Aggregator
Mirodenafil improves cognitive function by reducing microglial activation and blood-brain barrier permeability in ApoE4 KI mice
INTRODUCTION: Alzheimer's disease (AD) has significant public health concerns in the aging society. AD can compromise brain function and lead to severe neurological abnormalities associated with dementia. The human Apolipoprotein E (ApoE4) gene is a strong risk factor for AD. However, comprehensive analyses and improvements of mouse models expressing ApoE4 remain largely unexplored.
Will your car hit that deer? Depends on your headlight bulbs—and the deer’s personality
Halogen bulbs more reliably catch deer’s attention, but whether the animals flee or freeze comes down to individual temperament
Final NSF budget proposal jettisons one giant telescope amid savage agencywide cuts
Trump’s 57% proposed cut to agency would drop grant success rates to 7% and gut education and training
‘Devastating’: NIH cancels future funding plans for HIV vaccine consortia
Researchers decry agency’s decision just as new leads reinvigorate search for long-sought vaccine
Daily briefing: The sweet smell of outer space
NIH grant cuts will axe clinical trials abroad — and could leave thousands without care
See the Milky Way dazzle during a lunar eclipse — May’s best science images
Gender equality in research publishing is a responsibility for everyone
CRISPR helps to show why a boy felt no pain
Underwater kelp forests are losing a turf war
Pace of aging matters for healthspan and lifespan in older adults
Salary negotiations: a guide for scientists
Audio long read: Three ways to cool Earth by pulling carbon from the sky
US–China tariff war threatens global public health
Dozens of active and planned NASA spacecraft killed in Trump budget request
Proposal would end nearly all new major science missions
NIH funding policy deals new blow to HIV-related trial networks
Halt to foreign “subawards” disrupts ongoing global studies and has researchers scrambling to fulfill ethical obligations to trial volunteers
Trump officials downplay fake citations in high-profile report on children’s health
References to phantom studies comes after White House pledge to practice “gold standard” science
Clearest ever images of Sun’s corona reveal ‘raindrops’ of dancing plasma
New system yields sharp views of the Sun’s mysterious outer atmosphere
Thalamic free water elevation and its association with glymphatic dysfunction in Parkinson's disease: A cross-sectional and longitudinal study
Free Water (FW) is considered an indicator of neuroinflammation, while the Index of Diffusivity along the Perivascular Space (ALPS) is a recently introduced measure of glymphatic function. However, no study has yet investigated the specific relationships between these factors simultaneously. This study aimed to examine changes in FW in the thalamic midline and lateral nuclei in Parkinson's disease (PD), with a particular focus on the potential influence of glymphatic system dysfunction. MRI data...
Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer's disease
Type 2 diabetes (T2D) is a significant risk factor for Alzheimer's disease (AD). Despite multiple studies reporting this connection, the mechanism by which T2D exacerbates AD is poorly understood. It is challenging to design studies that address co-occurring and comorbid diseases, limiting the number of existing evidence bases. To address this challenge, we expanded the applications of a computational framework called Translatable Components Regression (TransComp-R), initially designed for...