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Pierre Poilievre’s Conservative Party is trying to topple Liberal government in 28 April election

Amid negotiations with Trump, the university could risk losing nearly $700 million

Move could open the door to using high-profile report to attack climate science

Reduced histone acetylation in the brain causes transcriptional dysregulation and cognitive impairment that are key initial steps in Alzheimer's disease (AD) etiology. Unfortunately, current treatment strategies primarily focus on histone deacetylase inhibition (HDACi) that causes detrimental side effects due to non-specific acetylation. Here, we test Tip60 histone acetyltransferase (HAT) activation as a therapeutic strategy for selectively restoring cognition-associated histone acetylation...

Aging is associated with a progressive decline in circulating insulin-like growth factor- 1 (IGF- 1) levels in humans, which has been implicated in the pathogenesis of sarcopenia. IGF- 1 is an anabolic hormone that plays a dual role in maintaining skeletal muscle health, acting both directly on muscle fibers to promote growth and indirectly by supporting the vascular network that sustains muscle perfusion. However, the microvascular consequences of IGF- 1 deficiency in aging muscle remain poorly...

With aging, the hippocampal formation shows variable structural atrophy, which is associated with a decline in cognitive performance. Bilingualism is related to higher hippocampal gray matter volume (GMV), potentially representing a form of brain reserve in aging. However, the differential influence of bilingualism on hippocampal subregions remains unclear. Thus, we investigated GMV differences and differences in age-GMV relationships between mono- and bilinguals in the hippocampal formation and...

Longevity research aims to extend the healthspan while minimizing the duration of disability and morbidity, known as the sickspan. Most longevity interventions in model organisms extend healthspan, but it is not known whether they compress sickspan relative to the lifespan. Here, we present a theory that predicts which interventions compress relative sickspan, based on the shape of the survival curve. Interventions such as caloric restriction that extend mean lifespan while preserving the shape...

No abstract

CONCLUSIONS: The influence of protein on muscle mass was not significantly efficacious, and mixed results were shown for muscle strength and physical performance. Further well-designed studies are needed to determine the effectiveness of protein supplementation to maximize its potential benefits in older individuals with physical inactivity.

CONCLUSIONS: CGA provides rationale for oral health problem analysis, treatment planning, and oral healthcare. The expert opinions underscore the importance of comprehensive and individualized care plans suggested in the oral treatment plan model. The multiple dimensions of CGAs include systemic and oral health, socioeconomic factors, dependency, cognitive and mental health, swallowing problem, nutrition, and fall risk. The selection of assessment tools should be optimized based on the purposes...

CONCLUSION: High serum 25(OH)D levels and vigorous recreational activity have been linked to a reduced risk of oral care need among older adults. 25(OH)D is a potential mediator of the reduced need for oral health care associated with vigorous recreational activity when combined effects are considered. Vitamin D supplementation and increased physical activity may be a potential cost-effective oral public health strategy for older adults.

Impaired neuronal and synaptic function are hallmarks of early Alzheimer's disease (AD), preceding other neuropathological traits and cognitive decline. We previously showed that SFRP1, a glial-derived protein elevated in AD brains from preclinical stages, contributes to disease progression, implicating glial factors in early pathogenesis. Here, we generate and analyze transgenic mice overexpressing astrocytic SFRP1. SFRP1 accumulation causes early dendritic and synaptic defects in adult mice,...

Clonal dominance characterizes hematopoiesis during aging and increases susceptibility to blood cancers and common nonmalignant disorders. VEXAS syndrome is a recently discovered, adult-onset, autoinflammatory disease burdened by a high mortality rate and caused by dominant hematopoietic clones bearing somatic mutations in the UBA1 gene. However, pathogenic mechanisms driving clonal dominance are unknown. Moreover, the lack of disease models hampers the development of disease-modifying...

No abstract

Circular RNAs (circRNAs) are non-coding RNAs mostly derived from exons of protein-coding genes via a back-splicing process. The expression of hundreds of circRNAs accumulates during healthy aging and is associated with Alzheimer's disease (AD), which is characterized by the accumulation of amyloid-beta (Aβ) proteins. In C. elegans, many circRNAs were previously found to accumulate during aging, with loss of age-accumulated circRNAs derived from the CREB gene (circ-crh-1) to increase mean...

CONCLUSION: Olfactory decline is related to both increased cerebrovascular burden and accelerated brain atrophy over time.

CONCLUSIONS: Community-living older Americans who reside in disadvantaged counties have a higher incidence of frailty, probable dementia, and ADL disability over a 5-year follow-up period compared to their non-disadvantaged counterparts. Findings underscore the vital, underappreciated role that county-level social contextual disadvantage plays on clinically meaningful outcomes in older persons in the U.S.

“Landmark” study fingers fire-footed rope squirrel as a reservoir of fatal disease