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Lifespan and Fecundity Impacts of Reduced Insulin Signalling Can Be Directed by Mito-Nuclear Epistasis in Drosophila
The changing demography of human populations has motivated a search for interventions that promote healthy ageing, and especially for evolutionarily-conserved mechanisms that can be studied in lab systems to generate hypotheses about function in humans. Reduced Insulin/IGF signalling (IIS) is a leading example, which can extend healthy lifespan in a range of animals, but whether benefits and costs of reduced IIS vary genetically within species is under-studied. This information is critical for...
Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer's disease
Alzheimer's disease (AD) represents a continuously advancing neurodegenerative condition distinguished by the unremitting deterioration of cognitive abilities and memory impairment, which significantly hampers daily functioning of life. In the absence of disease modifying treatments, it continues to pose a significant global challenge. Though symptomatic treatment exists, the inherent complexity involved with AD pathogenesis related to Aβ plaques, neurofibrillary tangles, neuroinflammation,...
Inside the quest to make a safer football helmet
New energy-absorbing designs and materials have revolutionized the iconic safety device
Daily briefing: Tumours use neurons as hotline to the brain
This bonobo had a pretend tea party — showing make believe isn’t just for humans
Not just a chip off the old block: nanoparticles reveal odd traits
Internet platforms must be held accountable for their actions
Science, Volume 391, Issue 6785, February 2026.
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function
Science, Volume 391, Issue 6785, February 2026.
Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency
Science, Volume 391, Issue 6785, February 2026.
Gapless pangenome analyses reveal fast Brassica rapa subspeciation
Science, Volume 391, Issue 6785, February 2026.
Why methane surged in the atmosphere during the early 2020s
Science, Volume 391, Issue 6785, February 2026.
DNA origami vaccines program antigen-focused germinal centers
Science, Volume 391, Issue 6785, February 2026.
Multiscale pangenome graphs empower the genomic dissection of mixed-ploidy sugarcane species
Science, Volume 391, Issue 6785, February 2026.
Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes
Science, Volume 391, Issue 6785, February 2026.