Aging & Longevity

Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging

3 weeks 2 days ago
The increasing global prevalence of diabetic nephropathy poses substantial health and economic burdens. Currently, effective anti-fibrotic therapies for managing kidney fibrosis associated with chronic kidney disease are lacking. This study reveals corisin, a microbiota-derived peptide, as a central driver in the progression of diabetic kidney fibrosis. Corisin levels were found to be markedly elevated in the serum of diabetic chronic kidney disease patients relative to healthy controls, with...
Taro Yasuma

Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results

3 weeks 2 days ago
Recent advancements in cancer immunotherapy have improved patient outcomes, yet responses to immunotherapy remain moderate. Immunosenescence has been shown to contribute to the development and progression of various diseases; however, its specific role in solid tumors has not been fully delineated. Here we conducted a phase 2 clinical trial involving 51 patients with cancer undergoing neoadjuvant chemoimmunotherapy and applied single-cell RNA as well as TCR and BCR sequencing on tumor and blood...
Niu Liu

Migration shapes senescence in a long-lived bird

3 weeks 2 days ago
Each year, billions of animals migrate across the globe on diverse spatial and temporal scales. Migration behavior thus plays a fundamental role in the life cycle and Darwinian fitness of many organisms. While the influence of migration on early-life survival and reproduction is well documented, its effects on senescence (aging) in advanced age remain largely unexplored. Using a unique 44-y ring-resighting dataset from a long-lived, partially migratory bird species, the Greater Flamingo...
Hugo Cayuela

Cohort mortality forecasts indicate signs of deceleration in life expectancy gains

3 weeks 2 days ago
The fast-paced improvements in mortality in high-income countries since the early 1900s have led to a sustained increase in life expectancy. However, whether this linear trend will continue or life expectancy gains will decelerate in the near future remains unclear. To answer this question, we apply multiple established and recently developed mortality forecasting methods to estimate cohort life expectancy for individuals born between 1939 and 2000 in 23 high-income countries. Across all...
José Andrade

Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia

3 weeks 2 days ago
NAD + homeostasis is an important determinant of lifespan and may be a key mechanism of caloric restriction (CR) expansion of lifespan. Ketone bodies such as beta-hydroxybutyrate (BHB) that regulate NAD + abundance and NAD + precursors such nicotinamide mononucleotide (NMN), are known to extend life in experimental animals and ameliorate age-related conditions in humans. We tested the hypothesis that chronic BHB and NMN exposure can extend lifespan similarly to the effect of CR treatment in a...
A Catherine Pearson

Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders

3 weeks 2 days ago
Aging and neurodegenerative diseases are characterized by cognitive decline, impaired neuroplasticity, and epigenetic dysregulation. Curcumin, a bioactive polyphenol derived from Curcuma longa, has gained significant attention for its neuroprotective properties, particularly in enhancing cognitive function through epigenetic mechanisms. This review explores the multifaceted role of curcumin in modulating key molecular pathways involved in neuroplasticity, including histone modifications, DNA...
Hao Jiao

Age-associated trajectories of hippocampus subregion volumes from childhood through later adulthood

3 weeks 3 days ago
The hippocampus has been widely implicated in the neurobiology of neurologic and psychiatric disorders. This structure is heterogeneous, however, and comprised of multiple subregions that have different connectivity patterns and functions. Better understanding how these subregions are affected by age and their relationship with neurocognition could provide information regarding how alterations in normal trajectories play a role in disease and cognitive dysfunction. Using natural splines we...
Suril Gohel

Personalized cognitive enhancement for older adults: An aging-friendly closed-loop human-machine interface framework

3 weeks 3 days ago
Emerging digitally delivered non-pharmacological interventions (dNPIs) offer scalable, low-risk solutions for enhancing cognitive function in older adults, yet their effectiveness remains inconsistent due to a lack of personalization and precise mechanisms of action. Generic, population-based designs often fail to predict individual gains, underscoring the need for more tailored approaches. To address this, we propose a closed-loop human-machine interface (HMI) framework for personalizing dNPIs...
Sa Zhou

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

3 weeks 3 days ago
Cellular senescence restrains the expansion of neoplastic cells through several layers of regulation. We report that the histone H3-specific demethylase KDM4 is expressed as human stromal cells undergo senescence. In clinical oncology, upregulated KDM4 and diminished H3K9/H3K36 methylation correlate with poorer survival of patients with prostate cancer after chemotherapy. Global chromatin accessibility mapping via assay for transposase-accessible chromatin with high-throughput sequencing, and...
Boyi Zhang

Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome

3 weeks 3 days ago
Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process remains limited. Here, we describe alterations in the landscape of the 3D chromatin interactome upon aging, utilizing the low-input promoter capture Hi-C (liCHi-C) technique with mouse hippocampal neurons. We also integrated liCHi-C data with RNA sequencing (RNA-seq) data...
Javier Gancedo-Verdejo

Aging and liver health: liver chemistries and associated factors in community-dwelling older adults

3 weeks 3 days ago
CONCLUSIONS: Liver chemistries in community-dwelling older adults with normal nutritional status were within the normal reference range used for adults. There were small but statistically significant differences with age, sex, and intensity of statin therapy. ALT declined with age, and further prospective studies are required to determine cut-offs for increased risk of adverse clinical outcomes.
Farah Safdar Husain

Cobalt-based catalyst for ammonia synthesis under ambient conditions via transient confinement

3 weeks 4 days ago
The Haber-Bosch process is used for industrial ammonia production worldwide, and it accounts for ~2% of the global energy consumption and 1.3% anthropogenic carbon footprint. Ammonia synthesis under ambient conditions with minimum carbon emission is highly desired, but it is still in the initial stage. Herein, we report a cobalt-based catalyst for ammonia continuous synthesis under ambient conditions via mechanochemistry. To describe mechanochemistry of ammonia synthesis, density functional...
Keran Lv

Association between age and malnutrition in oldest-old and centenarian populations

3 weeks 4 days ago
CONCLUSIONS: This study demonstrated a linear association between age and malnutrition in Chinese oldest-old populations and indicated interaction effects of cigarette smoking, red meat consumption, and vegetable consumption on malnutrition. Food consumption is related to nutritional status as a key element in age-malnutrition association. An in-depth understanding of food and nutrition in older adults could help establish evidence-based recommendations to increase survival rate.
Qiao Zhu

Jingfang granule extends lifespan and healthspan in Caenorhabditis elegans: insights from RNA-seq analysis of genetic mechanisms

3 weeks 4 days ago
Traditional Chinese Medicine (TCM), as a globally recognized phytomedicinal approach, has made significant contributions to healthcare and anti-aging research worldwide. Jingfang Granule (JFG), an established TCM preparation in China, was demonstrated to exert effects on prolonging lifespan and healthspan via the Caenorhabditis elegans model in this study. We employed RNA-seq analysis to investigate the complex genetic interactions through which JFG extends the lifespan of C. elegans. We...
Taili Zhao

Role of branched chain amino acid metabolism on aging

3 weeks 4 days ago
Aging is a complex biochemical phenomenon that considerably impacts both individual health and societal dynamics. Recent researches have emphasized the essential function of metabolism in the processes of aging and longevity. Metabolites-chemical byproducts produced by the host organism and its symbiotic partners, including the microbiota, are generated through numerous metabolic pathways. In the last fifteen years, major progress has been made in elucidating the metabolism of BCAAs and the...
Zhaojia Wang

Ageing well in the urban environment: meeting the health and social needs of older Adults - study protocol for a prospective, longitudinal mixed-methods study

3 weeks 4 days ago
BACKGROUND: Urbanisation and ageing populations are global challenges for ageing well. This mixed-methods study examines the health and social needs of older adults in urban areas in Berlin, Germany and in Singapore, focusing on three key dimensions of healthy ageing and wellbeing: health, mobility, loneliness, and equity as a cross-cutting theme.
Marie Bolster

Unraveling lymphoma-induced immune senescence

3 weeks 5 days ago
B cell lymphomas arise from mutations that disrupt normal germinal center B cell programs and promote a microenvironment that fosters aberrant proliferation and immune escape. In this issue of Cancer Cell, Hesterberg et al. show that lymphoma accelerates T cell aging by transcriptional and epigenetic reprogramming that mirrors physiological aging.
Patrizia Mondello
Checked
4 hours 2 minutes ago
Aging and Longevity: Latest results from PubMed
Subscribe to Aging & Longevity feed