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RANK drives structured intestinal epithelial expansion during pregnancy
Watch this bird-inspired drone leap into the air
Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Author Correction: A virally encoded tRNA neutralizes the PARIS antiviral defence system
Author Correction: Carbon dioxide capture from open air using covalent organic frameworks
Author Correction: Autoregulation in rats with transplanted supernumerary kidneys
Age as an ingredient of household food waste
Science could solve some of the world’s biggest problems. Why aren’t governments using it?
Advising governments about science is essential but difficult. So train people to do it
Exis memoria
How to ensure only dying cells rupture
A step-by-step guide to landing your next job in science
Sick animals suggest COVID pandemic started in Wuhan market
Trump picks billionaire astronaut to lead NASA
Jared Isaacman has twice flown in space in capsules made by Elon Musk’s rocket company
These spiders capture their prey with deadly accurate slingshot traps
Vibrations from flying insects cue ray spiders to deploy web “cones”
Unusual genetic results in prenatal tests can also flag cancers—in the mom
A new study found lymphomas, colon cancer, and breast cancer following rare fetal test result during pregnancy
Mysterious radio pulses traced to dance of stellar dwarfs
Languorous cosmic beats could be generated by magnetic forces between orbiting stars
‘It felt very icky’: This scientist’s name was used to write fake peer reviews
Elsevier retracts dozens of journal articles that were published based on “fictitious” reviews
beta-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). We identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility. βHB primarily provides ATP substrate during periods of reduced glucose availability, and regulates other cellular processes through protein interactions. We demonstrate βHB-induced protein insolubility is not dependent on covalent protein modification, pH, or solute load, and is observable in mouse brain in vivo after delivery of a...
Extracellular vesicle-packed microRNAs profiling in Alzheimer's disease: The molecular intermediary between pathology and diagnosis
MicroRNAs (miRNAs), referring to a type of non-coding RNAs functioning in various biological processes, participate in the pathophysiology of Alzheimer's disease (AD) through increasing amyloid-beta (Aβ) production, enhancing Tau phosphorylation, and inducing neuroinflammation. Meanwhile, extracellular vesicles (EVs) have been suggested as promising carriers of AD biomarkers as they possess the ability to transmit information from cerebral tissue to peripheral blood. Inspired by the above...