shoreline with a notable role in Scottish history
Stellarators, once fusion’s dark horse, hit their stride
Multiple companies aim to generate power by corraling plasma with twisted magnets
Molecular pathways and diagnosis in spatially resolved Alzheimer's hippocampal atlas
We employed Stereo-seq combined with single-nucleus RNA sequencing (snRNA-seq) to investigate the gene expression and cell composition changes in human hippocampus with or without Alzheimer's disease (AD). The transcriptomic map, with single-cell precision, unveiled AD-associated alterations with spatial specificity, which include the following: (1) elevated synapse pruning gene expression in the fimbria of AD, with disrupted microglia-astrocyte communication likely leading to disorganized...
The absence of Pitx3 results in postnatal loss of dopamine neurons and is associated with an increase in the pro-apoptotic Bcl2 factor Noxa and cleaved caspase 3
Mesodiencephalic dopamine neurons (mdDA) of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) play critical roles in regulating movement and motivation. Pitx3 is an essential transcription factor required for proper embryonic development and terminal differentiation of mdDA neurons. Although Pitx3 is expressed in every mdDA neuron, its ablation results only in the absence of the SNc, not the VTA. The developmental stage at which the loss of SNc first becomes apparent, as...