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Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging

1 year 3 months ago
Cognitive function in aging is heterogeneous: while some older individuals develop significant impairments and dementia, others remain resilient and retain cognitive function throughout their lifespan. The molecular mechanisms that underlie these divergent cognitive trajectories, however, remain largely unresolved. Here, we utilized a high-resolution home-cage-based cognitive testing paradigm to delineate mechanisms that contribute to age-related cognitive heterogeneity. We cognitively...
Matthew P Baier

In Science Journals

1 year 3 months ago
Science, Volume 387, Issue 6739, Page 1159-1161, March 2025.

Michael Funk, and
Yury Suleymanov,
Sacha Vignieri,
Bianca Lopez,
Jake S. Yeston,
Jesse Smith,
Christiana N. Fogg,
Leslie. K. Ferrarelli,
Stella M. Hurtley,
L. Bryan Ray,
Sarah H. Ross,
Keith T. Smith,
Brent Grocholski, and
Courtney Malo

Imperfect sounds

1 year 3 months ago
Science, Volume 387, Issue 6739, Page 1138-1141, March 2025.

Cathleen O’Grady