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Microbiological Foundations to Optimise Intrinsic Capacity and Promote Healthy Ageing: An Integration Into the Life Course Approach
The World Health Organization (WHO) defines healthy ageing as the process of developing and maintaining functional ability, comprising an individual's intrinsic capacity, the environment and the interaction of the two. The framework is based on a positive approach to ageing, giving value to the resources individuals can rely upon as they age and that they can build their physical, mental and social health, and overall well-being. To promote healthy ageing, it is important to understand better...
China’s massive coastal restoration project could backfire
Study finds that efforts to replace an invasive weed could spike greenhouse gas emissions in the region
Trump cuts subscriptions to Springer Nature journals
Other publishers appear unscathed in recent actions
Daily briefing: The oldest rocks on Earth
Arrests of scientists over smuggled samples add to US border anxiety
Exclusive: NIH still screens grants in process a judge ruled illegal
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy
Age-dependent accumulation of mitochondrial tRNA mutations in mouse kidneys linked to mitochondrial kidney diseases
Niède Guidon obituary: Brazilian archaeologist who upended ideas on early human migration
First independent survey of deaths in Gaza reports more than 80,000 fatalities
Can AI build a virtual cell? Scientists race to model life’s smallest unit
WHO panel favors natural origin of COVID-19 virus but decries missing evidence
New report doesn’t rule out that SARS-CoV-2 leaked from a lab in China, but says evidence for scenario remains “speculation”
Social media attacks on public health agencies are eroding trust
Attacks on an institution’s integrity spur more anger—and engagement—than other types of criticisms, study suggests
UV-C light kills nearly everything—except this unusual organism
Built-in Sun protection might be a blueprint for surviving in space
NIH will reinstate 900 grants in response to court order
Projects touching on sensitive topics such as DEI had been illegally terminated, judge found
A trial of fetal cells for Parkinson's disease brings lessons for the field
No abstract
A lysosomal surveillance response to stress extends healthspan
Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal that silencing specific vacuolar H^(+)-ATPase subunits (for example, vha-6), which are essential for intestinal lumen acidification in Caenorhabditis elegans, extends lifespan by ~60%. This longevity phenotype can be explained by an adaptive...
Reliability and validity of the Clinical pHysical rEsilience assEssment Scale (CHEES) in community-dwelling older adults
CONCLUSIONS: The CHEES exhibits good reliability and validity; therefore, it can be used as a reliable tool for evaluating the physical resilience of older adults in community settings.
Can a pill replace exercise? Swigging this molecule gives mice benefits of working out
No abstract
A host organelle integrates stolen chloroplasts for animal photosynthesis
Eukaryotic life evolved over a billion years ago when ancient cells engulfed and integrated prokaryotes to become modern mitochondria and chloroplasts. Sacoglossan "solar-powered" sea slugs possess the ability to acquire organelles within a single lifetime by selectively retaining consumed chloroplasts that remain photosynthetically active for nearly a year. The mechanism for this "animal photosynthesis" remains unknown. Here, we discovered that foreign chloroplasts are housed within novel,...