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Predictive value of different muscle power normalization methods for mobility limitations in community-dwelling older adults: A cross-sectional analysis from the longevity check-up 8+ study

4 months ago
CONCLUSIONS: Relative muscle power showed superior predictive performance for self-reported walking difficulty, as an indicator of mobility limitation, compared to other normalization methods. Future longitudinal studies are needed to confirm these findings and explore their relevance for other clinically meaningful outcomes.
Stefano Cacciatore

Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

4 months ago
Traumatic brain injury (TBI) increases one's risk of developing Alzheimer's disease and tauopathy. Yet, the mechanisms linking TBI to neurodegenerative disease remain poorly defined. Mounting recent evidence indicates that defects in brain lymphatic drainage contribute to multiple neurodegenerative diseases. Here, we investigated whether promoting brain lymphatic drainage recuperation following TBI via treatment with the lymphangiogenic factor vessel endothelial growth factor C (VEGFC) mitigates...
Ana Royo Marco