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Beyond the blur: Scopolamine's utility and limits in modeling cognitive disorders across sexes - Narrative review

3 months 3 weeks ago
Scopolamine, widely regarded as the gold standard in preclinical studies of memory impairments, acts as a non-selective antagonist of central and peripheral muscarinic receptors. While its application in modeling dementia primarily involves antagonism at the M(1) receptor, its non-selective peripheral actions may introduce adverse effects that influence behavioral test outcomes. This review analyzes preclinical findings to consolidate knowledge on scopolamine's use and elucidate potential...
Angelika Jagielska