Aging & Longevity

As the global population ages, multimorbidity has become a critical public health issue. We analyzed 332,012 adults from the UK Biobank (2006-2022) to investigate the association between biological age-measured by the Klemera-Doubal method (KDM-BA) and phenotypic age (PhenoAge)-and a new comorbidity model encompassing physical, psychological, and cognitive disorders, with overall mortality outcomes over a median follow-up of 13.6 years. Logistic regression models examined the association between...

Malvidin-3-galactoside (M3G), an anthocyanin derived from blueberries (Vaccinium myrtillus L.), is recognized for its antioxidant and anti-inflammatory properties. In this study, Drosophila melanogaster was treated with M3G at concentrations of 1, 10, and 100 µM, while control groups received an identical diet without M3G supplementation. Treatment with M3G extended the lifespan of male flies by as much as 5% (p < 0.05). However, in females, certain concentrations of M3G resulted in reduced...

The growing population of childhood cancer survivors (CCSs) experiences a large burden of comorbidities, including a markedly increased risk of diabetes mellitus. Among CCSs, prediabetes and diabetes are important risk factors for subsequent cardiovascular disease, which is a leading cause of premature death in this patient population. The mechanisms underlying their development are multifactorial, and may differ from those in the general population. Emerging evidence from preclinical and...

CONCLUSIONS: This multidimensional approach may enable earlier identification of individuals at risk for functional decline and inform the development of targeted preventive or therapeutic interventions to promote independence and healthy aging.

In both humans and mice, the adrenal gland is a sexually dimorphic organ, but the extent of this diversity throughout development remains unclear. Here, we analyzed the mouse adrenal gland transcriptome at postnatal days 0, 7, 15, 21, 28, 35, and 49 to uncover its transcriptomic trajectory. Sex-dependent differences, indicated by the number of differentially expressed genes, gradually increase over time. Two Y-linked genes are consistently expressed in male adrenal glands, suggesting that...

The genetic basis of naturally occurring variation in organismal senescence and lifespan remains largely unknown. We quantified genome-wide gene expression levels of young and 3-week-old flies of the Drosophila Genetic Reference Panel and performed a systems genetics analysis integrating genomic, transcriptomic, and organismal phenotype variation. Aging had widespread but small effects on nearly the entire transcriptome, which were dependent on the genetic background. Although the co-expression...

Medial ganglionic eminence-derived inhibitory γ-aminobutyric acid (GABAergic) pallial interneurons (MGE-pINs) are essential regulators of cortical circuits, and their dysfunction is associated with neurological disorders. We developed human MGE-pINs from pluripotent stem cells for the treatment of drug-resistant epilepsy. Here, we analyzed xenografted MGE-pINs from human pluripotent stem cells (hMGE-pINs) over the lifespan of host mice in healthy and epileptic environments using single-nuclei...

CONCLUSIONS AND IMPLICATIONS: Social networks, social activities, and social support function as central and bridging roles within the multilayer health ecology model, linking socioeconomic and behavioral factors in MCR. These findings underscore the importance of social relationships as culturally sensitive and modifiable targets for multilevel interventions from a mechanistic perspective, offering a theoretical foundation for practices and policies aimed at slowing MCR progression and...

CONCLUSIONS AND IMPLICATIONS: A social learning theory-based training program can effectively enhance nursing assistants' pressure injury prevention and management competence; however, visual identification skill retention requires reinforcement. This scalable, theory-driven model addresses global workforce training gaps in long-term care, offering actionable strategies to reduce pressure injury incidence and improve care quality for aging populations.

DNA repair, an evolutionarily conserved mechanism essential for restoring genetic homeostasis, has been implicated in aging and longevity by multiple lines of evidence. However, due to the challenges in obtaining human research materials, studies on the interplay between DNA repair and aging rely primarily on laboratory animal models, whose regulatory mechanisms may not fully mirror those in humans. Strikingly, the rate of aging varies by nearly an order of magnitude across humans, ranging from...

Aging is driven by cellular senescence and chronic inflammation, largely mediated by the senescence-associated secretory phenotype (SASP). SASP factors promote inflammaging, impair tissue homeostasis, and contribute to age-related diseases such as cardiovascular disease, neurodegeneration, and cancer. Current anti-aging strategies focus on senolytics or SASP inhibitors, yet these approaches have limitations. We discuss therapeutic plasma exchange (TPE) and selective apheresis, as interventions...

Osteoarthritis (OA) is a common and debilitating joint disorder, with its pathogenesis significantly influenced by factors such as aging and obesity. A critical aspect of OA development is the senescence of chondrocytes, which is characterized by irreversible cell cycle arrest and the secretion of pro-inflammatory molecules, collectively known as the senescence-associated secretory phenotype (SASP). Senescent chondrocytes compromise the maintenance of the extracellular matrix (ECM) and...

CONCLUSIONS: The findings suggest that NUSN4 levels detected in the blood could serve as a potential biomarker for ovarian aging. This provides new insights into the role of mitochondrial dysfunction in reproductive age-related traits and may inform future targeted interventions to slow ovarian aging.

Respiratory syncytial virus (RSV) causes severe respiratory disease in infants and the elderly. However, natural infection fails to induce durable immune protection, and existing mRNA vaccines for older adults exhibit limited long-term efficacy. We developed an antigen engineering strategy inserting ESCRT/ALIX-binding region (EABR) into truncated RSV prefusion F (PreF) cytoplasmic tails to form enveloped virus-like particles (eVLPs). In murine models, PreF-EABR mRNA vaccines elicited higher,...

CONCLUSION: This study highlights the important impact of physical activity and body shape management on sleep disorders in older CMM patients.

ObjectivesUnited States (U.S.) immigrants are rapidly aging, although little is known on how acculturation influences their disability risk.MethodsWe pooled 2000-2018 data (n = 50,075) from the National Health Interview Survey (NHIS) to examine odds of activities of daily living (ADL) disability among middle aged (40-64) and older (65+) immigrants based on three acculturation indicators while accounting for various measures.ResultsAmong middle aged immigrants, citizenship was associated with...

Brain age and epigenetic age (DNAmAge) are 'biological clocks' independently linked to health outcomes. However, the relationship between brain and epigenetic age remains unclear. We used path analysis to investigate relationships between chronological age, DNAmAge, and brain age and explored whether advanced aging in specific brain regions relates to DNAmAge. BrainAge (global and regional) was estimated from brain MRI in 149 participants (ages 20-80). From whole blood, four DNAmAges were...

CONCLUSIONS AND IMPLICATIONS: Findings underscore differences in how LTSS availability and variety relate to unmet care needs for Black and White older adults. Future research should examine these associations in other racial and ethnic minoritized groups.

CONCLUSIONS AND IMPLICATIONS: A substantial subgroup of older Medicare beneficiaries, including both those with and without Medicaid, received paid family care between 2011 and 2022. Especially given direct care workforce shortages, evidence-based expansion of models of paid family care is an important approach to meet the care needs of older adults living in the community.

As human life expectancy continues to rise, ageing and age-related diseases have become critical societal challenges, driving extensive research across genetics, molecular biology, biochemistry, and behavioral sciences. In this context, domestic dogs (Canis lupus familiaris) offer a unique model for ageing research due to their shared environmental exposures with humans, diverse genetic profiles, and relatively short lifespans. This review aims to identify potential biomarkers of ageing in dogs,...