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‘Wind droughts’ driven by climate change put green power at risk
Daily briefing: Ageing accelerates after 50 — but not all organs age at the same rate
China reins in the spiralling construction costs of nuclear power — what can other countries learn?
Artificial diamonds are forever: 70 years of synthesizing these iconic gems
‘For AI to change how economies work, it has to represent all of us’
Why space foods aren’t just for space
Physicists unleashed the power of the atom — but to what end?
How I’m helping to develop more-resilient food systems
Dietary patterns and accelerated multimorbidity in older adults
Hard paths: how courage differs from bravery in science
Postdocs get more equipment time when applications are anonymized
Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
Genomewide study makes ‘quantum leap’ in understanding stuttering
Analysis of DNA from 23andMe users points to variants in genes linked to brain function and sense of rhythm
NSF plans abrupt end to lone U.S. Antarctic research icebreaker
Imminent termination of the RV Nathaniel B. Palmer shocks polar scientists
Peacock feathers can be lasers
Tail feathers can emit narrow beams of light, a first in the animal kingdom
Alterations in mitochondria and cellular senescence in aged sEH null female kidneys
Age-related structural and functional deterioration of the kidneys is common among elderly individuals and contributes to increased mortality and morbidity. Mitochondrial dysfunction and cellular senescence are two hallmarks of aging that drive a progressional renal decline; however, the underlying molecular mechanisms and endogenous regulators behind these processes remain incompletely understood. The metabolism of polyunsaturated fatty acids by CYP450 enzymes produces numerous bioactive lipid...
Single-Cell Sequencing Reveals That CD4(+) T Cells Eliminate Senescent Prostate Epithelium to Delay Progression of Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) is an age-related condition characterized by progressive prostate enlargement driven in part by the accumulation of senescent epithelial cells and their pro-inflammatory secretome. Using human single-cell RNA sequencing and laser capture microdissection, we identified C-X-C Motif Chemokine Ligand 13 (CXCL13) as a key chemokine secreted by senescent prostate epithelial cells. CXCL13 recruits CD4^(+) T cells via the C-X-C Chemokine Receptor Type 5 (CXCR5)...
The Effect of Aging at Moderate Altitude on Cognition and Symptoms of Depression and Anxiety
Background Minor and major neurocognitive disorders, depression, and anxiety are common in older adults. The brain and specifically the aging brain, relies heavily on oxygen and is highly sensitive to reductions in oxygen availability. Hypoxia occurs during both acute and prolonged exposure to altitude. While the negative effects of very low oxygen levels at high altitudes (above 3500 m) on cognition and symptoms of depression as well as anxiety are well-documented, we propose that moderate...
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation
Germline genetic architecture of Alzheimer's disease (AD) indicates microglial mechanisms of disease susceptibility and outcomes. However, the mechanisms enabling protective microglial responses remain elusive. Here, we investigate the role of microglial ADGRG1, an adhesion G-protein-coupled receptor (aGPCR) specifically expressed in yolk-sac-derived microglia, in AD pathology using the 5xFAD mouse model. Transcriptomic analyses reveal that ADGRG1 activates the transcription factor MYC, leading...
AAV9-mediated transduction of memory circuits following convection-enhanced delivery into the olfactory bulbs
This study explores the potential of adeno-associated virus serotype 9 (AAV9) to deliver therapeutic genes directly into the memory circuit throughout the olfactory bulb (OB), a critical memory and sensory processing region. Using convection-enhanced delivery (CED) of AAV9 encoding green fluorescent protein (GFP), we mapped the extensive neural connectivity from the OB to key memory-related brain regions, including the entorhinal cortex (EC) and hippocampus. Our findings reveal significant...