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A multilingual guide to slowing aging
No abstract
Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries
Aging trajectories are influenced by modifiable risk factors, and prior evidence has hinted that multilingualism may have protective potential. However, reliance on suboptimal health markers, small samples, inadequate confounder control and a focus on clinical cohorts led to mixed findings and limited applicability to healthy populations. Here, we developed biobehavioral age gaps, quantifying delayed or accelerated aging in 86,149 participants across 27 European countries. National surveys...
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways
Gut microbes play a crucial role in modulating host lifespan. However, the microbial factors that influence host longevity and their mechanisms of action remain poorly understood. Using the expression of Caenorhabditis elegans FAT-7, a stearoyl-CoA 9-desaturase, as a proxy for lifespan modulation, we conduct a genome-wide bacterial mutant screen and identify 26 Escherichia coli mutants that enhance host lifespan. Transcriptomic and biochemical analyses reveal that these mutant diets induce...
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Engineering chronological lifespan toward a robust yeast cell factory
Metabolic rewiring helps to construct efficient microbial cell factories; however, these cells suffer from metabolic stress during long-term fed-batch fermentation. Thus, the construction of robust cells is vital for industrial application of microbial cell factories at the laboratory scale. Here, we systematically characterized longevity factors and pathways for biosynthesis of the diterpenoid sclareol and found that weakening nutrient-sensing pathways and enhancing mitophagy synergistically...
Neither inaccurate nor biased in later life: Age-related differences in the accuracy and bias of facial trustworthiness judgment
People tend to form impressions of others' trustworthiness based on their facial appearance and make trust-related decisions accordingly. In such face-based trustworthiness judgments (FBTJs), older adults are generally more likely than younger adults to attribute higher trustworthiness. This pattern is sometimes referred to as positivity bias and has been proposed as a potential risk factor for fraud victimization in later life. However, previous studies lack objective ground-truth measures of...
Canadian government kills ostriches afflicted by H5N1 despite appeal from RFK Jr.
Culling proceeds after Canada’s Supreme Court ends heated 11-month battle over the fate of more than 300 birds