Aging & Longevity

Amyloid and tau pathologies are drivers of white matter damage in aging and Alzheimer's disease

12 hours 32 minutes ago
White matter hyperintensities (WMHs) are increasingly recognized as neuroimaging biomarkers of cerebrovascular pathology in Alzheimer's disease (AD), yet their temporal relationship with amyloid and tau accumulation remains unclear. While previous studies suggest bidirectional associations between WMHs and AD pathology, regional associations between WMHs and AD pathology have yet to be examined. This study investigated the temporal and regional associations between PET measures of amyloid (Aβ)...
Farooq Kamal

Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts

12 hours 32 minutes ago
Similarities and differences in the self-assembly of actin filaments from different species inform our understanding of its evolution. However, this basic knowledge is largely incomplete. Here, we systematically characterize assembly kinetics for actin from two yeast species that are five hundred million years apart in evolution, Saccharomyces cerevisiae and Schizosaccharomyces pombe, and compare them to the well-studied rabbit muscle actin from which they diverged a billion years ago. We find...
Ingrid Billault-Chaumartin

Awareness of Age-Related Gains and Losses and Their Associations with Hearing-Related Health Behaviors in Midlife and Older Adulthood

12 hours 32 minutes ago
CONCLUSION: Awareness of age-related losses may be adaptive when it reflects realistic recognition of age-related challenges, like hearing difficulties. Promoting positive, gain-focused views of aging could support earlier informal help-seeking among older adults by encouraging open conversations about hearing concerns within their close social networks.
Jana Koch

Placental nicotinamide adenine dinucleotide modulates the timing of labor

12 hours 32 minutes ago
Labor is mediated proximately by prostaglandin signaling within gestational tissues and must be tightly regulated for birth to occur after appropriate fetal development. Metabolic changes accompanying gestational aging have been postulated as a determinant of birth timing, but specific nutrients, sensors, and messengers remain obscure. We report that placental nicotinamide adenine dinucleotide (NAD^(+)) dynamically tunes gestational length. Depletion of placental NAD^(+) in mice provoked labor...
Erin J Ciampa

Beyond technical access in digital eldercare: how ethical lag shapes stratified responsiveness to institutional welfare in rural China

12 hours 32 minutes ago
CONCLUSIONS: The findings suggest that limited uptake of digital elder care is closely tied to moral legitimacy and ethical recognition. Digital care services are more likely to be accepted when perceived as a supportive extension of, rather than a replacement for, family care responsibilities. Addressing ethical lag through culturally resonant service design and trusted community mediation may help reduce inequalities in engagement and improve the effectiveness of ageing-related service...
Yuhe Liu

A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging

1 day 12 hours ago
A decline in nuclear factor erythroid 2-related factor 2 (NFE2L2)-orchestrated adaptive homeostasis and oxidative distress are thought to be key features of aging. In contracting skeletal muscle, the reactive oxygen species-producing enzyme NADPH oxidase 4 (NOX4) is a potent inducer of NFE2L2 adaptive homeostasis. Here, we report that skeletal muscle NOX4 levels decline in aged mice and humans, resulting in abrogated NFE2L2 adaptive homeostasis, increased protein oxidative damage, and decreased...
Chrysovalantou E Xirouchaki

Oil-impregnated densified wood veneer with high electrical insulation enabled by nanosized oil channels

1 day 12 hours ago
Growing energy demands and renewable integration are stressing the aging power grid infrastructure. Lignocellulosic oil-impregnated paper is widely used in power transformers but suffers from critical limitations, such as low dielectric strength, mechanical strength, and thermal conductivity, causing premature transformer failures. Here, we demonstrate a superior electrically insulating oil-impregnated paper design using the naturally anisotropic structure of densified wood veneer to achieve...
Meiling Wu

Persistent and transient senescent cells contribute to brain-barrier development

1 day 12 hours ago
Establishment of the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier requires precise coordination between diverse cell types to protect and nourish the brain. Here, we identify developmentally programmed p21^(+) senescent cells that exhibit divergent senescence-associated features across these two brain interfaces in mice. In the choroid plexus (ChP), epithelial cells adopt a lifelong, non-inflammatory senescent state associated with CSF production and blood-CSF barrier...
L Ashley Watson

Artificial intelligence across the aging continuum: mechanistic geroscience, therapeutic innovation, and clinical impact

1 day 12 hours ago
Aging emerges from nonlinear interactions among primary, antagonistic, and integrative hallmarks that progressively erode tissue resilience. As global demographics shift and chronic disease burden intensifies, extending healthspan with mechanistic precision has become imperative, accelerating the incorporation of artificial intelligence into geroscience. AI leverages multi-omics, spatial biology, imaging, and clinical data to reveal nonlinear structures linking hallmark interactions to tissue...
Hongbo Li

Cerebral hypoperfusion and the vascular-metabolic-immune-glymphatic network in Alzheimer's disease: mechanisms, diagnosis, and therapy

1 day 12 hours ago
Alzheimer's disease (AD), characterized by progressive cognitive decline, represents a major public health challenge in aging societies. Since the proposal of the amyloid cascade hypothesis, Aβ-targeted therapeutic strategies have dominated this field for over three decades. Although recent anti-Aβ antibodies have shown modest promise, their limited clinical benefits coupled with safety concerns underscore the necessity of re-evaluating the pathological mechanisms underlying AD. Cerebral...
Mingyuan Yao

Deficiency of G9a boosts muscle regeneration through IL13/Musclin-mediated crosstalk between macrophage and myofiber

1 day 12 hours ago
Muscle regenerative capacity declines with aging and disease, which leads to muscle loss and reduced lifespan. Muscle regenerative failure is related to a disrupted network orchestrated by multiple muscle-harbored cell types; whether and how the interplay between macrophages and myofibers contributes to this process is largely unknown. Herein, we report upregulation of histone methyltransferase G9a in both aged human muscle and mouse muscle after injury. Deletion of G9a in either myeloid cells...
Ying Jin

Radiation induces senescence in lymphatic endothelial cells (LECs) and murine tail lymphedema tissue, contributing to lymphedema progression

1 day 12 hours ago
Cancer-related lymphedema (CRL) is an incurable disease characterized by progressive swelling of extremities. One of the risk factors in developing CRL is cancer treatments, including surgery and radiation. This leads to damage to the lymphatic system, causing accumulation of interstitial fluid, infiltration of inflammatory cells and cytokine release, tissue remodeling, accumulation of subcutaneous fat, and fibrosis. Radiation therapy (RT) inhibits lymphatic proliferation and survival by...
Samaneh Safarpour

Low circulating adropin concentrations identify vulnerability in learning-dependent cognitive performance in aged rhesus macaques

1 day 12 hours ago
Identifying biomarkers that identify vulnerability to age-related cognitive decline is a major priority in aging research. Adropin, a circulating peptide that regulates metabolic and vascular homeostasis, has been associated with cognitive performance in humans, but its relevance across species has remained unclear. Here we report low plasma adropin concentrations associate with poor decision-making in aged rhesus macaques subject to an increasing food choice test paradigm. Animals with higher...
Andrew A Butler

Efficient and durable light-alkane oxidation over sintered Pt catalysts

1 day 12 hours ago
Nanoparticle sintering is typically regarded as a deactivation mechanism for supported metal catalysts, motivating efforts to maximize metal dispersion. Here we demonstrate the opposite trend for platinum catalysts in light-alkane oxidation. Intentionally pre-sintered platinum particles, tens of nanometers in size and supported on thermally stable magnesium aluminate, show higher activity than highly dispersed platinum species for propane oxidation. Theory-guided adsorption calculations suggest...
Xuan Tang

Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life

1 day 12 hours ago
The cerebellum contains most of the brain's neurons and supports many functions, yet how it changes with age remains unclear. Here we used three brain imaging studies spanning 47,000 adults and examined how different parts of the cerebellum age and their relation to cognition. We characterized cerebellar aging using volumetry and the T1-weighted/T2-weighted ratio, and corroborated these findings with quantitative magnetic resonance imaging in an independent sample. We show a spatially...
Federico d'Oleire Uquillas

SIRT7 regulates dosage compensation and safeguards the female X chromosome

1 day 12 hours ago
Sirtuins are deacetylases implicated in stress responses and longevity in mammals^(1,2). Although their differential impact on disease for the two sexes has been noted^(3-7), the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7^(-/-) female mice have decreased fitness throughout their lifespan. Notably, SIRT7 preferentially localizes to the sex chromosomes. In female individuals, SIRT7 loss affects...
Nicolas G Simonet
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