Aggregator
Age-stratified genomic analyses reveal population-specific genetic determinants of exceptional longevity in Taiwan
Human longevity arises from complex genetic and environmental interactions, yet the genetic basis of survival to extreme old age remains underexplored in Asian populations. We performed genome-wide association studies (GWAS) in a Taiwanese cohort, defining survival thresholds at ≥ 85, ≥ 90, and ≥ 95 years, and validated significant loci in an independent cohort. Multiple loci, including ZNF806, NUAK1, TANC1, SLC22A3, PTPRD, and PCSK2, were associated with longevity, of which 14 replicated with...
The Bright Side of Life: Optimism and Risk of Dementia
CONCLUSION: Higher optimism was associated with a lower incidence of dementia. These findings suggest a potential value of optimism in supporting healthy aging, which could be considered in future research on dementia prevention initiatives.
Systemic proteomic and organ aging signatures associated with plasma Abeta oligomerization in a Korean cohort: a cross-sectional study
CONCLUSION: Our findings demonstrated OAβT as a reflection of systemic changes linked to early AD pathology. Moreover, the influence of medications and systemic aging on OAβT values pointed to the potential avenues for intervention and emphasized the importance of considering systemic factors in AD pathogenesis and treatment.