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Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice
Aging, a major risk factor for numerous diseases, is associated with significant transcriptional changes across organs. However, the age of onset, extent of transcriptomic changes and how they unfold are not fully understood. We performed bulk RNA sequencing on eight organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen, and testis) from male C57BL/6J mice across much of the murine lifespan covering 3-, 5-, 8-, 14-, 20- and 26-month-old animals. Our analysis revealed that...
Context-Dependent Roles of ANGPTL2-Mediated Inflammaging in Tissue Homeostasis, Pathological Tissue Remodeling, and Longevity
Chronic inflammation is a key driver of aging-related diseases, obesity-associated metabolic disorders, and tumor progression. Aging and obesity contribute to the accumulation of senescent cells, which secrete senescence-associated secretory phenotype (SASP) factors that promote tissue remodeling and chronic inflammation. Here, we investigated the pathological roles of angiopoietin-like protein 2 (ANGPTL2), a potential SASP factor, in a mouse model of high-fat diet-induced premature aging. We...
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Getting to the (square) root of stock-market swings
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Socioeconomic reforms are needed to address disparities for the aging rural-to-urban migrant workforce in China
Evaluating music interventions to treat depression in people living with dementia
Chinese nuclear fusion reactor pushes plasma past crucial limit: what happens next
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Far from the icy Arctic, ancient South Americans hunted whales using whalebone tools
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Alzheimer's drug developer accuses companies it hired of providing "medically impossible" results.
State-specific enhancer landscapes govern microglial plasticity
Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging, and disease. Whether these microglial subsets represent ontogenically separate lineages of cells or are manifestations of plastic changes in microglial states downstream of some converging signals is unknown. Furthermore, despite the well-established role of enhancer landscapes underlying the identity of microglia, the extent to which histone...
Calcium overload induced mitochondrial and lysosomal dysfunction is regulated by Tousled-like kinase in a-synucleinopathy
As a pathological hallmark of Parkinson's disease (PD), a-synucleinopathy induces various cellular damages, including calcium overload, mitochondrial and autophagic dysfunction, ultimately resulting in dopaminergic neuron death. However, the hierarchy of these detrimental events remains unclear. It is well established that a-synuclein can induce calcium overload through diverse mechanisms. To assess whether calcium overload plays a crucial detrimental role, we established a calcium overload...