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Does Frailty Predict Cognitive and Functional Deficits After Nine Years?
CONCLUSIONS: Higher age and lower education at baseline were predictors of cognitive and functional deficits after 9 years, whereas frailty was not. Further longitudinal studies should be conducted to elucidate the factors predicting cognitive and functional decline in low-and middle-income countries.
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO(2max)), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcription factors functioning as activators, synergizing with DNA methylation to regulate gene...
Predicting brain age for veterans with traumatic brain injuries and healthy controls: an exploratory analysis
BACKGROUND: Traumatic brain injury (TBI) is associated with increased dementia risk. This may be driven by underlying biological changes resulting from the injury. Machine learning algorithms can use structural MRIs to give a predicted brain age (pBA). When the estimated age is greater than the chronological age (CA), this is called the brain age gap (BAg). We analyzed this outcome in men and women with and without TBI.
Mirodenafil improves cognitive function by reducing microglial activation and blood-brain barrier permeability in ApoE4 KI mice
INTRODUCTION: Alzheimer's disease (AD) has significant public health concerns in the aging society. AD can compromise brain function and lead to severe neurological abnormalities associated with dementia. The human Apolipoprotein E (ApoE4) gene is a strong risk factor for AD. However, comprehensive analyses and improvements of mouse models expressing ApoE4 remain largely unexplored.
Will your car hit that deer? Depends on your headlight bulbs—and the deer’s personality
Halogen bulbs more reliably catch deer’s attention, but whether the animals flee or freeze comes down to individual temperament
Final NSF budget proposal jettisons one giant telescope amid savage agencywide cuts
Trump’s 57% proposed cut to agency would drop grant success rates to 7% and gut education and training
‘Devastating’: NIH cancels future funding plans for HIV vaccine consortia
Researchers decry agency’s decision just as new leads reinvigorate search for long-sought vaccine
Daily briefing: The sweet smell of outer space
NIH grant cuts will axe clinical trials abroad — and could leave thousands without care
See the Milky Way dazzle during a lunar eclipse — May’s best science images
Gender equality in research publishing is a responsibility for everyone
CRISPR helps to show why a boy felt no pain
Underwater kelp forests are losing a turf war
Pace of aging matters for healthspan and lifespan in older adults
Salary negotiations: a guide for scientists
Audio long read: Three ways to cool Earth by pulling carbon from the sky
US–China tariff war threatens global public health
Dozens of active and planned NASA spacecraft killed in Trump budget request
Proposal would end nearly all new major science missions
NIH funding policy deals new blow to HIV-related trial networks
Halt to foreign “subawards” disrupts ongoing global studies and has researchers scrambling to fulfill ethical obligations to trial volunteers
Trump officials downplay fake citations in high-profile report on children’s health
References to phantom studies comes after White House pledge to practice “gold standard” science