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The seminal fluid protein SFP-1 regulates mated hermaphrodite aging and fat metabolism in C. elegans
Across the evolutionary spectrum, sexual interactions can significantly influence the physiology and somatic aging in various species. In Caenorhabditis, male pheromones, sperm, and seminal fluid shorten the lifespan of hermaphrodites through different mechanisms. However, the specific male seminal fluid proteins responsible for this effect remain unidentified. Here, we find that several of the previously observed physiological changes in mated hermaphrodites require a newly-identified seminal...
The effect of kinesiophobia and successful aging on quality of life in older adults: machine learning approach
CONCLUSION: In this study, it was found that quality of life decreased with increasing kinesiophobia, whereas quality of life increased with increasing level of successful aging. Longitudinal studies on quality of life in the elderly are recommended.
Birth size modifies longitudinal associations between midlife educational level and physical function at late-life for men and women
CONCLUSION: Our results imply that for those born small, having lower educational level is associated with having worse physical function at late-life, partly through less physical activity throughout the life-course.
Government-Implemented population osteoporosis screening in rural china: achieving universal coverage with portable DXA
CONCLUSIONS: Government-procured pDXA enables cost-effective universal OP screening in resource-limited rural areas. Scaling this model requires culturally adapted education (e.g., Wu Chinese dialect audiovisual materials) and tiered medication subsidies for groups with low medical payment capacity, aligning with the UN Decade of Healthy Aging (United Nations, UN Decade of Healthy Aging 2021-2030, World Health Organization, 2020).
Daily briefing: The secret language of plants
Trust and science: the essential elements missing from plastics treaty talks
Glowing sperm helps to reveal secrets of mosquito sex
Open-source protein structure AI aims to match AlphaFold
Taiwan invests in genetic resource for health
What now for the global plastics treaty?
Plants have a secret language that scientists are only now starting to decipher
Environmental treaties are paralysed — here’s how we can do better
Ethics must keep pace with embryo research
Treat children as citizen co-researchers in health technology
Universities can harness AI to make learning intuitive
A limerick competition celebrates science through rhyme
Don’t overlook the plastic footprint of fireworks
AI hallucinates because it’s trained to fake answers it doesn’t know
Teaching chatbots to say “I don’t know” could curb hallucinations. It could also break AI’s business model
Man’s pig kidney fails just shy of setting record
The xenotransplant, from a gene-edited pig, had survived for nearly 9 months in Tim Andrews
Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer's disease pathology
Hippocampal degeneration is a feature of both normal aging and Alzheimer's disease (AD). Prior to macroscopic degeneration, microstructural changes occur such as demyelination, iron deposition, or subtle atrophy, which can be characterized in vivo using MRI. We topographically mapped measures of microstructure and macrostructure across the unfolded surface of the hippocampus in 224 healthy older adults at risk for AD (aged 57 to 87) and 37 younger adults (aged 18 to 37). We describe three...