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Author Correction: FBP1 controls liver cancer evolution from senescent MASH hepatocytes
Ginkgolide B increases healthspan and lifespan of female mice
A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice
Author Correction: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog
I’ve been wrongly accused of bullying — what do I do?
‘There is life after burnout in academia’
The AI revolution is running out of data. What can researchers do?
How a wobbly arrow can achieve superpropulsion
US drug agency approves potent painkiller — the first non-opioid in decades
Thousands of highly cited scientists have at least one retraction
Transforming achiral semiconductors into chiral domains with exceptional circular dichroism
Science, Volume 387, Issue 6733, January 2025.
Multiplex generation and single-cell analysis of structural variants in mammalian genomes
Science, Volume 387, Issue 6733, January 2025.
Randomizing the human genome by engineering recombination between repeat elements
Science, Volume 387, Issue 6733, January 2025.
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Science, Volume 387, Issue 6733, January 2025.
Hippocampal coding of identity, sex, hierarchy, and affiliation in a social group of wild fruit bats
Science, Volume 387, Issue 6733, January 2025.
Health agencies purge Trump-targeted programs and websites
NIH spares grants so far, but ‘data apocalypse’ erupts at CDC
A new ‘mini-CRISPR’ flexes its editing power in monkey muscles
The downsized DNA-slicing machinery may reach more tissues to take aim at more diseases
Warmer, more crowded cities bring out the rats
A global study of urban rat populations explores why some urban environments are more infested than others
Public perceptions of brain health in young and middle-aged adults in Cuba: Opportunities for intervention
Understanding brain health is increasingly important, particularly in light of growing public health challenges related to neurological and psychiatric conditions. These include the rising prevalence of mental health disorders, such as depression and anxiety, as well as neurodegenerative diseases like Alzheimer's and Parkinson's. Lifestyle factors, including stress, poor diet, and insufficient physical activity, also significantly impact cognitive function. Exploring the perceptions and...
Oligodendrocyte precursor cells facilitate neuronal lysosome release
Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lysosomes. A reduction in the number or branching of OPCs reduces these contacts, which is associated with lysosome accumulation and altered metabolism in neurons and more senescent neurons with age. A...