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Age and APOE ε4 are major risk factors for Alzheimer's disease (AD), while sex differences exist in disease prevalence and progression. Cerebrospinal fluid (CSF) proteomics can provide additional insights into brain aging and AD. To examine proteomic changes due to age, sex and apolipoprotein E (APOE) ε4 along with amyloid status before clinical AD occurs, we profiled 6,175 proteins in the CSF from 994 cognitively normal individuals aged 43-91 years. We identified and replicated 2,172...

Tissue-specific endothelial cells (ECs) regulate metabolism, inflammation, coagulation, organ development and regeneration. However, therapeutic application of EC transplantation requires scalable expansion of engraftable ECs that sustain their angiogenic and angiocrine functions. Here we identify a non-canonical aryl hydrocarbon receptor (AHR) pathway switched on by canonical AHR inhibitors that reactivates quiescent EC proliferation. Incubation of tissue-specific human ECs with AHR inhibitors,...

CONCLUSIONS: Our findings underscore the need for cross-national interventions that strengthen social support, increase opportunities for social participation, improve welfare provisions, and foster social integration to mitigate the cognitive health risks posed by social isolation, thereby promoting healthy aging globally.

CONCLUSIONS: This trial showed no significant improvements in cognitive and psychological outcomes after the PICMOA intervention. However, the findings raise important considerations regarding participants' familiarity with digital devices and intervention setting. Further research is needed to accumulate evidence on the duration and intensity of intervention and individual support for improving digital literacy.

Nicotinamide adenine dinucleotide (NAD^(+)) is an essential molecule involved in cellular metabolism, and its decline has been implicated in ageing and age-related disorders. However, evidence for an age-related decline in NAD^(+) levels in humans has been consistently observed only in a limited number of studies. Similarly, although preclinical studies support the idea that supplementation with NAD^(+) precursors is a promising therapeutic strategy to promote healthy ageing, human clinical...

CONCLUSION: Our findings suggest that a higher DDS was associated with a lower risk of disability in ADL among older Chinese adults. Greater efforts to promote a diverse diet should be targeted towards older adult for preventing disability in ADL.

Birch bark tar, used as chewing gum and glue, provides rare window into life 6000 years ago

Scientists reopen the case of “splatatouille”