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Science, Volume 388, Issue 6749, Page 869-875, May 2025.

Science, Volume 388, Issue 6749, Page 876-880, May 2025.

Science, Volume 388, Issue 6749, Page 881-888, May 2025.

Science, Volume 388, Issue 6749, Page 859-863, May 2025.

Science, Volume 388, Issue 6749, Page 850-853, May 2025.

Science, Volume 388, Issue 6749, Page 822-822, May 2025.

Science, Volume 388, Issue 6749, Page 823-823, May 2025.

Drug combination targeting lax airways is nearing an FDA submission

Science speaks with conservation scientist Kent Redford about why microbes need protection from extinction—and how to achieve it

Management tried to quash outpouring of support for beleaguered agency

Preprint reporting common ground among researchers on smartphones and teen mental health is premature and flawed, critics say

New study of a pathogen’s Bronze Age spread challenges longstanding links between disease and early agriculture

Exotic materials with bizarre electron behavior could pave the road to revolutionary technologies

Reports of false negatives spur World Health Organization to issue internal memo, but the company denies problems

Devices that mimic giant acoustic cameras can spy animal burrows, explosive mines, and metallic deposits

Sexual dysfunction (SD) is a common non-motor symptom in Parkinson's disease (PD) that substantially reduces patients' quality of life. However, the underlying neural mechanisms of SD in PD remain poorly understood. This study aimed to investigate the role of functional abnormalities in brain regions with dopaminergic innervation in male PD patients with SD, using resting-state functional magnetic resonance imaging (rs-fMRI). A total of 34 male PD patients were enrolled. The bilateral caudate,...

The associations of β-amyloid (Aβ) and tau deposition with white matter (WM) degeneration in Alzheimer's disease (AD) remain inadequately elucidated. We investigate baseline and longitudinal changes of microstructural fractional anisotropy (FA) and macrostructural white matter hyperintensities (WMHs) and their relationships with Aβ and tau positron emission tomography (PET) and vascular risk factors in different Aβ/tau stages defined by PET imaging. Lower levels and faster decline rates of FA...

The sense of smell is essential for human perception. Olfactory function declines with increasing age, affecting a substantial portion of the elderly population, and this decline is more pronounced in men. This reduction can be attributed to anatomical and degenerative changes in the brain and olfactory receptors. There is robust clinical evidence indicating an association between olfactory perception decline/deficit (OPD) and major neurodegenerative diseases, with severe deficits observed in...

The salivary gland (SG) is vital for oral function and overall health through secretion of saliva. However salivary dysfunction due to aging, medications, autoimmune disorders, and cancer treatments poses significant challenges. We established the first diverse and clinically annotated salivary regenerative biobank at Mayo Clinic to study salivary gland stem/progenitor cells (SGSPCs). Optimization of cell isolation and progenitor assays revealed SGSPCs enriched within the CD24/EpCAM/CD49f+ and...

Lymph nodes (LN) are the key organs in charge of long-term maintenance of naïve lymphocytes and their initial, primary activation upon infection. Accumulating evidence indicates that LN stromal cells undergo degenerative changes with aging that critically impair LN function, including the generation of protective primary immune responses. The nature of these defects remains incompletely understood. We here demonstrate that age-related LN stromal changes manifest themselves in mitochondrial...