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The field of biogerontology has established itself through significant lines of research in recent decades. However, despite early breakthroughs, progress in understanding the aging process has been slow. To push the field forward, new methodologies and technologies are likely needed to unravel the complexity of aging. This meeting brought together leading scientists and innovators to explore some emerging approaches, presenting groundbreaking advancements in four key sessions, culminating in a...

Recognition and elimination of pathogens and cancer cells depend on the adaptive immune system. Thus, accurate quantification of immune subsets is vital for precision medicine. We present immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS), which estimates T cell and B cell fractions, class switching and clonotype diversity from whole-genome sequencing data at depths as low as 5× coverage. By applying ImmuneLENS to the 100,000 Genomes Project, we identify genes enriched with...

CONCLUSION: Tooth loss increases the risk of cognitive decline, and low body weight partially mediates this association.

Parkinson's disease (PD) is a neurodegenerative disease characterized by the death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies that are composed of aggregated α-synuclein (α-Syn). However, the factors that regulate α-Syn pathology and nigrostriatal dopaminergic degeneration remain poorly understood. Previous studies demonstrate cholesterol 24-hydroxylase (CYP46A1) increases the risk for PD. Moreover, 24-hydroxycholesterol (24-OHC), a brain-specific oxysterol...

Fraud undermines Alzheimer's disease research.

CONCLUSION: Home-based CGA improves clinical and process outcomes for community dwelling at-risk older adults. CGA delivered by a comprehensive multidisciplinary team enhances functional status among community-dwelling older adults.