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Fluctuating DNA methylation tracks cancer evolution at clinical scale
Stabilizing effect of amino acids on protein and colloidal dispersions
Programmable antisense oligomers for phage functional genomics
The emergence of globular clusters and globular-cluster-like dwarfs
Human gastroids to model regional patterning in early stomach development
The oldest known lepidosaur and origins of lepidosaur feeding adaptations
Long-range PM<sub>2.5</sub> pollution and health impacts from the 2023 Canadian wildfires
Jelly-filled garment keeps wearers cool when heat and humidity soar
Feeling the heat: fossil-fuel producers linked to dozens of heatwaves
Editorial Expression of Concern: Recovery of learning and memory is associated with chromatin remodelling
Mitochondria-associated condensates maintain mitochondrial homeostasis and promote lifespan
Senescent-like border-associated macrophages regulate cognitive aging via migrasome-mediated induction of paracrine senescence in microglia
Plasma proteomic associations with Alzheimer’s disease endophenotypes
Population aging in Japan offers a warning and a template for action
Scientists take on Trump: these researchers are fighting back
Using biobanks to boost research: a how-to guide
The earth will not consume our bones
‘Incredible’ fossil reveals earliest relative of lizards and their kin
Paleontologists use x-rays to reconstruct ancient reptile bones too fragile to remove from rock
SIRT2 and NAD(+) Boosting Broadly Suppress Aging-Associated Inflammation
Aging leads to chronic inflammation that is linked to aging-associated conditions and diseases. Multiple immune pathways become activated during aging, posing a challenge to effectively reduce aging-associated inflammation. SIRT2, an NAD^(+)-dependent deacetylase, suppresses several immune pathways that become activated during aging and may represent an attractive target to broadly dampen aging-associated inflammation. Here, we show that SIRT2 deficiency leads to increased inflammation governed...
Fluphenazine, an antipsychotic compound, ameliorates Alzheimer's disease by clearing amyloid beta accumulation in C. elegans
The aging population worldwide faces an increasing burden of age-related conditions, with Alzheimer's disease being a prominent neurodegenerative concern. Drug repurposing, the practice of identifying new therapeutic applications for existing drugs, offers a promising avenue for accelerated intervention. In this study, we utilized the yeast Saccharomyces cerevisiae to screen a library of 1760 FDA-approved compounds, both with and without rapamycin, to assess potential synergistic effects on...