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Five reasons why Nepal struggles to attract women into science
Arguments for blind peer review also need to be recognized
Label political AI and audit its hidden costs
Deep brain stimulation data need public oversight
Scientific meetings debate the effect of climate change on future food production
Emotional AI is here — let’s shape it, not shun it
Author Correction: Complex genetic variation in nearly complete human genomes
Publisher Correction: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury
Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology
Pig lung transplanted into a person in world first
Deep-sea worms fight poison with poison to survive in hydrothermal vents
Combining arsenic and sulfide in skin cells forms a less toxic mineral—and turns the animals bright yellow
Bats may mistake wind turbines for open sky, causing deadly collisions
Study may help explain why giant blades kill millions of the animals every year
In a first, pig lung survives and functions—briefly—in a person
Organ transplanted to brain-dead man lasts for more than a week before succumbing to an immune assault
The dopamine stabilizer (-)-OSU6162 attenuates levodopa-induced dyskinesia in the unilateral 6-hydroxydopamine rat model of Parkinson's disease
Levodopa-induced dyskinesia (LID) is a complication that occurs in many patients with Parkinson's disease. (-)-OSU6162 is a clinically tolerable dopamine stabilizer with affinity for both dopaminergic D(2) receptors and serotonergic 5-HT(2A) receptors which has been shown to counteract LID in non-human primates. To investigate whether (-)-OSU6162 can dampen levodopa-induced abnormal involuntary movements in the unilateral 6-OHDA rat model of Parkinson's disease without impairing levodopa-induced...
MicroRNAs in neuroplasticity: a comprehensive review of mechanisms and therapeutic strategies for neurodegenerative diseases
MicroRNAs (miRNAs) have emerged as key regulators of neuroplasticity, influencing essential processes such as neurogenesis, synaptogenesis, and neuroinflammatory responses. This review provides a comprehensive overview of the general roles of miRNAs in neuroplasticity and synthesizes recent insights from both preclinical and clinical studies, including transcriptomic analyses and miRNA profiling, to elucidate the molecular mechanisms by which these miRNAs modulate neuronal function. We have...
Nucleoside reverse transcriptase inhibitors as a therapeutic opportunity to counteract inflammaging and age-related diseases: New evidence from epidemiological data
Nucleoside Reverse Transcriptase Inhibitors (NRTIs), widely used to treat HIV and hepatitis B, have recently been shown to possess anti-inflammatory properties by inhibiting inflammasome activation. Epidemiological studies have revealed a significantly reduced incidence of age-related diseases, such as Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), among patients chronically treated with NRTIs, but not with other classes of antiretroviral drugs. In this short review, we explore...
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function
Alzheimer's disease (AD) and AD-related dementias (AD/ADRD) have a substantial genetic basis, with APOE4 homozygotes increasingly recognized as a distinct genetic subtype. To identify genotype-specific metabolic pathways and modifiable risk factors, we integrated genetic, plasma metabolomic and dietary data from 4,215 women and 1,490 men in prospective cohorts. Here we show that the associations of 57 metabolites with dementia risk varied by APOE4 genotype or other AD/ADRD risk variants. For...
Chronic inflammation and cognitive frailty in older adults: A narrative review
Cognitive Frailty (CF) is a clinical syndrome characterized by the co-occurrence of physical frailty and cognitive impairment in the absence of dementia. This geriatric condition has emerged as a significant contributor to compromised health status and diminished quality of life among aging populations, yet its underlying pathological mechanisms remain incompletely elucidated. Chronic low-grade inflammation, recognized as a hallmark of biological aging, has been implicated in the pathogenesis of...
Effects of Music Imaging on Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial
CONCLUSIONS AND IMPLICATIONS: This study revealed the beneficial effects of music imaging on cognitive function, neuropsychiatric symptoms, sleep quality, and quality of life among older adults with MCI. These findings support the application of music imaging among older adults with MCI with the aim of slowing cognitive decline, improving symptoms, and promoting healthy aging. [The study was registered with the China Clinical Trial Registry (ChiCTR2400081469) and approved by the Ethics Committee...
Frequent Emergency Medical Services Utilization Among Older Patients: Exploration and Automatic Identification Using Natural Language Processing
CONCLUSION AND IMPLICATIONS: An NLP-based model using EMS text data could improve the identification of frequent users. Integration of such tools into prehospital care systems may support earlier identification and tailored intervention strategies for older people frequent in use of acute care.