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CONCLUSIONS: We found no consistent evidence linking ageism to biological aging status. Further research should investigate why; potentially, ageism has less time to become biologically embedded, compared to racism and sexism, which might be experienced throughout one's life, but measurement challenges could also be present.

BACKGROUND: Orthopedic diseases, including osteoarthritis, osteoporosis, and age-related musculoskeletal disorders, significantly impact quality of life and are becoming increasingly prevalent with aging populations. A growing body of evidence highlights the role of cellular senescence in the pathogenesis of these conditions. Senescent cells (SCs), characterized by irreversible cell cycle arrest, accumulate in tissues over time, contributing to inflammation, tissue degeneration, and impaired...

CONCLUSION: Our findings elucidate the role of societal normative beliefs for older adults' behavior and offer insights into the discourse on the continued social participation of older adults.

Jingfang Granule (JFG), a traditional Chinese medicine preparation, is widely used in clinical practice. It has been shown to extend both lifespan and healthspan in the Caenorhabditis elegans model. However, the molecular mechanisms of its main constituents and their targets remain unclear. In this study, through network pharmacology, molecular docking, and experiments on C. elegans including lifespan assays and stress resistance assays, the bioactive compounds of JFG and their targets were...

Neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, result in a substantial health problem for the elderly, marked by ongoing neuronal degeneration and a deterioration in mental faculties. These disorders are frequently linked to oxidative stress, problems with mitochondria, and persistent inflammation in the brain, which worsen neuronal damage. The neurohormone melatonin, primarily secreted by the pineal gland, has gained recognition as a...

Geroprotectors, a class of compounds that ameliorate molecular, cellular, or physiological aging-related alterations, have garnered significant attention in the quest to promote healthy aging and extend the human health span. Among these, Calorie Restriction Mimetics (CRMs) have emerged as promising candidates due to their potential to mimic the benefits of calorie restriction, a dietary approach involving reduced calorie intake without malnutrition. Prospective CRMs may include biguanides...

Researchers used live birds to test a 50-year-old way of estimating dino speeds from fossil footprints

The grippy appendages may help engineers design robots that can navigate dense forests

Health secretary claims to be unaware of letter of protest from 300 of his agency’s scientists