Aggregator
How quickly are you ageing? What molecular 'clocks' can tell you about your health
No abstract
Protective role of parenthood on age-related brain function in mid- to late-life
The experience of human parenthood is near ubiquitous and can profoundly alter one's body, mind, and environment. However, we know very little about the long-term neural effects of parenthood for parents themselves, or the implications of pregnancy and caregiving experience on the aging adult brain. Here, we investigate the link between the number of children parented and age on brain function in 19,964 females and 17,607 males from the UK Biobank. In both females and males, parenthood was...
SenSkin: a human skin-specific cellular senescence gene set
Cellular senescence gene sets have been leveraged to overcome the inadequate sensitivity or specificity of single markers. However, growing evidence of heterogeneity among tissues in senescent cell phenotypes and gene expression profiles has highlighted the need for tissue-specific gene sets. SenSkin™ was curated by an expert review of literature on cellular senescence in the skin and characterized with pathway analysis. To validate SenSkin™, it was evaluated for enrichment with chronological...
Daily briefing: Postdocs and PhD students hit hard by Trump’s crackdown on science
Trump 2.0: an assault on science anywhere is an assault on science everywhere
My experience of speaking at a conference with a baby
How to develop a good writing style
Author Correction: A comprehensive spatio-cellular map of the human hypothalamus
Author Correction: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours
PhD scientists who forged a career off the beaten track
How quickly are you ageing? What molecular ‘clocks’ can tell you about your health
Move beyond ‘publish or perish’ by measuring behaviours that benefit academia
We use 30 billion tonnes of concrete each year — here’s how to make it sustainable
China’s low-altitude economy needs to grow with more caution
National climate policies must address mental health
Other countries should copy Nepal’s approach to tackling cervical cancer
Sharing benefits of research is key to effective science communication
Fusion scientist named chief of the U.K.’s national funding agency
Ian Chapman to oversee UK Research and Innovation, which has an annual budget of £9 billion
GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles
Pronounced elevation of glycoprotein non-metastatic melanoma B (GPNMB) is a common phenomenon in a variety of brain diseases, but the expression patterns, functions, and molecular signaling of GPNMB have not been well studied. Here, we showed that pathological factors, including neuronal degeneration caused by seizures, caspase-3-induced neuronal apoptosis, neuronal debris, and β-amyloid, induced "on-demand" GPNMB expression in hippocampal microglia. Genetic ablation of GPNMB did not affect...
Deep learning to quantify the pace of brain aging in relation to neurocognitive changes
Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since birth. Thus, it conveys poorly recent or contemporaneous aging trends, which can be better quantified by the (temporal) pace P of brain aging. Many approaches to map P, however, rely on quantifying DNA methylation in whole-blood cells, which the...