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Longevity of cardiac and skeletal muscle proteins is dependent on tissue and subcellular compartmentation patterns

4 months ago
Myocytes are exceptionally long-lived cells that must maintain proteome integrity over decades while adjusting for changes in functional output and metabolic demand. We used in vivo stable isotope labeling combined with mass spectrometry proteomics and correlated multi-isotope imaging mass spectrometry to quantify and visualize protein turnover across cardiac, fast-twitch, and slow-twitch skeletal muscles, creating a resource of hundreds of individual protein turnover rates from each tissue. We...
Jack Gugel

Immunosuppressive macrophages determine the effect of cellular senescence on tumor progression

4 months ago
Cells terminally arrested in the cell cycle that exhibit a distinct secretory phenotype are referred to as senescent. These cells play a complex role during tumor progression; they can inhibit or promote tumor growth depending on disease stage. We developed a mouse model that allows monitoring and selective elimination of cells expressing high levels of the cyclin-dependent kinase inhibitor p16 and interleukin-6. These mice, termed SuSe (suicidal senescence), were crossed with the mouse mammary...
Marta Lalinde-Gutiérrez

In Science Journals

4 months ago
Science, Volume 391, Issue 6780, Page 42-44, January 2026.
Michael Funk, and Henk A. Dijkstra, Yury Suleymanov, Jelena Stajic, Jake S. Yeston, Madeleine Seale, Mark Aldenderfer, Wei Wong, Phil Szuromi, Mattia Maroso, Caroline Ash, Michael A Funk, Sacha Vignieri, Corinne Simonti, Yevgeniya Nusinovich, Keith T…