Aging & Longevity

CONCLUSIONS: CPIC Level A pharmacogenetic biomarkers are prevalent in Chinese older adults, with over 40% exposed to actionable gene-drug pairs and 36.5% requiring dose adjustments. These findings highlight the clinical imperative to integrate pharmacogenetic testing into geriatric care, prioritize CYP2C19 and SLCO1B1 testing, and develop region-specific guidelines to mitigate polypharmacy risks. Policymakers and clinicians should consider targeted implementation strategies to optimize...

The concept of resilience can be used to explain why there are differences in the degree to which the brain functions of different individuals are impaired due to aging and pathological factors associated with neurodegenerative diseases. It encompasses cognitive reserve, brain reserve, and brain maintenance. Long-term research has identified a default mode network (DMN) related to cognitive reserve. This mode can modulate the negative impact of Alzheimer's disease (AD) pathological burden on...

In the context of increasing life expectancy, a higher prevalence of age-related chronic diseases is becoming more common in the health landscape, many of which are closely linked to insufficient physical exercise during lifespan. On the other hand, aging is also associated with damage to various molecules, including DNA, by reactive oxygen species. Given that both senescence and muscle mass loss are intimately linked to increased levels of DNA damage and deterioration of antioxidant defense,...

CONCLUSIONS: Our findings provided a novel global perspective on the temporal trends of PAH burden in the elderly population, augmenting the existing evidence and understanding of PAH epidemiology in this demographic. Additionally, these results identify gaps in various aspects of prevention, management, and intervention strategies for PAH in the elderly.

Aging represents a major risk for human neurodegenerative disorders, such as dementia and Alzheimer's disease, and is associated with a functional decline in neurons and impaired synaptic plasticity, leading to a gradual decline in memory. Previous research has identified molecular and functional changes associated with aging through transcriptomic studies and neuronal excitability measurements, while the role of chromatin-level regulation in vulnerability to aging-related diseases is not well...

CONCLUSION: Findings suggest the need for targeted interventions that take into account sociodemographic and psychological factors to support the safe use of medications in aging societies.

CONCLUSIONS: This study underscores the need for ACPbp in RACFs, provides guidelines for such programs and identifies the specific aspects necessary for the development of ACPbp programs in this context.

CONCLUSION: This study revealed that anemia is prevalent among individuals aged ≥ 60 years in China and is related to age, residence type, hypoproliferation, hematocrit, total cholesterol and the creatinine clearance rate. Research has also confirmed that anemia is associated with worse overall survival in Chinese older adults.

Fibroblasts, critical for skin structure and function via extracellular matrix (ECM) production, undergo senescence linked to ECM changes and inflammation via senescence-associated secretory phenotypes (SASPs). Transforming growth factor (TGF-β), a pleiotropic cytokine, modulates fibroblast function through multiple signaling pathways, inducing cell cycle arrest, oxidative stress, DNA damage, and SASP production. These processes disrupt ECM homeostasis, exacerbate inflammation, and impair tissue...

Circadian time keeping system (CTS) consisting of network of central and peripheral clocks regulates physiological, metabolic, and behavioural processes in alignment with the 24 hour. Desynchrony between central and peripheral clocks contributes to the pathogenesis of age-related conditions such as metabolic syndrome, cognitive decline, immune dysfunction, and neurodegenerative diseases etc. Sex-specific susceptibilities further modulate circadian resilience, with hormonal changes and redox...

CONCLUSIONS: The 6-month Exernet-Elder 3.0 training programme demonstrated an ICER of €115 per SPPB point gained, €407 per point of frailty reduction, and €6274 per QALY gained. The intervention was low-cost (€164 per participant) and produced clinically meaningful improvements in functional capacity, HRQoL, and frailty. These findings underscore the importance of integrating a structured, group-based exercise programmes into public health strategies to address the growing socioeconomic and...

Lung cancer is a leading cause of cancer-related mortality worldwide and is predominantly diagnosed in older adults, underscoring the need to explore aging-related biological mechanisms that influence disease progression and prognosis. Cellular senescence, a hallmark of aging, plays a dual role in cancer by contributing to both tumor suppression and tumor promotion through its influence on tumor growth, modulation of the tumor microenvironment, the senescence-associated secretory phenotype...

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CONCLUSION: Active social interaction, regular participation in leisure activities, organized social activities, and informal social interactions are associated with more favourable health outcomes among older adults. Policies should prioritize supportive environments and age-friendly community renovations, while families and society should strengthen internal and external support systems to help foster active and healthy aging.

CONCLUSIONS: The receipt of financial support is greater among older adults with basic and instrumental functional disabilities. The association identified highlights the importance of public policies aimed at improving socioeconomic conditions and quality of life for older adults.

CONCLUSION: Low FA levels are strongly associated with increased risks of both objective and subjective negative outcomes. These findings highlight the importance of simultaneously considering IC and environment to properly explore FA in healthy aging.

CONCLUSION: An inverse linear association is observed between SWB and CVD risk among Chinese older adults. The strength of the association was greater in subgroups with more healthy lifestyles than that with less healthy lifestyles. Enhancing SWB and fostering more healthy lifestyle behaviors among older adults contributed to the prevention of CVD.

CONCLUSIONS: Participants described receiving care that was often not person- and family-centered despite this being a purported healthcare system value in Ontario, Canada. A cultural shift is thus needed in medical and social expectations of what it means to care for older adults.

CONCLUSION: Older adults with coexisting diabetes and heart disease experience accelerated declines in gait speed and hand grip strength compared with those with either condition alone or neither. These findings highlight the need for targeted functional monitoring and preventive interventions in this high-risk population, with particular attention given to sex, perceived health, and race-related disparities in physical aging.

CONCLUSION: This study revealed that ADL disability may partially mediate the relationship between depressive symptoms and cognitive function in older adults. Furthermore, the mediating effect of ADL disability was moderated by gender, and the effect was observed exclusively in males when analyzed hierarchically.