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Longevity steps on the cGAS
Science, Volume 390, Issue 6769, Page 126-127, October 2025.
In Other Journals
Science, Volume 390, Issue 6769, Page 142-143, October 2025.
Learning from my stutter
Science, Volume 390, Issue 6769, Page 210-210, October 2025.
SALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advance
Science, Volume 390, Issue 6769, Page 188-194, October 2025.
Wavefront shaping enables high-power multimode fiber amplifier with output focus
Science, Volume 390, Issue 6769, Page 173-177, October 2025.
Tropical forest carbon offsets deliver partial gains amid persistent over-crediting
Science, Volume 390, Issue 6769, Page 182-187, October 2025.
Photo-induced nonvolatile rewritable ferroaxial switching
Science, Volume 390, Issue 6769, Page 195-198, October 2025.
Total solar eclipse triggers dawn behavior in birds: Insights from acoustic recordings and community science
Science, Volume 390, Issue 6769, Page 152-155, October 2025.
Anion sublattice design enables superionic conductivity in crystalline oxyhalides
Science, Volume 390, Issue 6769, Page 199-204, October 2025.
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Science, Volume 390, Issue 6769, Page 156-163, October 2025.
Greater noctule bats prey on and consume passerines in flight
Science, Volume 390, Issue 6769, Page 178-181, October 2025.
The lithium dilemma
Science, Volume 390, Issue 6769, Page 136-136, October 2025.
The complicated legacy of antibiotics
Science, Volume 390, Issue 6769, Page 137-137, October 2025.
What’s it like to tell someone she won a Nobel Prize?
Science chats with photographer Lindsey Wasson, who captured how Nobel winner Mary Brunkow reacted to life-changing news
In mind-bending twist, ‘magic’ mushrooms evolved twice independently
Study identifies entirely new suite of enzymes that can make psilocybin
These ‘ghost flowers’ thrive without photosynthesis. One scientist is learning how
Japanese botanist Kenji Suetsugu studies plants that steal carbon and nutrients from soil fungi
Journals and publishers crack down on research from open health data sets
PLOS, Frontiers, and others announce policies trying to stem the tide of suspect research
AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
The functional difference between the two catalytic subunits, α1 and α2, of AMP-activated protein kinase (AMPK) complexes remains elusive. Herein, we report that AMPKα2 specifically transduces amino acid insufficiency signals to protein synthesis. Low amino acid levels, high protein levels, and reduced phosphorylation of AMPKα threonine 172 (p-T172) are observed in blood samples in patients with Alzheimer's disease (AD) from a cohort of 1,000,000 Chinese individuals. Loss of α2, but not α1,...
Extracellular vesicle-based biosensors for Alzheimer's disease: A new frontier in precision diagnostics
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, remains a diagnostic challenge due to its asymptomatic early stages and the lack of reliable, non-invasive biomarkers. Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-sized membrane-bound particles released by cells into biological fluids and have emerged as promising carriers of disease-specific biomarkers. These vesicles reflect the physiological and pathological state of their parental cells,...
Apraxic deficits in Alzheimer's disease are associated with altered dynamic connectivity in praxis-related networks
Apraxia is a common symptom in Alzheimer's disease (AD) that reduces autonomy and quality of life. However, the neural basis underlying apraxia in AD, for example, reflected by functional connectivity (FC) alterations, remains unexplored. We investigated static and dynamic FC using resting-state functional imaging in 14 patients with biomarker-confirmed AD pathology and 14 matched healthy participants. FC was estimated as average (static) and short-term (dynamic) connectivity strengths between...