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G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
Science, Volume 387, Issue 6738, March 2025.
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Science, Volume 387, Issue 6738, March 2025.
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
Science, Volume 387, Issue 6738, March 2025.
Tropical forests in the Americas are changing too slowly to track climate change
Science, Volume 387, Issue 6738, March 2025.
NIH will eliminate many peer-review panels and lay off some scientists overseeing them
Friday Trump Tracker: science rallies, last-minute job extensions, food safety panels killed
Follow President Donald Trump’s impact on U.S. research and science globally
RFK Jr. says federal vaccine advisers are beholden to industry. The evidence does not support him
A Science investigation finds no sign that members of a key CDC vaccine committee are compromised
Thousands gather across U.S. and world in Stand Up for Science events
Scientists and their supporters rallied across the country in response to layoffs and funding cuts ordered by the Trump administration
Panels giving scientific advice to Census Bureau disbanded by Trump administration
New commerce secretary tells advisers to federal statistical agencies that their mission has been “fulfilled”
USDA ordered to reinstate nearly 6000 fired workers
Temporary ruling brings relief, but could be followed by a new wave of firings
Hippocampal neural stem cell exosomes promote brain resilience against the impact of tau oligomers
A promising therapeutic intervention for preventing the onset and progression of Alzheimer's Disease (AD) is to protect and improve synaptic resilience, a well-established early vulnerability associated with the toxic effects of oligomers of Aβ (AβO) and Tau (TauO). We have previously reported that exosomes from hippocampal neural stem cells (NSCs) protect synapses against AβO. Here, we demonstrate how exosomes can also shield against TauO toxicity in adult mice synapses, potentially benefiting...
Retraction: Larson et al., "Soluble alpha-Synuclein is a Novel Modulator of Alzheimer's Disease Pathophysiology"
No abstract
Retraction: Larson et al., "The Complex PrP(c)-Fyn Couples Human Oligomeric Abeta with Pathological Tau Changes in Alzheimer's Disease"
No abstract
New mechanisms highlight the complex relationship of Apolipoprotein E and tau pathogenesis
A rare variant of Apolipoprotein E3 with neuroprotective properties has been identified in autosomal-dominant Alzheimer's disease. In this issue of Neuron, Chen et al.¹ show that direct interaction between this variant and tau blocks tau pathogenesis in rodent models.
Microglial mechanisms drive amyloid-beta clearance in immunized patients with Alzheimer's disease
Alzheimer's disease (AD) therapies utilizing amyloid-β (Aβ) immunization have shown potential in clinical trials. Yet, the mechanisms driving Aβ clearance in the immunized AD brain remain unclear. Here, we use spatial transcriptomics to explore the effects of both active and passive Aβ immunization in the AD brain. We compare actively immunized patients with AD with nonimmunized patients with AD and neurologically healthy controls, identifying distinct microglial states associated with Aβ...
Mechanistic insights into EIF6 as a target of Apigenin in alleviating chondrocyte senescence
CONCLUSION: Apigenin upregulates EIF6 expression and mitigates H2O2-induced chondrocyte senescence, highlighting its potential as a therapeutic agent for KOA. These findings provide insights into the nutritional health benefits of Apigenin and its implications for KOA treatment.
Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow
The aging of hematopoietic stem cells (HSCs) substantially alters their characteristics. Mitochondria, essential for cellular metabolism, play a crucial role, and their dysfunction is a hallmark of aging-induced changes. The impact of mitochondrial mass on aged HSCs remains incompletely understood. Here we demonstrate that HSCs with high mitochondrial mass during aging are not merely cells that have accumulated damaged mitochondria and become exhausted. In addition, these HSCs retain a high...
Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAge
Epigenetic aging clocks represent contemporary aging biomarkers that predict age using methylomic data. These models can be categorized as first-generation clocks that estimate chronological age or next-generation clocks that are designed to associate with health, lifestyle, and/or outcomes. Recently, we created a next-generation buccal clock called CheekAge that associates with all-cause mortality risk in older adults. To better understand our model, we collated 25 Infinium MethylationEPIC...
Construction and validation of a DNN-based biological age and its influencing factors in the China Kadoorie Biobank
Biological age is an important measure of aging that reflects an individual's physical health and is linked to various diseases. Current prediction models are still limited in precision, and the risk factors for accelerated aging remain underexplored. Therefore, we aimed to develop a precise biological age and assess the impact of socio-demographic and behavioral patterns on the aging process.We utilized Deep Neural Networks (DNN) to construct biological age from participants with physical...
Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species
Ageing is associated with a range of chronic diseases and has diverse hallmarks. Mitochondrial dysfunction is implicated in ageing, and mouse-models with artificially enhanced mitochondrial DNA mutation rates show accelerated ageing. A scarcely studied aspect of ageing, because it is invisible in aggregate analyses, is the accumulation of somatic mitochondrial DNA mutations which are unique to single cells (cryptic mutations). We find evidence of cryptic mitochondrial DNA mutations from diverse...