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Genesis and regulation of C-terminal cyclic imides from protein damage
C-Terminal cyclic imides are posttranslational modifications that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible protein damage. These protein damage events are recognized and removed by the E3 ligase substrate adapter cereblon (CRBN), indicating that these aging-related modifications may require cellular quality control mechanisms to prevent deleterious effects. However, the factors that determine protein or peptide...
Social Connections, Leukocyte Telomere Length, and All-Cause Mortality in Older Adults From Costa Rica: The Costa Rican Longevity and Healthy Aging Study (CRELES)
OBJECTIVES: To examine the association of social connections with blood leukocyte telomere length (LTL) and all-cause mortality in older Costa Ricans.
Salidroside Improves Oocyte Competence of Reproductively Old Mice by Enhancing Mitophagy
The decline of oocyte quality with advanced maternal age has a detrimental effect on female fertility. However, there is limited knowledge of therapeutic options and their mechanisms to improve oocyte quality in reproductively older women. In this study, we demonstrated that supplementation of salidroside improves the oocyte quality of reproductively old mice. Salidroside improved the maturation, fertilization, and developmental competence of oocytes from reproductively old mice by maintaining...
Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice
The current mechanism by which aging reduces salivary secretion is unknown. This study investigates the mechanism of aging-related submandibular (SMG) dysfunction and evaluates the therapeutic potential of dental pulp stem cell-derived exosomes (DPSC-exos). We found that the stimulated salivary flow rate was significantly reduced in naturally aging and D-galactose-induced aging mice (D-gal mice) compared to control mice. Acinar atrophy and periductal fibrosis in SMGs and parotid glands (PGs)...
Daily briefing: Earth breaches 1.5 °C climate limit for the first time
Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence
Earth breaches 1.5 °C climate limit for the first time: what does it mean?
Does fact-checking work? What the science says
These are the 20 most-studied bacteria — the majority have been ignored
Mind matters: investigating academia’s ‘mental health crisis’
Rising stars in AI use robotics and automation to accelerate their work
How the brain cleans itself during deep sleep
Voter turnout drives margins of victory ― if elections are fair
Jimmy Carter obituary: former US president who dedicated his life after office to peace, human rights and global health
Superstable lipid vacuoles endow cartilage with its shape and biomechanics
Science, Volume 387, Issue 6730, January 2025.
Sexually dimorphic dopaminergic circuits determine sex preference
Science, Volume 387, Issue 6730, January 2025.
Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy
Science, Volume 387, Issue 6730, January 2025.
Local genetic adaptation to habitat in wild chimpanzees
Science, Volume 387, Issue 6730, January 2025.
NASA lab and historic observatory narrowly escape LA fire damage
Workers at Jet Propulsion Laboratory and Mount Wilson Observatory made preparations for wildfires
U.S. Forest Service pulls plug on controversial plan to protect old growth
The Biden administration had aimed to create a nationwide approach to protecting the most mature forests from fire, disease, and logging