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Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue-regulated energy metabolism
Bisphenol A (BPA) substitutes are widely used as food contact materials and consumer products, while the effects of pathophysiologically relevant concentrations of BPA substitutes on aging remain unclear. In this study, we used Caenorhabditis elegans (C. elegans) to investigate the effects of five BPA substitutes [bisphenol S (BPS), bisphenol B, bisphenol F (BPF), tetramethyl BPF, and 4,4'-(Perfluoropropane-2,2-diyl)diphenol] at pathophysiologically relevant exposure levels during aging and...
Image-based identification and isolation of micronucleated cells to dissect cellular consequences
Recent advances in isolating cells based on visual phenotypes have transformed our ability to identify the mechanisms and consequences of complex traits. Micronucleus (MN) formation is a frequent outcome of genome instability, triggers extensive changes in genome structure and signaling coincident with MN rupture, and is almost exclusively defined by visual analysis. Automated MN detection in microscopy images has proved challenging, limiting discovery of the mechanisms and consequences of MN....
Sustained and reversible effects of a dietary phosphate intake on bone and mineral metabolism during aging
The loss of bone volume during aging is common in both men and women and can have substantial negative health impacts. Weakened bones can lead to fractures which in turn can result in hospitalization, decreased quality of life, and early death. The post-diagnosis treatment of osteoporosis has received the bulk of attention with less research focused on prevention and modifiable risk factors such as nutrition. Calcium and vitamin D supplementation has provided limited skeletal benefit in healthy...
A Comprehensive Multiomics Signature of Doxorubicin-Induced Cellular Senescence in the Postmenopausal Human Ovary
A major aging hallmark is the accumulation of cellular senescence burden. Over time, senescent cells contribute to tissue deterioration through chronic inflammation and fibrosis driven by the senescence-associated secretory phenotype (SASP). The human ovary is one of the first organs to age, and prominent age-related fibroinflammation within the ovarian microenvironment is consistent with the presence of senescent cells, but these cells have not been characterized in the human ovary. We thus...
Explosive mpox outbreak in Sierra Leone overwhelms health systems
Rapid transmission through sexual networks raises fears of wider spread in the region
Daily briefing: CAR-T proves its worth in hard-to-treat solid tumours
Web-scraping AI bots cause disruption for scientific databases and journals
Editing epigenetic age
How to keep astronauts healthy in deep space
How do I choose a principal investigator for my next postdoc?
Your time is valuable. Don’t give it away just for ‘exposure’
The polar regions hold crucial scientific secrets — and the time to study them is running out
Cancer-fighting CAR T cells show promising results for hard-to-treat tumours
Speeding up ginseng growth to aid drug discovery
Rare ‘ambidextrous’ protein breaks rules of handedness
National Academies, staggering from Trump cuts, on brink of dramatic downsizing
Plan for slashed units and mission to be presented at governor’s meeting next week
Trump’s proposed budget details drastic cuts to biomedical research and global health
CDC takes a bigger hit than expected; support for international HIV, malaria, TB, and vaccine efforts zeroed out
This octopus grew a ninth arm—which soon developed a mind of its own
Study highlights just how flexible cephalopod’s bodies are after injury and during recovery
Ancient poop yields world’s oldest butterfly fossils
Tiny wing scales suggest the proboscis evolved 100 million years before flowers
High-frequency repetitive transcranial magnetic stimulation upregulates BDNF expression and promotes synaptogenesis in mouse models of Parkinson's disease
Synaptic dysfunction exists before symptoms occur in Parkinson's disease, and restoring synaptic function as a promising therapeutic approach. Brain-derived neurotrophic factor serves as a key neuroregulatory factor in regulating synaptic function. Studies have shown that the protein levels of brain-derived neurotrophic factor is low in Parkinson's disease mice. However, repetitive transcranial magnetic stimulation (rTMS) can mitigate this decline. We explored the protective role of rTMS on...