Aging & Longevity

Age-related breakdown of the blood-brain barrier (BBB) is associated with cerebrovascular and neurodegenerative diseases, yet its underlying mechanisms remain unclear. Here, we find that BBB leakage begins in midlife and is driven primarily by increased endothelial caveolar transcytosis rather than tight junction disruption. AAV-mediated knockdown of caveolin-1 or restoration of Mfsd2a expression reduces endothelial vesicle formation and BBB leakage in aged mice. Transforming growth factor...

Conventional BMI-based classifications, even when combined with traditional cardiometabolic risk factors, limit precision in aging-related risk assessment. Here, we perform metabolomic analysis in 13,202 older adults from the natural aging cohort (NCT04517513). Leveraging a panel of 39 core metabolites, we develop accurate and interpretable machine learning models to identify metabolic dysfunction across different BMI categories, achieving area under the receiver operating characteristic curve...

CONCLUSION: Higher TyG-related metabolic indices were associated with incident PE in this large prospective cohort. PhenoAgeAccel-related decomposition and genetic susceptibility analyses were exploratory and require external replication.

CONCLUSION: This study provides insights about the potential of simultaneous motor-cognitive training for improving motor capacities in older adults, even if its efficiency is not different to motor training. Furthermore, neither incorporated nor additional training seem to be the optimal modality. Future comparative studies are needed to draw firm conclusions.

Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D + Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying multi-level systemic mechanisms in the aging kidney remain poorly defined. Here, we systematically evaluated the long-term effects of D + Q in naturally aged mice using multi-omics approaches. We show...

Age-related decline in left ventricular (LV) diastolic function is a hallmark of cardiac aging and an early precursor to cardiovascular disease. While dyslipidemia is a known driver of coronary heart disease (CHD), the molecular pathways linking lipid metabolism to cardiac aging and subsequent CHD risk remain poorly understood. Furthermore, longitudinal lipidomic profiling of cardiac aging in large human populations has not been systematically conducted. Using an untargeted LC-MS, we repeatedly...

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Aging is intimately entangled with the reprogramming of metabolic pathways that coordinate energy production, biosynthesis, and molecular turnover. However, visualizing and understanding these metabolic underpinnings within their spatial and temporal contexts remains a major challenge. Metabolic imaging has emerged as a transformative approach that enables spatially resolved visualization of metabolic dynamics both at the molecular or cellular and organismal levels. In this review, we summarize...

Lateralization is a hallmark of brain organization, yet the structural basis underlying this phenomenon remains a critical, unresolved question in cognitive and systems neuroscience. In this study, we applied multivariate machine learning techniques to investigate variations of global brain asymmetry and their associations with cognitive functions, aging, and aging-related diseases, using large-scale datasets. Our findings revealed substantial and previously unknown structural differences...

The self-assembled monolayer (SAM) has driven the rapid increase in the power conversion efficiency (PCE) of perovskite solar cells (PSCs). However, the operation stability of these PSCs under real conditions continues to be challenging. We developed an SAM based on phthalocyanine, which has a structurally robust framework with chemically stable bonds that enhance photostability. Tetraphosphorylation further enables the firmly locked phthalocyanine at the interface, which improves thermal...

Telomeres progressively shorten and accumulate damage with aging, and this contributes to cellular senescence and hematopoietic dysfunction. We previously showed that telomere dysfunction induces synthesis of telomeric noncoding RNAs required for activation of the telomeric DNA damage response (tDDR), a driver of senescence and inflammation. However, whether the tDDR causally impairs hematopoiesis remained unclear. Here we show in telomerase-deficient Terc^(-/-) mice, which recapitulate...

CONCLUSIONS: These findings provide novel evidence for the interactive effects of objective and subjective age, psychosocial resources, and cultural context on cognitive aging, highlighting the potential importance of age perceptions and social participation in cognitive aging.

CONCLUSIONS: The findings of this study demonstrate that adequate sleep duration and PA are crucial independent and synergistic protective factors against rapid frailty progression. These findings highlight that concurrently targeting both behaviors is a vital clinical strategy to mitigate severe frailty and promote healthy aging.

CONCLUSIONS: This study highlights the importance of multidimensional health profiles in understanding cognitive vulnerability among older adults. The identified patterns of co-occurring physical and psychosocial symptoms highlight the importance of adopting holistic, tailored strategies to support cognitive health. Developing profile-specific interventions addressing physical function, symptom management, and psychosocial well-being is essential for preventing cognitive decline in this...

CONCLUSION: Home rehabilitation comprises three main intervention approaches. The Activity-based and Exercise-based yield small improvements in BADL and physical performance. Evidence for other ADL outcomes and the Reablement-based remains limited.

INTRODUCTION: Aging is associated with reduced accuracy in recognizing others' emotions, an ability that is important for maintaining social connectedness in later life. Laughter is a social signal with multiple functions, as it can facilitate social bonding but also convey negative social meanings, for example when directed at someone. In previous research we have shown that younger adults are able to classify spontaneously emitted joyful, schadenfreude, and tickling laughter above chance...

CONCLUSION: Conclusion: Fallers presented more depressive symptoms, morbidities, polypharmacy, and worse subjective health status. Depressive symptoms do not act directly over the number of falls; nonetheless, those with depressive symptoms presented a higher chance of falling, which may be associated to slower reaction time. Psychological symptoms play an important role in falls, and should, therefore, be considered in identifying older people at risk and in developing prevention programs.

BACKGROUND: Rapid population ageing presents one of the defining global health challenges of the twenty-first century. While digital technologies are increasingly used to support older adults, their deployment often remains fragmented, inequitable, and insufficiently guided by ethical and legal frameworks. This paper proposes an integrated policy agenda for healthy longevity, based on the interdisciplinary work of the Einstein Circle Longevity - Healthy Ageing Assisted by Digital Technologies.

With global population aging, sarcopenia and osteoporosis have become critical public health challenges. Muscles and bones are closely interconnected anatomically and functionally, but the biological mechanisms connecting sarcopenia and osteoporosis have not yet been fully elucidated. This study systematically investigated the bidirectional relationship and shared mechanisms between sarcopenia and osteoporosis through multi-omics analysis integrating genomic, proteomic, and metabolomic data from...

KLHL14, a component of an E3-ubiquitin ligase complex, has emerged as a context-dependent oncogene or tumor suppressor, particularly important for thyroid development. Yet its role in thyroid biology remains largely unexplored. In this study, we uncover a central function for KLHL14 in maintaining thyroid epithelial identity and regulating tissue homeostasis. Using a thyroid organoid model, we show that KLHL14 is essential for the proper growth and maturation of thyroid cells. Reduction of...