Aggregator
Is AI powering Big Brother? Surveillance research is on the rise
Is AI watching you? The hidden links between research and surveillance
Pioneering but overlooked 1938 fusion experiment is recreated at last
Can industry fill the gap left by US research funding cuts?
These scientists re-enacted Stone Age voyage to Japan’s remote islands
The economic effects of federal cuts to US science — in 24 graphs
Family recipe
Missile defence won’t prevent the health crises that rock global security
AI, peer review and the human activity of science
Eureka! The brain science behind lightbulb moments
Hormone helps mice live longer and avoid obesity
Federal judge orders agencies to restore grants to University of California scientists
Ruling on first class action suit reversing terminations may be expanded to entire government
In latest blow, National Science Foundation staff to be booted from their headquarters
Trump administration is giving building to housing department but has not said where science agency will go
Global warming is triggering earthquakes in the Alps
Study provides first solid link between climate change and earthquake hazard
A mammoth boomerang returns new clues about early human toolmaking
New dates for a throwing weapon found in Poland reveal it as one of the earliest of its kind
Prestigious NSF graduate fellowship tilts toward AI and quantum
Students in the life sciences are shut out of latest cohort of 500 fellows
National rare disease effort among those upended by Trump’s freeze on Harvard grants
White House battle with Ivy League school disrupts databases and networks relied on by other universities
Following court order, NIH ceases new terminations of politically sensitive grants
After a judge told agency to restore hundreds of killed grants, NIH backs off plans to cancel more existing projects
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high amyloid burden in the carrier. However, the molecular mechanisms enabling the E3S/S mutation to mitigate tau-induced neurodegeneration remain unclear. Here, we replaced mouse Apoe with wild-type human APOE3 or APOE3S/S on a tauopathy background. The R136S mutation decreased tau load and protected against tau-induced...
Granzyme K<sup>+</sup> CD8 T cells slow tauopathy progression by targeting microglia
Neurodegenerative diseases activate innate and adaptive immune responses that can either slow or accelerate disease progression. Here, we sought to define beneficial immune pressures that emerge during tauopathy development in mice and humans. Using mice that express mutant human tau in neurons, we observed that microglia slowed tauopathy development by controlling the spread of phosphorylated tau (pTau) in the central nervous system and blood. However, over time microglia converted into...