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Enhanced focality and intensity in deep brain targeting: In silico study on multi-channel temporal interference stimulation for Parkinson's disease

3 months 4 weeks ago
This study introduces a novel multi-channel temporal interference stimulation (M-TIS) paradigm and rigorously evaluates its capacity to non-invasively target the globus pallidus internus (GPi), a pivotal region in Parkinson's disease (PD) treatment. Employing realistic human head models derived from MRI data and sophisticated finite element modeling, we demonstrate that M-TIS achieves significantly enhanced stimulation intensity and focality within the GPi compared to conventional single-channel...
Bangyu Wang

Smoking Promotes AT2 Cell Senescence and Exacerbates Pulmonary Fibrosis by Downregulating POT1 via Integratively Inducing CpG Methylation and MECP2-Mediated FOXP2 Transcriptional Binding Inhibition

3 months 4 weeks ago
Smoking is one of the most recognized risk factors for pulmonary fibrosis (PF). However, the underlying mechanism is not well understood. This study reveals smoking increases the risk of developing idiopathic PF (IPF) and that smoked IPF patients exhibit higher levels of senescence markers than non-smoker IPF patients. Moreover, smoking enhances bleomycin (Bleo)-induced PF, along with obvious senescence of type II alveolar (AT2) cells. RNA-seq assay identifies cigarette downregulates protection...
Mengkun Shi