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Order-to-disorder transition due to entropy in layered and 2D carbides

5 months ago
Science, Volume 389, Issue 6764, Page 1054-1058, September 2025.
Brian C. Wyatt, Yinan Yang, Paweł P. Michałowski, Tetiana Parker, Yamilée Morency, Francesca Urban, Givi Kadagishvili, Manushree Tanwar, Sixbert P. Muhoza, Srinivasa Kartik Nemani, Annabelle Bedford, Hui Fang, Zachary D. Hood, Junwoo Jang, Krutarth…

Evolution of thumbnails across Rodentia

5 months ago
Science, Volume 389, Issue 6764, Page 1049-1053, September 2025.
Rafaela V. Missagia, Anderson Feijó, Lauren Johnson, Maximilian L. Allen, Bruce D. Patterson, Paulina D. Jenkins, Gordon M. G. Shepherd

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease

5 months ago
Neuroinflammation drives Alzheimer's disease (AD) pathogenesis. Z-DNA, a non-canonical left-handed DNA structure, activates innate immune signaling through Z-DNA-binding protein 1 (ZBP1). However, the functional significance of ZBP1-mediated Z-DNA detection in AD remains undefined. Here, we found that ZBP1 is amplified in AD microglia, driving innate immune responses and neuroinflammation through sensing Z-form mitochondrial DNA (mtDNA). We show that oxidized mtDNA, generated by amyloid-β...
Ziwen Song