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Beyond their classical roles in hemostasis and coagulation, accumulating evidence highlights platelets as multifaceted regulators within the nervous system. Research has revealed that platelet-derived factors promote blood-brain barrier (BBB) maturation and angiogenesis via neurochemical pathways. At the same time, platelet-rich plasma (PRP) facilitates neural regeneration by mitigating the neurotoxicity of amyloid-beta (Aβ) and activating the PI3k/Akt signaling pathway. Platelets also modulate...

Normal aging is associated with decline in dopamine function. Factors associated with individual differences in dopamine decline rates remain unclear but are important to map to spare dopamine-related functions, such as cognition. Here we focused on manifestations of cerebral small-vessel disease from magnetic resonance imaging (white-matter lesions, lacunes, and perivascular space dilation) and vascular risk factors (e.g., hypertension, body mass index (BMI), and hyperlipidemia). We assessed...

Sarcopenia is characterized by aging-related progressive loss of muscle mass and function; however, the specific and sensitive biomarkers are still limited. Biometals and trace elements provide a potential connection linking the environment and lifestyle to pathological processes of sarcopenia. The aim of the present study was to investigate the relationship between urinary trace elements levels and the presence of sarcopenia. A total of 100 older adults aged ≥65 years consisting of 50 patients...

CONCLUSION: ABLE demonstrated the feasibility of recruiting biologically older yet generally healthy middle-aged adults for gerotherapeutic interventions.

Mitochondrial dysfunction and accumulation of α-synuclein aggregates are hallmarks of the neurodegenerative Parkinson's disease and may be interconnected. To investigate the interplay between α-synuclein and brain mitochondria at near atomic structural level, we apply NMR and identify α-synuclein protein interactors using limited proteolysis-coupled mass spectrometry (LiP-MS). Several of the proteins identified are related to ATP synthesis and homeostasis and include subunits of ATP synthase and...

Parkinson's Disease (PD) is a progressive neurodegenerative disorder marked by motor impairments such as tremors, rigidity, and bradykinesia. Regular physical activity plays a key role in managing these symptoms, yet the COVID-19 pandemic imposed social isolation measures that significantly curtailed physical activity, potentially accelerating motor decline. This systematic review aimed to synthesize evidence on the impact of pandemic-related social isolation on motor symptom deterioration in...

CONCLUSION: It was determined that nurses' views on old age and aging affect their attitudes towards the older patients. It was observed that nurses' views on old age and aging were negative, but their attitudes towards the older patients were positive.

Hair loss affects millions globally, significantly impacting quality of life and psychological well-being. Despite its prevalence, effective strategies for promoting human hair growth remain elusive. By investigating congenital generalized hypertrichosis terminalis (CGHT), a rare genetic disorder characterized by excessive hair growth, we discover that chromatin deletions or an inverted duplication disrupt the topologically associating domain (TAD), leading to the upregulation of the potassium...

Muscle volume, strength, physical performance, and quality (functional and morphological domains) decline with age; however, the specific patterns and differences among these variables in old age remain unclear. We quantitatively assessed sex- and age-related changes and differences among these variables in older adults. We hypothesized that the rates of age-related decline differ among the parameters. Specifically, muscle quality would decline more steeply than muscle mass, with sex-related...

Diversity in biological, social, and environmental factors plays a central role in shaping brain health and disease. Distinct brain disorders frequently exhibit overlapping clinical phenotypes, despite arising from heterogeneous biological and contextual mechanisms. This convergence challenges conventional, population-averaged approaches, which often fail to capture interindividual variability and lead to limited reproducibility, weak translational potential, and inadequate tools for...

CONCLUSIONS: The results present the complex connection between cardiometabolic disorders, their treatment and cognitive functioning. The research highlights the necessity for a tailored approach in prescribing cardiovascular medications, considering their potential link with cognitive health. Especially the role of angiotensin II receptor antagonists merits further studies.

CONCLUSIONS: The study found that BMR is positively associated with cognitive function, whereas sarcopenia is inversely associated with cognitive function and mediates the BMR- cognitive function association.

CONCLUSION: ST in prolonged bouts was associated with higher cardiometabolic risk severity, whereas ST in short bouts was linked to lower risk in community-dwelling older adults.

DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein), which is a major macroautophagy/autophagy-repressive protein, is emerging as a key player in hepatocellular carcinoma (HCC) pathogenesis through multifaceted roles that encompass both cell-intrinsic and -extrinsic mechanisms. Beyond promoting cancer cell proliferation, DBI/ACBP contributes to a pro-tumorigenic microenvironment by sustaining inflammation and impairing immunosurveillance. Experimental models of HCC, whether induced...

CONCLUSIONS: In this nationally representative sample of Chinese older adults, VI, HI, and DSI, were significantly associated with an increased risk of cognitive impairment. Future studies are encouraged to employ standardized tools to assess sensory and cognitive impairments, further explore the mechanisms linking the two, and consider the potential benefits of incorporating sensory impairment assessment and management into primary healthcare to reduce the risk of cognitive impairment.

Cortisol has been widely used as biomarker of stress and aging, but confounding effects and disruption of the hypothalamic-pituitary-adrenal axis can lead to misinterpretation of results based on a single measurement. A possible alternative is the co-measurement of cortisol and the adrenal hormone dehydroepiandrosterone-sulfate (DHEAS), a glucocorticoid antagonist that modulates the stress response. Using data from 969 individuals from the Midlife in the United States study, this study aimed to...

Cognitive impairment and dementia in older adults represent significant global health challenges. Although the bidirectional relationship between physical function and brain health is well established, the mechanistic drivers of this link remain poorly understood. Muscle function and quality are central to physical function, and muscle's secretome is increasingly recognized for its systemic health effects-supporting the potential for muscle-to-brain crosstalk. This concept was explored at the...

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Neurodegeneration is a hallmark of various neurological disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), stroke, and neurotropic viral infections. Although the precise etiology remains unclear, multiple pathological mechanisms contribute to disease progression, including mitochondrial dysfunction, protein aggregation, calcium excitotoxicity, endoplasmic reticulum (ER) stress, oxidative stress, immune system activation, and neuroinflammation. Among these, the immune...