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Searching for a Potential Blue Zone in the Nordics: A Study on Differences in Lifestyle and Health in Regions Varying in Longevity in Western Finland
To delay social and healthcare utilisation among the ageing population, there is an increasing focus on the role of health-promoting lifestyle adopted at an individual and/or community level. Longevity is generally viewed as the ultimate outcome of health, although a high life expectancy does not necessarily go together with health and/or a health-promoting lifestyle. The potential coherence between longevity, health and lifestyle may vary in different cultural, political, social and economic...
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans. These transcription factors coordinate nutrient sensing with carbohydrate and lipid metabolism across the evolutionary spectrum. While most studies have focused on the downstream outputs, little is known about the upstream inputs that regulate these transcription factors in a live organism. Here, we found that knockdown of...
Associations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20-93: The INSPIRE-T Project
Evidence connecting skin aging to functional decline and systemic aging biomarkers is lacking. This study investigated how skin-aging biomechanics were associated with changes in intrinsic capacity (IC), a marker of healthy aging. We also explored their links with biological aging clocks (epigenetic and inflammatory clocks) and potential moderating effects on the skin-IC relationship. Baseline skin elasticity and viscoelasticity were measured in 441 INSPIRE-T participants aged 20 to 93 (59.9%...
Daily briefing: Political officials could control US federal science grants
How Indigenous values permeate my chemistry teaching and research
Six questions to ask before jumping into a spreadsheet
How does agricultural land become forest? I trek to find out
Catalytic enantioselective synthesis of alkylidenecyclopropanes
Author Correction: A virtual rodent predicts the structure of neural activity across behaviours
Author Correction: RNA codon expansion via programmable pseudouridine editing and decoding
Death threats to NIH official spark debate over aggressive campaign to end animal research
White Coat Waste Project files complaint over government employee’s emails claiming it incited harassment against Nicole Kleinstreuer
New method reveals perhaps the most massive black hole yet spotted
Big brute 5 billion light-years from Earth is 36 billion times as massive as the Sun
NIH ponders overhauling HIV budget to capitalize on prevention breakthrough
Scientists warn $1 billion push for “implementation science” spurred by promise of lenacapavir will hurt research on new treatments and vaccines
The role of hemoglobin/red cell distribution width value in predicting early major adverse events after open heart surgery in elderly patients
CONCLUSION: In this study, we showed for the first time in the literature that the HRR value calculated from preoperative blood values is a key predictor for in-hospital MAE. In these patients, the HRR value can be used as a preoperative risk biomarker.
Analysis of variability and epigenetic age prediction across microarray and methylation sequencing technologies
Using 100 technical replicate samples from two adult buccal cohorts, we compared technical methylation variability and signal strength between the Infinium MethylationEPIC v2.0 array and the Twist Human Methylome Panel across 753,648 shared CpGs. Twist methylation sequencing showed skewed methylation distributions and fewer highly correlated CpGs than MethylationEPIC arrays. Variance analysis revealed a skew toward higher signal strength in MethylationEPIC datasets, with a subset of CpGs showing...
Efficacy of progressive resistance training intensities and adequate dietary protein intake for community-dwelling frail older adults (TEAMS study), protocol for a randomised controlled trial
BACKGROUND: Progressive Resistance Training (PRT) and adequate dietary protein are crucial for preventing and managing sarcopenia and frailty in older adults. To date, the optimal intensity of PRT and the added value of dietary protein for enhancing muscle mass, strength, and physical performance in frail older adults remain unclear. This randomised controlled trial aims to determine the efficacy of various PRT intensities and adequate dietary protein intake in improving muscle mass, strength...
Advancements in the investigation of the mechanisms underlying cognitive aging
Cognitive aging, a pivotal domain at the intersection of neuroscience and psychology, exhibits a strong association with neurodegenerative disorders; however, its comprehensive underlying mechanisms remain incompletely elucidated. This review aims to provide a thorough synthesis of recent advancements in the investigation of cognitive aging in the brain, highlighting multidimensional assessment techniques, neurobiological foundations, molecular regulatory pathways, systemic changes,...
Pathogens accelerate features of human aging: A review of molecular mechanisms
Many models of aging assume that processes such as cellular senescence or epigenetic alteration occur under sterile conditions. However, humans sustain infection with viral, bacterial, fungal, and parasite pathogens across the course of a lifetime, many of which are capable of long-term persistence in host tissue and nerves. These pathogens-especially members of the human virome like herpesviruses, as well as intracellular bacteria and parasites-express proteins and metabolites capable of...
A unique subpopulation of wild-type neurons recapitulating familial Alzheimer's disease phenotypes
Mutations in the genes encoding APP, Presenilin-1 (PSEN1), and PSEN2 result in early-onset Alzheimer's disease (AD). Previous studies, using iPSC-derived neurons and/or knock-in mice, elucidated the characteristics of neurons expressing familial AD (fAD) mutations. Here, we employ biochemical and state-of-the-art fluorescence imaging assays and report the discovery of a unique subpopulation of wild-type neurons strikingly recapitulating key phenotypes previously identified in the fAD neurons,...
Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy
Mutations that disrupt the clearance of damaged mitochondria via mitophagy are causative for neurological disorders including Parkinson's. Here, we identify a Mitophagic Stress Response (MitoSR) activated by mitochondrial damage in neurons and operating in parallel to canonical Pink1/Parkin-dependent mitophagy. Increasing levels of mitochondrial stress trigger a graded response that induces the concerted degradation of negative regulators of autophagy including Myotubularin-related phosphatase...