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Oral functional limitation and risk of frailty onset in older adults: a sex-stratified 4-Year cohort study with competing risk analysis
CONCLUSION: Self-reported oral functional limitation was significantly associated with frailty onset over 4 years, particularly among women. Incorporating oral function assessment into geriatric screening and community health programs may facilitate early identification of risk and the implementation of preventive strategies for frailty.
DNA methylation-based epigenetic clocks highlight immune-driven aging acceleration in COVID-19 across diverse populations
The SARS-CoV-2 pandemic has affected millions worldwide, with aging being a key risk factor for severe disease outcomes. This study examines the rate of epigenetic aging, as measured by DNA methylation-based aging markers, in COVID-19 patients versus healthy individuals. We found that PCGrimAge, a next-generation epigenetic clock associated with immune dysregulation and inflammation, showed the strongest correlation with the chronological age of the European COVID-19 patients. Several other...
Mesenchymal cell-derived extracellular vesicles ameliorate age-related deficits in working memory and in vivo MRI measures of white matter structure and function in rhesus monkeys
Aging humans and non-human primates both exhibit a similar pattern of cognitive decline beginning in middle age that is characterized by progressive impairments in rule learning, executive function, and working and recognition memory-functions often associated with dysfunction of prefrontal and medial temporal lobe regions. The heterogeneity and inter-subject variability in aging and age-related cognitive impairments present challenges for developing effective therapeutics and can be attributed...
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