Aging & Longevity

No abstract

Controlling Zinc (Zn) nucleation and subsequent crystal growth are critical for long lifespan aqueous zinc metal batteries. However, the concurrent side reactions and unstable solid-electrolyte interphase (SEI) formations impedes the continuous Zn metal electrodeposition. Herein, induced by a well-designed organic/inorganic dual-phase SEI, we realize ordered zinc electrodeposition of polycrystalline stackings from single-crystal building blocks. The uncommon SEI with appropriate ion transport...

ObjectiveThe objective of this study was to examine the association between religious practices, beliefs, and cognitive impairment among Black and White men with modest incomes in the 2016 Health and Retirement Study.MethodsData were drawn from Black and White men who reported annual incomes at or below $50,000 (n = 926). The primary outcome was any cognitive impairment, a dichotomous variable derived from a modified version of the Telephone Interview for Cognitive Status. The religious...

ObjectiveThis article introduces a special issue on advancing Alzheimer's disease (AD) and AD-related dementias (ADRD) research drawing from research conducted by the Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research (JHAD-RCMAR).MethodWe describe the JHAD-RCMAR, highlighting work of early career investigators in the JHAD-RCMAR, summarize key accomplishments, and propose recommendations for next steps in ameliorating disparities in cognitive decline and AD/ADRD...

The objective of this study was to determine if racial differences exist between older Non-Hispanic Black (NHB) and White (NHW) men in incident dementia over 11 years (2011-2022) in the National Health and Aging Trends Study (NHATS). The analytic sample included 2395 community-dwelling NHB and NHW men free of dementia at baseline who self-identified as Non-Hispanic Black (NHB) and White (NHW). Dementia was assessed at each visit using a validated algorithm developed by NHATS. After adjusting for...

ObjectivesThe objective was to examine racial-ethnic differences in longitudinal engagement for lifestyle behaviors and moderating role of race-ethnicity between lifestyle behaviors and dementia risk.MethodsWe analyzed 2011-2021 National Health and Aging Trends Study data, a nationally representative U.S. sample of 6155 White, Black, Hispanic, and Asian older adults aged 65+. Cox models regressed dementia on the interaction between lifestyle behaviors (physical activity, smoking, and social...

BackgroundSubjective cognitive impairment (SCI), assessed in national surveys, offers potential for dementia monitoring and early detection. However, its causal link to dementia risk remains unclear.ObjectiveTo evaluate whether SCI causally affects dementia risk in U.S. older adults (≥65 years), considering mortality as a competing risk.MethodsUsing data from 1622 dementia-free older adults in the National Health and Aging Trends Study (NHATS) during 2011-2019, we estimated total, direct, and...

Basal forebrain cholinergic neurons (BFCNs) are the sole source of cholinergic innervation to the cerebral cortex and hippocampus in humans and the primary source in rodents. This system undergoes early degeneration in Alzheimer's disease. BFCNs terminal synapses are involved in the regulation of the cerebral blood flow by making classical synaptic contacts with other neurons. Additionally, they are located in proximity to cortical cerebral blood vessels, forming connections with various cell...

In normal aging, little is known in human and animal models about functional changes to glutamate neuronal systems that may contribute to age-related cognitive differences. The present studies investigated glutamate neuronal signaling in the hippocampus (dentate gyrus) and frontal cortex (infralimbic) of young adult (3-8 months), middle-aged (10-13 months), and aged (15-27 months) male and female C57BL/6 mice using microelectrode electrode array (MEA) recording technology to measure...

Partial or transient cellular reprogramming is defined by the limited induction of pluripotency factors without full dedifferentiation of cells to a pluripotent state. Comparing in vitro and in vivo mouse studies, and in vitro studies in humans, supported by visualizations of data interconnections, we show consistent patterns in how such reprogramming modulates key biological processes. Generally, partial reprogramming drives dynamic chromatin remodelling, involving histone modifications that...

Mitochondria, as central regulators of cellular processes such as energy production, apoptosis, and metabolic homeostasis, are essential to cellular function and health. The maintenance of mitochondrial integrity, especially through mitophagy-the selective removal of impaired mitochondria-is crucial for cellular homeostasis. Dysregulation of mitochondrial function, dynamics, and biogenesis is linked to neurodegenerative and metabolic diseases, notably Alzheimer's disease (AD), which is...

As the global human population rapidly ages and diseases of aging become more prevalent, preclinical models of age-related neurodegenerative disorders are increasingly important for identifying early diagnostic biomarkers, monitoring disease progression, and evaluating treatment responsiveness. Rhesus macaques are an ideal species for studies on neurodegeneration due to their phylogenetic relatedness to humans and their complex brain anatomy and physiology. Technological advances in assay...

CONCLUSIONS: These results, highlighting recent increases in female suicides in urban areas and in specific method-specific male suicides both in rural and urban areas, and demonstrating geographical variation across regions, should help guide targeted suicide prevention efforts.

5-hydroxymethylcytosine, also known as the sixth DNA base of the genome, plays an important role in brain aging and neurological disorders such as Alzheimer's disease. However, little is known about its genome-wide distribution and its association with Alzheimer's disease pathology. Here, we report a genome-wide profiling of 5-hydroxymethylcytosine in 1079 autopsied brains (dorsolateral prefrontal cortex) of older individuals and assess its association with multiple measures of Alzheimer's...

Energy management technologies have significant potential to optimize electric vehicle performance and support global energy sustainability. However, despite extensive research, their real-world application remains limited due to reliance on simulations, which often fail to bridge the gap between theory and practice. This study introduces a real-world data-driven energy management framework based on offline reinforcement learning. By leveraging electric vehicle operation data, the proposed...

As China's population continues to age, addressing cognitive decline related to aging has become increasingly important. Simultaneously, rapid economic development has led to rising concerns about lipid metabolism disorders, particularly those involving blood lipids. Identifying modifiable risk factors early is critical to enhancing cognitive function in older adults. Thus, this study focuses on the relationship between triglycerides (TG), high-density lipoprotein (HDL), and cognitive...

Vascular Endothelial Growth Factor (VEGF) is a critical element in vascular dementia (VD) pathogenesis and therapeutic development while remaining strongly influenced by aging processes and cellular aging mechanisms. VEGF's multiple effects comprise neuroprotective functions, its role in vascular development, and its ability to regulate brain blood flow systems, all leading to cognitive preservation. The prefrontal cortex exhibits elevated VEGF gene levels, which directly matches the advancement...

Hematopoietic stem cells (HSCs) ageing is a phenomenon described by reduction in self-renewal capacity, compromised homing, a bias towards myeloid differentiation, and defective reconstitution function. The molecular mechanisms of HSCs ageing have been investigated by several groups. In a broad classification, the underlying causes can be grouped into the intrinsic factors and those related to the microenvironment. Determination of the exact mechanism of HSCs ageing and detailed molecular events...

Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previous studies have demonstrated that dysfunctional meningeal lymphatics evoke behavioral changes, but the neural mechanisms underlying these changes have remained elusive. Here, we show that prolonged impairment of meningeal lymphatics alters the balance of cortical excitatory and inhibitory synaptic inputs, accompanied by deficits in memory tasks....

Chronic stress adversely affects intestinal health, but the specific neural pathways linking the brain to intestinal tissue are not fully understood. Here, we show that chronic stress-induced activation of the central amygdala-dorsal motor nucleus of the vagus (CeA-DMV) pathway accelerates premature aging and impairs the stemness of intestinal stem cells (ISCs). This pathway influences ISC function independently of the microbiota, the hypothalamic-pituitary-adrenal (HPA) axis, the immune...