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NK2R control of energy expenditure and feeding to treat metabolic diseases
Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1
Mapping the ionosphere with millions of phones
Task-agnostic exoskeleton control via biological joint moment estimation
Observation of Hilbert space fragmentation and fractonic excitations in 2D
Prefrontal transthalamic uncertainty processing drives flexible switching
Foundation models for fast, label-free detection of glioma infiltration
Clinical functional proteomics of intercellular signalling in pancreatic cancer
Fluorspar to fluorochemicals upon low-temperature activation in water
Photochemical permutation of thiazoles, isothiazoles and other azoles
Clearance of <i>p21</i> highly expressing senescent cells accelerates cutaneous wound healing
Thixotropic world
How AI is reshaping science and society
Postdocs count the cost of living in Ireland’s capital
Can AI review the scientific literature — and figure out what it all means?
Canada should sharply curtail research collaborations with China, lawmakers say
Report recommends an immediate ban on joint projects in a host of sensitive fields
First known double gravitational lens could shed light on universe’s expansion
Zigzagging light bent by perfectly aligned galaxies could improve estimates of Hubble constant
Satellite images reveal massive crop losses in war-torn Ukraine
As Russia’s invasion creeps inward, farmers are abandoning millions of hectares of farmland
A glowing, deep-diving sea slug mystified scientists. Now, it has a name
“Deep deceiver” adds a new branch to the nudibranch family tree
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the relevance of ApoE-associated lipids remain elusive. Here, we report that impaired low-density lipoprotein (LDL) receptor (LDLR) binding of lipidated ApoE2 (lipApoE2) avoids LDLR recycling defects observed with lipApoE3/E4 and decreases the uptake of cholesteryl esters (CEs), which are lipids linked to neurodegeneration. In...