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The 'mitochondrial guardian' α-amyrin links colourful fruit consumption to cognitive resilience
Mitochondrial quality control is essential for maintaining neuronal function and resilience during aging, yet pharmacological strategies that effectively restore mitophagy to maintain mitochondrial homeostasis remain limited. Emerging evidence suggests that dietary molecules may influence mitochondrial health, although the underlying mechanisms are largely unknown. Here, we summarize our recent finding whereby we have identified a robust mitophagy inducer: α-amyrin (αA). This molecule is a...
Volunteer Leadership in Older Adults' Self-Guided Learning Groups in Taiwan: Motivations and Management Processes Through an Ecological Lens
As global populations age, active aging and lifelong learning have become critical policy objectives. In Taiwan, the Ministry of Education (MOE) promotes Older Adults' Self-Guided Learning Groups (OASLGs); however, the sustainability of these groups relies heavily on volunteer leaders. This study investigates the motivations and management processes of "Excellent Leaders" in OASLGs using a qualitative approach. Drawing on Bronfenbrenner's ecological systems theory, we analyzed semistructured...
Daily briefing: The heart’s pumping motion seems to keep cancer at bay
How much for a fake authorship? Ad database reveals secrets of scientific fraud
Inside the evidence revolution — how decision-making became data driven
Cosmic-ray detection heralds era of mega-observatories for neutrinos
Connecting fragmented aging research through the European Federation for Aging Research
The memory dealer of Old Jeddah
Hit a glitch in your research? Some ‘night science’ thinking could move it forward
Brain tissue near tumours is loaded with plastic
From bats at dusk to asteroid quests: Books in brief
Author Correction: A µ-opioid receptor superagonist analgesic with minimal adverse effects
Author Correction: Commensal yeast promotes <i>Salmonella</i> Typhimurium virulence
Closure of China’s influential journal ranking leaves academics reeling — what will take its place?
After pulling vaccine study, Bhattacharya criticizes long-running CDC publication
Agency’s temporary director says Morbidity and Mortality Weekly Report needs external reviewers
Can Starship succeed where the space shuttle struggled?
As SpaceX readies its latest megarocket, engineer Stephen Whitmore explains why atmospheric reentry pushes materials to their limits
UK Biobank faces questions about data security after latest breach
Experts say the lapse highlights that even new measures to control access did not safeguard deidentified patient information
Abrupt change to European funder’s rules leaves researchers shut out
Flood of proposals to European Research Council—perhaps unleashed by AI—means unsuccessful applicants must wait longer to reapply
Organelle interactome disruption: The systemic pathological mechanisms and therapeutic prospects of mitochondria-lysosome-ER crosstalk in Alzheimer's disease
The traditional pathological framework of Alzheimer's disease (AD) primarily focuses on the accumulation of β-amyloid (Aβ) and tau proteins. However, therapeutic strategies targeting these molecules have repeatedly encountered setbacks in clinical translation. Recent studies have progressively revealed that the dynamic interaction network among intracellular organelles plays a central role in the pathogenesis of AD. This systematic review examines the independent dysfunctions of three key...
TNMD BRICHOS domain attenuates tau pathology and memory deficits in a mouse model of tauopathy
The aberrant aggregation of tau leads to loss of its physiological functions and gain of toxic functions, and plays a crucial role in the pathogenesis of tauopathies including Alzheimer's disease (AD). Targeting tau aggregation is considered a promising strategy for treating tauopathies. The BRICHOS family consists of a variety of proteins containing the BRICHOS domain. Certain endogenous BRICHOS domains may inhibit the pathological aggregation of disease-associated proteins. However, the...