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Population size interacts with reproductive longevity to shape the germline mutation rate

3 months 3 weeks ago
Mutation rates vary across the tree of life by many orders of magnitude, with fewer mutations occurring each generation in species that reproduce quickly and maintain large effective population sizes. A compelling explanation is that large effective population sizes facilitate selection against weakly deleterious "mutator alleles" such as variants that modulate cell division or interfere with the molecular efficacy of DNA repair. However, while the fidelity of a single cell division largely...
Luke Zhu

The Association Between Nutritional Status, Diet Quality, and Sleep Quality Among the Elderly in Jordan: A Cross-Sectional Study

3 months 3 weeks ago
Background: The percentage of the elderly population has increased worldwide. It has been estimated that environmental factors such as eating habits, sleep quality, and physical activity could be responsible for up to 75% of the aging process. Aims: To assess the nutritional status, diet quality, and sleep quality among the elderly in Jordanian. Methods: In a cross-sectional study targeting the Jordanian elderly, 426 participants agreed to participate. Sociodemographic data, anthropometric...
Shadan Al-Tal