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Ruling on first class action suit reversing terminations may be expanded to entire government

Trump administration is giving building to housing department but has not said where science agency will go

Study provides first solid link between climate change and earthquake hazard

New dates for a throwing weapon found in Poland reveal it as one of the earliest of its kind

Students in the life sciences are shut out of latest cohort of 500 fellows

White House battle with Ivy League school disrupts databases and networks relied on by other universities

After a judge told agency to restore hundreds of killed grants, NIH backs off plans to cancel more existing projects

The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high amyloid burden in the carrier. However, the molecular mechanisms enabling the E3S/S mutation to mitigate tau-induced neurodegeneration remain unclear. Here, we replaced mouse Apoe with wild-type human APOE3 or APOE3S/S on a tauopathy background. The R136S mutation decreased tau load and protected against tau-induced...

Neurodegenerative diseases activate innate and adaptive immune responses that can either slow or accelerate disease progression. Here, we sought to define beneficial immune pressures that emerge during tauopathy development in mice and humans. Using mice that express mutant human tau in neurons, we observed that microglia slowed tauopathy development by controlling the spread of phosphorylated tau (pTau) in the central nervous system and blood. However, over time microglia converted into...