Aging & Longevity

SomaMutDB 2.0: A comprehensive database for exploring somatic mutations and their functional impact in normal human tissues

20 hours 20 minutes ago
Recent advances in ultra-accurate sequencing technologies have revealed that somatic mutations accumulate throughout the human lifespan and may contribute to both normal aging and disease. These mutations are highly diverse, often non-recurrent, and functionally heterogeneous, making their biological impact difficult to evaluate systematically. Although many studies have profiled somatic mutations in individual tissues or limited cohorts, a centralized and scalable platform that integrates...
Anthony Shea

Protein kinase Cι dictates tumor trajectory, cell plasticity, and immune surveillance in lung adenocarcinoma

20 hours 20 minutes ago
Lung adenocarcinoma (LUAD), the most prevalent form of lung cancer, is characterized by aggressive growth, immune resistance, and high tumor heterogeneity. Here, we demonstrate that genetic loss of protein kinase Cι (PKCι), which is found in ∼20% of LUAD patients, alters the trajectory of mouse Kras/Trp53-driven LUAD tumors from one resembling lung development to one mimicking lung regeneration. As a result, a major subset of tumor cells with PKCι loss exhibit cellular senescence and...
Duy T Nguyen

<em>Schizosaccharomyces pombe</em> Telomerase RNA: Secondary Structure and Flexible-Scaffold Function

20 hours 20 minutes ago
The telomerase RNA-protein enzyme is critical for most eukaryotes to complete genome copying by extending chromosome ends, thus solving the end-replication problem and postponing senescence. Despite the importance of the fission yeast Schizosaccharomyces pombe to biomedical research, very little is known about the structure of its 1212 nt telomerase RNA. We have determined the secondary structure of this large RNA, TER1, based on phylogenetics and bioinformatic modeling, as well as genetic and...
Karen McMurdie

Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity

20 hours 20 minutes ago
Synapses must be resilient to the challenges they confront during development, experience, disease, and aging. A conserved form of adaptive plasticity, observed at the glutamatergic Drosophila neuromuscular junction (NMJ), is expressed following acute pharmacological blockade of postsynaptic glutamate receptors (GluRs). This challenge is counteracted by enhanced presynaptic neurotransmitter release to maintain stable synaptic strength. This retrograde form of homeostatic plasticity is termed...
Chengjie Qiu

Gender Gap in Cancer-Free Life Expectancy in the United States: The Association With Smoking, Poor Diet, and Physical Inactivity

20 hours 20 minutes ago
BackgroundWhile life expectancy has increased globally, chronic disease burdens remain high. Cancer, despite improved survival, remains a major cause of disability and the second leading cause of death. Though behavioral risks such as smoking, poor diet, and physical inactivity are linked to cancer, few studies examine their impact on cancer-free life expectancy and gender disparities.MethodsUsing U.S. Health and Retirement Study data (2004-2020) and a multistate model approach, we estimated...
Alessandro Feraldi

Examination of the healthy aging center data

20 hours 20 minutes ago
CONCLUSION: Frailty, malnutrition, cognitive impairment, and depressive symptoms were frequent among community-dwelling very old adults, particularly women. These cross-sectional findings emphasize the need for multidisciplinary and gender-sensitive strategies within HACs to support functional independence and mental well-being. Longitudinal and multivariate studies are warranted to confirm these associations.
Yasin Altun

Defining successful program configurations in VA home-based primary care: a study protocol to identify key difference-makers through investigating cross-case heterogeneity in program implementation

20 hours 20 minutes ago
BACKGROUND: The Department of Veterans Affairs (VA) is the largest integrated healthcare system in the United States and serves a rapidly aging patient population. The VA's Home-Based Primary Care (HBPC) program is a home care model for older, complex, high-risk Veterans that provides comprehensive, longitudinal primary care delivered by an interdisciplinary team of VA staff, with plans for expansion by 2027. HBPC program implementation varies considerably across local sites and contexts....
Anaïs Tuepker

Association between spouse health and cognitive function in older Chinese adults: a moderated mediation of frailty and activity engagement

20 hours 20 minutes ago
CONCLUSION: This study shows a significant association between spousal health and cognitive function among older adults, with frailty serving as a fully mediator in this association. Crucially, activity engagement is associated with a weaker impact of frailty on cognitive abilities, with greater involvement linked to less pronounced cognitive decline. These findings emphasize the dual protective roles of a spouse's health and activity engagement in sustaining cognitive health.
Junhao Huo

Translation, cultural adaptation, and Turkish validation of the tool 25-question geriatric locomotive function scale

20 hours 20 minutes ago
CONCLUSIONS: The Turkish adaptation of GLFS-25 is a valid, reliable, and culturally appropriate tool for assessing locomotive dysfunction in Turkish older adults. Its strong psychometric properties and high correlation with functional mobility indicators suggest that it can be effectively integrated into geriatric healthcare and rehabilitation programs. Given the rapid aging of Turkey's population, this tool can support early detection, prevention strategies, and policy development to mitigate...
Esedullah Akaras

The prevalence and associated factors of perceived physical and mental fatigability among older adults in regional China

20 hours 20 minutes ago
CONCLUSIONS: Perceived fatigability is prevalent among older adults and exhibits strong associations with age, educational level, alcohol drinking, PA, depressive and anxiety symptoms, and sleep quality in regional China. These findings suggested that fatigability is a public health problem among older adults in China and particular attention should be paid to burden caused by fatigability and its associated factors.
Qing Ye

Swedish centenarian health - a nationwide, observational study on care utilization, drug use, morbidity, and mortality among Swedish centenarians in 1990 to 2022

20 hours 20 minutes ago
CONCLUSION: Overall, the data suggest that the health status of Swedish centenarians has worsened over time. Although some of these changes may reflect improved diagnostics and increased drug prescriptions, it is likely that morbidity has also risen as a result of greater survival from disease at older ages.
Jimmy Lindberg

Impact of free health check-ups on elderly healthcare utilization and health: a pooled cross-sectional study

20 hours 20 minutes ago
CONCLUSION: The free health check-up program for the elderly was associated with a reduction in their medical use and an increase in their health, positioning it as a potential model for other countries grappling with an ageing populace. Despite free nature of the program, the increment in the health check-up utilization remains low among the elderly. Enhanced efforts to promote effective use and follow-up consultation are necessary.
Shiju Dong

Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells

1 day 20 hours ago
Aging impairs hematopoietic stem cells (HSCs), driving clonal hematopoiesis, myeloid malignancies, and immune decline. The role of lysosomes in HSC aging-beyond their passive mediation of autophagy-is unclear. We show that lysosomes in aged HSCs are hyperacidic, depleted, damaged, and aberrantly activated. Single-cell transcriptomics and functional analyses reveal that suppression of hyperactivated lysosomes using a vacuolar ATPase (v-ATPase) inhibitor restores lysosomal integrity and metabolic...
Tasleem Arif

Space-associated stem cell hallmarks of aging and resilience in astronauts

1 day 20 hours ago
Previous reports revealed immune dysfunction, chromosomal abnormalities, cytokine deregulation, and telomere alterations after prolonged spaceflight. However, the stress of space on hematopoietic stem and progenitor cells (HSPCs) and the resilience properties maintaining lifelong hematopoiesis and immunity were not studied. We performed HSPC functionally organized multi-omics aging and resilience (HSPC-FOMA-R) analyses in 9 astronauts before, during, and after three short-duration International...
Jessica Pham

Recycling of ribosomes at stop codons drives the rate of translation and the transition from proliferation to RESt

1 day 20 hours ago
Translation is made of initiation, elongation, and termination. The role of termination in relaying extracellular outputs to the translation machinery is unknown. We show, in mice, that the controlled recycling of ribosomes post-termination is a major checkpoint that integrates mitogenic signals and antiviral responses. In detail, the recycling of ribosomes at stop codons, maximal translation, and cellular proliferation strictly depend on eIF6 phosphorylation, both in vitro and in vivo. Lack of...
Annarita Miluzio
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4 hours 7 minutes ago
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