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For the first time, there’s a special prize for a research-themed dance generated by an artificial intelligence program

Team says it has hit on an explanation for heartbreaking “lip outs”

House of Lords committee urges government to stem exodus of science and technology companies

Scientists fear merger of Department of Energy advisory committees that gave them their voices at agency

Satellite imagery reveals an unexpected shift in tree lines—but it may not have anything to do with climate change

Prevention of Alzheimer disease (AD) is a medical challenge owing to its complex pathogenesis, which involves amyloid-β (Aβ) and tau aggregation, neuroinflammation and progressive neurodegeneration. Development of disease-specific biomarkers has transformed our ability to detect AD pathology early, enabling more accurate diagnosis, monitoring and the development of targeted disease-modifying therapies. Consequently, primary and secondary prevention of AD have become feasible goals. In this...

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Physical inactivity is a recognized modifiable risk factor for Alzheimer's disease (AD), yet its relationship with progression of AD pathology in humans remains unclear, limiting the effective translation into prevention trials. Using pedometer-measured step counts in cognitively unimpaired older adults, we demonstrated an association between higher physical activity and slower cognitive and functional decline in individuals with elevated baseline amyloid. Importantly, this beneficial...

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CONCLUSION: HLS induced segment-specific changes in the aged intestine, with atrophic and inflammatory alterations in the ileum and increased markers of inflammation and oxidative stress in the colon. These findings highlight the need for targeted interventions to preserve gastrointestinal health in immobilized elderly patients.