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Worried about regional security, bloc pushes forward on controversial “dual-use” approach

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive dysfunction, with spatial memory impairments among the earliest detectable deficits. The dentate gyrus (DG), a critical region for spatial discrimination, exhibits functional alterations in patients with AD. Adult-born granule cells (abGCs) with higher intrinsic excitability are involved in DG-dependent spatial memory. However, it remains unclear the changes in intrinsic excitability of abGCs and...

Alzheimer's disease (AD) diagnosis hinges on detecting amyloid beta (Aβ) plaques and neurofibrillary tau (τ) tangles, typically assessed using PET imaging. While accurate, these modalities are expensive and not widely accessible, limiting their utility in routine clinical practice. Here, we present a multimodal computational framework that integrates data from seven distinct cohorts comprising 12, 185 participants to estimate individual PET profiles using more readily available neurological...

CONCLUSIONS AND IMPLICATIONS: Regardless of sexual orientation, receiving care at home was the most preferred option, followed by moving to an assisted living facility. In terms of the type of home care, professional home care and a mix of formal and informal care were the most preferred options. Surprisingly, informal care was preferred by only 53.3% of people. Our results revealed that preferences for care settings (eg, own home, nursing home) and preferences for type of care (eg, informal...

CONCLUSIONS AND IMPLICATIONS: Enhanced CRF and muscle strength could offset the risk of premature health span termination associated with accelerated biological aging. Our findings suggest that biological aging rates should be considered in personalized fitness interventions to optimize health span. Public health strategies should prioritize cardiorespiratory and muscular fitness to mitigate aging-related health risks.

The placebo effect, or the positive effects observed after an inert treatment which result from patients' expectations for the therapy, is well documented in human medicine. However, in veterinary medicine, where owner's expectations serve as a proxy for their pets, it remains underexplored, particularly for elderly dogs with cognitive decline. To address this gap, we examined 21 dogs (mean age: 12.85 years, SD: 1.46) from a placebo group in a randomized controlled trial (RCT) and compared their...

Anthropogenic climate change is driving summer heat toward more humid conditions, accompanied by more frequent day-night compound heat extremes (high temperatures during both day and night). As the fast-warming and aging continent, Europe faces escalating heat-related health risks. Here, we projected future heat-related mortality in Europe using a distributed lag nonlinear model that incorporates humid heat and compound heat extremes, strengthened by a health risk-based definition of extreme...

Enigmatic dinucleoside tetraphosphates, known as 'alarmones' (Np(4)Ns), have recently been shown to function in bacteria as precursors to Np(4) caps on transcripts, likely influencing RNA longevity and cellular adaptation to stress. In proteobacteria, ApaH is the predominant enzyme that hydrolyzes Np(4)Ns and decaps Np(4)-capped RNAs to initiate their 5'-end-dependent degradation. Here we conducted a biochemical and structural study to uncover the catalytic mechanism of Escherichia coli ApaH, a...

While it is well-documented that plasma oxytocin (OXT) levels decline with age, the underlying mechanisms remain elusive. This study aimed to elucidate the physiological mechanisms contributing to this age-related decrease in plasma OXT and the possible use of OXT supplementation on improving age-related decline of neural function. Comparing young (9 weeks) and aged (> 45 weeks) mice, aged mice showed reduced plasma OXT levels, an increase in the inflammation marker hs-CRP, and decreased...

Biochar application offers significant potential to enhance food security and mitigate climate change. However, most evidence stems from short-term field experiments (≤3 y), leaving uncertainty about the long-term sustainability of these benefits, especially with annual biochar additions to soils. To address this knowledge gap, we analyzed a global dataset from 438 studies (3,229 observations) and found that long-term annual biochar application (≥4 y) not only sustains but often enhances its...

To delay social and healthcare utilisation among the ageing population, there is an increasing focus on the role of health-promoting lifestyle adopted at an individual and/or community level. Longevity is generally viewed as the ultimate outcome of health, although a high life expectancy does not necessarily go together with health and/or a health-promoting lifestyle. The potential coherence between longevity, health and lifestyle may vary in different cultural, political, social and economic...

The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans. These transcription factors coordinate nutrient sensing with carbohydrate and lipid metabolism across the evolutionary spectrum. While most studies have focused on the downstream outputs, little is known about the upstream inputs that regulate these transcription factors in a live organism. Here, we found that knockdown of...

Evidence connecting skin aging to functional decline and systemic aging biomarkers is lacking. This study investigated how skin-aging biomechanics were associated with changes in intrinsic capacity (IC), a marker of healthy aging. We also explored their links with biological aging clocks (epigenetic and inflammatory clocks) and potential moderating effects on the skin-IC relationship. Baseline skin elasticity and viscoelasticity were measured in 441 INSPIRE-T participants aged 20 to 93 (59.9%...