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Daily briefing: A ‘data apocalypse’ at US public-health agencies
Exclusive: how NSF is scouring research grants for violations of Trump’s orders
How COVID vaccination keeps a ‘breakthrough’ infection in check
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Left–right-alternating theta sweeps in entorhinal–hippocampal maps of space
Omega-3 supplements slow biological ageing
I spent a year studying campus sexual violence. Here’s what I found out
Microbes in space: how bacteria could help sustain long-distance space travel
NASA’s ‘most prolific planet hunter so far’ — the story of the Kepler Space Telescope
Why even physicists still don’t understand quantum theory 100 years on
Researching endangered animals in the Sahara has its own dangers
Author Correction: Joint speech and text machine translation for up to 100 languages
Publisher Correction: Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia
Tally of bones, artifacts reveals 2000 years of population swings among Indigenous Americans
Tens of thousands of radiocarbon dates track different regions’ population history before European arrival
U.S. foreign aid freeze derails efforts to stem proliferation risks
Trump order could leave United States blind to foreign efforts to turn lab discoveries into weapons of mass destruction
Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging
Age-related differences in fluid cognition have been associated with both the merging of functional brain networks, defined from resting-state functional magnetic resonance imaging (rsfMRI), and with elevated cortical iron, assessed by quantitative susceptibility mapping (QSM). Limited information is available, however, regarding the depthwise profile of cortical iron and its potential relation to functional connectivity. Here, using an adult lifespan sample (n = 138; 18-80 years), we assessed...
Mothers with obesity and gestational diabetes did not induce brain pathologies or premature brain aging in their adolescent and early adult offspring in rats
This study investigated the effect of a medium high-fat diet (HFD)-induced maternal obesity and gestational diabetes mellitus (GDM) on rat offspring to verify the hypothesis that maternal obesity and GDM cause brain pathologies and premature brain aging in the prefrontal cortex and hippocampus of the adolescent and early adult offspring. Maternal obesity and GDM were generated by a medium HFD and HFD combined with streptozotocin, respectively. Metabolic parameters were used to confirm the...
Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence
The onset of multiple sclerosis (MS) in older individuals correlates with a higher risk of developing primary progressive MS, faster progression to secondary progressive MS, and increased disability accumulation. This phenomenon can be related to age-related changes in the immune system: with age, the immune system undergoes a process called immunosenescence, characterized by a decline in the function of both the innate and adaptive immune responses. This decline can lead to a decreased ability...
A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice
Structural and functional changes in the entorhinal cortex (EC) are among the earliest signs of cognitive aging. Here, we ask whether a compromised cholinergic system influences early EC impairments and plays a primary role in EC cognition. We evaluated the relationship between loss of integrity of cholinergic inputs to the EC and cognitive deficits in otherwise healthy humans and mice. Using in vivo imaging (PET/MRI) in older humans and high-resolution imaging in wild-type mice and mice with...
Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction
Polymorphisms in CD2-associated protein (CD2AP) predispose to Alzheimer's disease (AD), but the underlying mechanisms remain unknown. Here, we show that loss of CD2AP in cerebral blood vessels is associated with cognitive decline in AD subjects and that genetic downregulation of CD2AP in brain vascular endothelial cells impairs memory function in male mice. Animals with reduced brain endothelial CD2AP display altered blood flow regulation at rest and during neurovascular coupling, defects in...