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Daily briefing: NIH braces for reform as Trump administration closes in
Fat cells have a ‘memory’ of obesity — hinting at why it’s hard to keep weight off
Is it really a sin if it’s hardwired in? The neurological basis for ‘bad’ behaviour
Adipose tissue retains an epigenetic memory of obesity after weight loss
What a forest’s glow can reveal about the impact of environmental change
First rocks returned from Moon’s far side reveal ancient volcanic activity
Geological Net Zero and the need for disaggregated accounting for carbon sinks
Why we need a body to oversee how science is used by governments
Killer questions at science job interviews and how to ace them
Indigenous tribes engineered British Columbia’s modern hazelnut forests more than 7000 years ago
Genetic analysis of hazelnut trees could help First Nations secure land rights in Canadian courts
Octopus’ quick costume changes are costly affairs
Researchers measured for the first time how much energy it takes a ruby octopus to change all its colors at once
In search of natural riches, China plans $1 billion geoscience survey
Massive SinoProbe II project will probe the depths with drill rigs and a countrywide deployment of instruments
Amyloid-lowering treatment in Alzheimer's disease
No abstract
The catabolic - anabolic cycling hormesis model of health and resilience
A major goal of aging research is to identify ways of extending productive and disease-free lifespans. Here we present the catabolic - anabolic cycling hormesis (CACH) model for optimizing health. The CACH model is based on the concept that cells and organ systems respond to catabolic challenges in ways that bolster their resilience and that an anabolic recovery period is required to effectuate the benefits of the catabolic challenge. As two prominent real-world examples we highlight the...
Early life exercise impacts physiology and lifespan in a sex- and genotype-dependent manner in a Drosophila melanogaster exercise model
Exercise is a common strategy for disease prevention or management, including for diabetes and cardiac dysfunction. However, exercise response varies immensely between individuals, and in humans, the same exercise treatment can lead both to positive and negative responses. Drosophila melanogaster is an established model for exercise research that can be leveraged to understand this variation in exercise response. Here, we investigated how two early life exercise treatments differing in duration...
The art of aging gracefully
No abstract
Compromised CD8+ T cell immunity in the aged brain increases severity of neurotropic coronavirus infection and postinfectious cognitive impairment
Advanced age increases the risk of severe disease from SARS-CoV-2 infection, as well as incidence of long COVID and SARS-CoV-2 reinfection. We hypothesized that perturbations in the aged antiviral CD8^(+) T cell response predisposes elderly individuals to severe coronavirus infection, re-infection, and postinfectious cognitive sequelae. Using MHV-A59 as a murine model of respiratory coronavirus, we found that aging increased CNS infection and lethality to MHV infection. This was coupled with...
Passive anti-amyloid beta immunotherapy in Alzheimer's disease-opportunities and challenges
With the advent of the first disease-modifying, anti-amyloid β-directed passive immunotherapy for Alzheimer's disease, questions arise who, when, and how to treat. This paper describes shortly the pathogenic basis of and preclinical data, which have, more than two decades ago, initiated the development of this vaccination therapy. We discuss clinical trial results of aducanumab, lecanemab, and donanemab. We also review appropriate use recommendations of these novel treatments on patient...
Comparison of the efficacy of updated drugs for the treatment on the improvement of cognitive function in patients with Alzheimer 's disease: A systematic review and network meta- analysis
CONCLUSION: Donanemab and Lecanemab showed good efficacy in ADCS-ADL and CDR-SB, respectively. GV-971 is the best choice to improve ADAS cogs and NPI.
Combined graph convolutional networks with a multi-connection pattern to identify tremor-dominant Parkinson's disease and Essential tremor with resting tremor
Essential tremor with resting tremor (rET) and tremor-dominant Parkinson's disease (tPD) share many similar clinical symptoms, leading to frequent misdiagnoses. Functional connectivity (FC) matrix analysis derived from resting-state functional MRI (Rs-fMRI) offers a promising approach for early diagnosis and for exploring FC network pathogenesis in rET and tPD. However, methods relying solely on a single connection pattern may overlook the complementary roles of different connectivity patterns,...