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Peter Lax obituary: mathematician who pioneered computer-based solutions to real-world problems
Dementia is deadly — the UN needs to take it more seriously
How to spot suspicious papers: a sleuthing guide for scientists
Mathematics in ancient Egypt
Silicate clouds and a circumplanetary disk in the YSES-1 exoplanet system
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease
Senescence-related proteins in blood predict aging traits
How to speak to a vaccine sceptic: research reveals what works
Greening nickel extraction requires institutional and financial support
Reduced investment in universities has multifaceted effects
Not all clinical data in the United States are fragmented
This tiny device spins blood clots away
Making concrete sustainable globally requires technology transfer
Senators press NIH director on killed grants and proposal to slash agency’s funding
Jay Bhattacharya says NIH’s final budget will be a “collaboration”
Trump’s proposed cut to giant physics experiment could snuff out new form of astronomy
Degrading LIGO’s observations of gravitational waves would amount to “killing a newborn baby,” one astrophysicist says
Science’s reform movement should have seen Trump’s call for ‘gold standard science’ coming, critics say
Efforts to improve the rigor of research may have unwittingly handed the administration a way to attack science
RFK Jr.’s purge of CDC vaccine advisers prompts outrage
Health secretary will soon name new members to expert group that recommends shots
Alzheimer disease in Down syndrome linked to APOE
No abstract
Evaluating EEG complexity and spectral signatures in Alzheimer's disease and frontotemporal dementia: evidence for rostrocaudal asymmetry
Accurate classification of neurodegenerative disorders remains a challenge in neuroscience. Using open-source electroencephalography (EEG) data, we investigated electrophysiological signatures to differentiate frontotemporal dementia (FTD) from Alzheimer's disease (AD) via complexity measures. Traditional relative band power analysis showed consistent increases in lower-frequency activity but did not distinguish the two disorders after correction. In contrast, fractal dimension and long-range...
Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice
Genome-wide association studies have identified many gene polymorphisms associated with an increased risk of developing late-onset Alzheimer's disease (LOAD). Many of these LOAD risk-associated alleles alter disease pathogenesis by influencing innate immune responses and lipid metabolism of microglia (MG). Here we show that boosting the expression of angiotensin-converting enzyme (ACE), a genome-wide association study LOAD risk-associated gene product, specifically in MG, reduces amyloid-β (Aβ)...