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Genesis and regulation of C-terminal cyclic imides from protein damage

3 months 2 weeks ago
C-Terminal cyclic imides are posttranslational modifications that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible protein damage. These protein damage events are recognized and removed by the E3 ligase substrate adapter cereblon (CRBN), indicating that these aging-related modifications may require cellular quality control mechanisms to prevent deleterious effects. However, the factors that determine protein or peptide...
Wenqing Xu

Salidroside Improves Oocyte Competence of Reproductively Old Mice by Enhancing Mitophagy

3 months 2 weeks ago
The decline of oocyte quality with advanced maternal age has a detrimental effect on female fertility. However, there is limited knowledge of therapeutic options and their mechanisms to improve oocyte quality in reproductively older women. In this study, we demonstrated that supplementation of salidroside improves the oocyte quality of reproductively old mice. Salidroside improved the maturation, fertilization, and developmental competence of oocytes from reproductively old mice by maintaining...
Jingkai Gu

Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice

3 months 2 weeks ago
The current mechanism by which aging reduces salivary secretion is unknown. This study investigates the mechanism of aging-related submandibular (SMG) dysfunction and evaluates the therapeutic potential of dental pulp stem cell-derived exosomes (DPSC-exos). We found that the stimulated salivary flow rate was significantly reduced in naturally aging and D-galactose-induced aging mice (D-gal mice) compared to control mice. Acinar atrophy and periductal fibrosis in SMGs and parotid glands (PGs)...
Zhuo Chen

Superstable lipid vacuoles endow cartilage with its shape and biomechanics

3 months 2 weeks ago
Science, Volume 387, Issue 6730, January 2025.
Raul Ramos, Kim T. Pham, Richard C. Prince, Leith B. Leiser-Miller, Maneeshi S. Prasad, Xiaojie Wang, Rachel C. Nordberg, Benjamin J. Bielajew, Jerry C. Hu, Kosuke Yamaga, Ji Won Oh, Tao Peng, Rupsa Datta, Aksana Astrowskaja, Axel A. Almet, John T. Burns…

Sexually dimorphic dopaminergic circuits determine sex preference

3 months 2 weeks ago
Science, Volume 387, Issue 6730, January 2025.
Anqi Wei, Anran Zhao, Chaowen Zheng, Nan Dong, Xu Cheng, Xueting Duan, Shuaijie Zhong, Xiaoying Liu, Jie Jian, Yuhao Qin, Yuxin Yang, Yuhao Gu, Bianbian Wang, Niki Gooya, Jingxiao Huo, Jingyu Yao, Weiwei Li, Kai Huang, Haiyao Liu, Fenghan Mao, Ruolin…

Local genetic adaptation to habitat in wild chimpanzees

3 months 2 weeks ago
Science, Volume 387, Issue 6730, January 2025.
Harrison J. Ostridge, Claudia Fontsere, Esther Lizano, Daniela C. Soto, Joshua M. Schmidt, Vrishti Saxena, Marina Alvarez-Estape, Christopher D. Barratt, Paolo Gratton, Gaëlle Bocksberger, Jack D. Lester, Paula Dieguez, Anthony Agbor, Samuel Angedakin,…