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These are the 20 most-studied bacteria — the majority have been ignored
Mind matters: investigating academia’s ‘mental health crisis’
Rising stars in AI use robotics and automation to accelerate their work
How the brain cleans itself during deep sleep
Voter turnout drives margins of victory ― if elections are fair
Jimmy Carter obituary: former US president who dedicated his life after office to peace, human rights and global health
Superstable lipid vacuoles endow cartilage with its shape and biomechanics
Science, Volume 387, Issue 6730, January 2025.
Sexually dimorphic dopaminergic circuits determine sex preference
Science, Volume 387, Issue 6730, January 2025.
Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy
Science, Volume 387, Issue 6730, January 2025.
Local genetic adaptation to habitat in wild chimpanzees
Science, Volume 387, Issue 6730, January 2025.
NASA lab and historic observatory narrowly escape LA fire damage
Workers at Jet Propulsion Laboratory and Mount Wilson Observatory made preparations for wildfires
U.S. Forest Service pulls plug on controversial plan to protect old growth
The Biden administration had aimed to create a nationwide approach to protecting the most mature forests from fire, disease, and logging
Over the past 2 years, Earth got hotter faster than ever before
El Niño and declining reflectivity brought a warming surge
Ancient fish fossil suggests ‘living skeletons’ evolved 460 million years ago
X-ray analysis of bony scale shows vertebrates developed ability to remodel and repair bone much earlier than thought
Energy megaproject in Chile threatens the world’s largest telescopes
Glare from proposed green hydrogen plant could degrade views of distant universe
People who can’t picture images in their ‘mind’s eye’ still represent them in their brains
Imaging study of people with aphantasia reveals differences—but not a complete deficit—in visual processing area
Starved of sediment, an iconic piece of the Mississippi River delta could vanish
The Bird's Foot, critical for shipping and wildlife, is “one of the most threatened places in America”
The pathobiology of neurovascular aging
As global life expectancy increases, age-related brain diseases such as stroke and dementia have become leading causes of death and disability. The aging of the neurovasculature is a critical determinant of brain aging and disease risk. Neurovascular cells are particularly vulnerable to aging, which induces significant structural and functional changes in arterial, venous, and lymphatic vessels. Consequently, neurovascular aging impairs oxygen and glucose delivery to active brain regions,...
Brain aging and rejuvenation at single-cell resolution
Brain aging leads to a decline in cognitive function and a concomitant increase in the susceptibility to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. A key question is how changes within individual cells of the brain give rise to age-related dysfunction. Developments in single-cell "omics" technologies, such as single-cell transcriptomics, have facilitated high-dimensional profiling of individual cells. These technologies have led to new and comprehensive...
Biomarker Detection and Therapy of Parkinson's and Alzheimer's disease using upconversion based approach: A Comprehensive Review
Neurodegenerative diseases (NDs) are debilitating disorders characterized by the progressive and selective loss of function or structure in the brain and spinal cord. Both chronic and acute forms of these diseases are associated with significant morbidity and mortality, as they involve the degeneration of neurons in various brain regions. Misfolding and aggregation of amyloid proteins into oligomer and β-sheet rich fibrils share as common hallmark and lead to neurotoxicity. Unfortunately,...