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Background: Cognitive decline poses a significant challenge to healthy aging. While exercise is widely recognized for its cognitive benefits, the comparative efficacy of different exercise modalities and optimal intervention protocols for specific cognitive domains in older adults remains unclear. Objective: This network meta-analysis aimed to systematically compare the effects of five exercise modalities-resistance training, aerobic exercise, mind-body exercise, multicomponent exercise, and...

CONCLUSIONS: Among community-dwellers in six LMICs, DAO was significantly associated with MCI among middle-aged individuals, but not among older people. However, it is important to note that the study was cross-sectional in nature, and thus, it is not known whether DAO leads to MCI or vice versa. Therefore, future longitudinal studies are necessary to clarify temporal associations and possible causality.

Ultra-processed foods (UPF) are increasingly linked to negative health outcomes, including chronic diseases and mortality. Recent evidence suggests that UPF may accelerate biological ageing, potentially explaining their harmful effects. Therefore, this study was aimed to investigate associations between UPF intake categories and mortality risk, examining biological ageing's mediating and modifying effects. We used a prospective cohort design including 172,225 participants in the UK Biobank who...

Vascularized composite allotransplantation (VCA) has emerged as a novel therapy approach to restore form and function in patients with severe tissue defects of the face, hand, and abdominal wall, among other anatomical regions. The composite allografts comprise different tissues such as skin, muscle, or bone. Clinical data demonstrate promising mid- and long-term outcomes following VCA surgery, but our understanding of the cellular interactions and molecular pathways in VCA surgery is oftentimes...

Obesity and aging are interrelated public health concerns, with growing prevalence, especially as global demographics shift toward an older population. This narrative review explores the mechanisms through which obesity accelerates the aging process, focusing on major aging pathways affected by obesity, including deregulated nutrient sensing, telomeres attrition, epigenetic alterations, mitochondrial dysfunction, stem cell exhaustion, and altered intercellular communication. Evidence suggests...

Epigenetic clocks based on DNA methylation provide robust biomarkers of biological age, yet the mechanistic basis and functional significance of slowing these clocks remain unclear. Progress has been limited by the lack of short-lived, genetically tractable model organisms with functional DNA methylation systems. The jewel wasp, Nasonia vitripennis, offers a unique solution. It combines a functional DNA methylation system with a short lifespan and established tools for experimental manipulation....

Aging is a risk factor for severe COVID-19, characterized by vascular endothelial dysfunction. Although possible susceptibility of vascular endothelial cells (ECs) to SARS-CoV-2 infection has been suggested, the details of entry into cells have not been clarified. Previously, we reported that in an aged mouse model of severe COVID-19, ECs show a massive viral uptake and inflammatory response. Here, we focused on the endocytic capacity of senescent ECs. We found that the senescent ECs showed high...

As memories age, their immediate retrievability decreases albeit, due to ongoing memory consolidation, their future rate of forgetting weakens. Here, we show in two experiments (N = 1.216 participants) that mentally traveling back in time to older memories' temporal context at encoding reverses the two effects and makes the memories similar again to how they were at an earlier point in time. Mental time travel increased both the memories' immediate retrievability and their future rate of...

Funding multiyear grants up front will sharply cut number of investigators receiving awards