Aging & Longevity

ObjectiveThis study examined the longitudinal effects of social isolation on chronic diseases and depressive symptoms among middle-aged and older adults in South Korea, with attention to gender and age differences.MethodUsing data from three waves of the Korean Longitudinal Study of Aging, longitudinal path analysis was conducted on 5,585 participants.ResultsWomen and older adults showed higher levels of social isolation, chronic diseases, and depressive symptoms, indicating greater...

Speech-in-noise (SIN) perception is a difficult everyday listening task that becomes more difficult with age. Neural tracking of target speech is associated with successful speech perception in clean and noise-degraded listening environments. How aging impacts neural tracking of speech and behavioral decrements in SIN perception remains unclear. To address these questions, we measured neural speech tracking during a continuous SIN perception task in younger and older adults via multichannel...

How cell identity is maintained is a fundamental question, and loss of cell identity is a hallmark of aging associated with multiple age-related diseases. In the adult Drosophila midgut, we identified a posttranscriptional regulatory layer that supervises enterocyte (EC) identity and fails upon aging. Combining single-cell RNA-seq with lineage tracing in aging ECs and classical genetics, we found that aging ECs express genes that unlock the differentiated state. Upon aging, the protein Rogue...

Companion dogs are a valuable geroscience model because they share human environments, develop similar age-related diseases, and have compressed lifespans. The Dog Aging Project (DAP) is a large, prospective cohort designed to investigate intrinsic and extrinsic factors associated with canine aging and longevity. We analyzed 41,047 dogs from the 2024 DAP Curated Data Release with baseline Health and Life Experience Survey (HLES) data and mortality follow-up through 2024. All-cause mortality was...

Neurovascular ageing is a major contributor to cerebrovascular vulnerability and poor stroke outcomes in older adults. Progressive deterioration of the neurovascular unit (NVU), driven by oxidative stress, neurovascular coupling dysfunction, blood-brain barrier (BBB) disruption, inflammageing, cellular senescence, mitochondrial dysfunction, and impaired autophagy compromises neurovascular resilience and increases susceptibility to ischemic injury. Among the molecular pathways implicated in these...

Tumor-associated neutrophil (TAN) enrichment is a defining feature and driving force of brain metastases (BrMs), a leading cause of death in solid tumors. Yet, the mechanisms governing TAN enrichment in BrM remains undefined. Herein, we demonstrate that BrM cell-derived shed soluble mesothelin (sMSLN) critically prolongs neutrophil survival to facilitate tumor cell colonization and outgrowth in the brain. Specifically, sMSLN binds to toll-like receptor 4 (TLR4) on neutrophil to activate the...

Zoonotic viruses originating from mammals pose a persistent threat to global health. While rodents and bats are often considered "special reservoirs," it is debated if spillover risk is driven by specific taxa or merely reflects mammalian species richness. However, most tests have focused on published host-virus association datasets, which can reflect systematic biases in host and virus sampling effort. To address this limitation, we analyzed a comprehensive repository of 4,685 metagenomic...

CONCLUSION: Individuals with cognitive profiles consistent with probable executive MCI were identified using simple assessments of global cognition, memory and executive functions in a community-dwelling older population. As participants were not clinically diagnosed, further prospective studies are needed to determine the screening performance of this approach.

CONCLUSION: Episodic memory practice effects appear to carry meaningful information beyond generic retest-related gains. Explicitly modeling retest effects while preserving interindividual differences in practice-related improvement may refine the characterization of longitudinal cognitive trajectories and help identify subtle early differences in cognitive resilience and vulnerability.

Despite progress on noble-metal high-entropy alloy catalysts, noble-metal-free high-entropy alloy catalysts continue to face limitations in activity and stability. Atomic defect engineering holds promise for unlocking catalytic potential, yet efficient strategies for designing defects to simultaneously tailor electronic structures and enhance catalytic active sites in noble-metal-free high-entropy alloys remain challenging. Here, we report a general rule to drive twin formation via precisely...

Diet is associated with biological aging, yet few existing dietary indices have been developed specifically to target biological aging. We develop a data-driven, food-based Empirical Dietary Index for Slower Epigenetic Aging (EDISEA) to identify dietary features predictive of lower GrimAge2 acceleration. Higher EDISEA is associated with 4.17 years slower epigenetic aging in the derivation sample of 1,711 participants (P-value < 0.001) and 3.77 years slower aging in an independent sample of 2,311...

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CONCLUSIONS: Serum NfL demonstrated potential as a sensitive and non-invasive biomarker for early detection and staging of cognitive decline. The establishment of population-specific cut-offs within an Indian cohort contributes to global efforts toward standardizing blood-based biomarkers for AD.

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In our systematic review and meta-analysis, we aimed to assess the predictive accuracy and clinical applicability of ten dementia risk assessment scores for incident dementia in cohort studies. Three of 10 risk scores had sufficient, comparable data for a meta-analysis. We analyzed the Cardiovascular Risk Factors Ageing and Dementia (CAIDE), Lifestyle for brain health (LIBRA), and Alzheimer's Disease Risk Index (ANU-ADRI) in middle- and older-aged baseline populations with short, medium, and...

Aerobic exercise attenuates age-related physiological decline, potentially through favorable modulation of gut microbiota diversity. The purpose of this study was to characterize aerobic exercise training (ET)-induced alterations in the gut microbiome of aging, genetically heterogeneous UM-HET3 mice and examine associations between microbial shifts and changes in body composition (body weight, lean mass, and fat mass) and exercise capacity (total work, distance, and duration). Male UM-HET3 mice...

CONCLUSIONS: These findings provide a valuable reference for cost-effectiveness studies on interventions for older adults, enabling policymakers to assess the economic viability of allocating healthcare resources to this population. Furthermore, policymakers can consider the reasons behind older adults' reluctance to invest in longer, healthier lives, which could inform targeted strategies to encourage greater investment in their health.

Proteomic ageing clocks are emerging tools that estimate biological age from protein abundance patterns. Most models are developed using blood capturing inflammatory, metabolic, and extracellular proteins, including secreted signalling factors. Large-scale plasma studies now predict chronological age, disease risk and mortality, but muscle-related models remain indirect, relying on organ-enriched circulating proteins rather than biopsy-derived skeletal muscle clocks. We review current proteomic...