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Aging is linked to a higher incidence of gut diseases such as inflammatory bowel disease (IBD), yet the underlying mechanisms remain unclear. We identified an age-related decline in magnesium (Mg) levels specifically in the gut across species, prompting investigation of its role in intestinal health. Functional studies demonstrated that Mg restriction accelerates gut aging in old but not in young mice and aggravates colitis severity. Multi-omics analysis of mouse tissues revealed that dietary Mg...

Cognitive decline during aging may be influenced by peripheral factors, including neuroproteins and pro-inflammatory cytokine levels, body composition, and physical fitness. However, the specific associations between these factors and cognitive performance remain underexplored. A comprehensive assessment, including peripheral cytokine and neuroprotein levels, body composition, physical performance (aerobic fitness and muscle strength), and cognitive function was performed in a cohort of 87 older...

In the absence of telomerase, telomere shortening triggers replicative senescence, a tumor suppressor mechanism that is also associated with oncogenic genomic instability. Yet, the precise mechanism that connects these seemingly opposing forces remains poorly understood. To directly study the complex interplay between senescence, telomere dynamics, and genomic instability, we develop a system in Saccharomyces cerevisiae to generate and track telomeres of precise length in the absence of...

Analysis of Wuhan market map suggests China has not disclosed some of the earliest infections in animals and people

Neolithic seafarers who settled Palau were already a blend of Asian and Papuan peoples

Experiments show the crop can survive in lunar soil—with a lot of help

White House review of agency spending plans for this year is causing delays

Bhashini aims to put the power of AI in the hands of all Indians

Alzheimer's disease (AD), an age-associated neurodegenerative disorder, is characterized by progressive cognitive decline, amyloid-β (Aβ) accumulation (including soluble oligomers and deposited aggregates), lipid dysregulation, and neuroinflammation. Although mutations in the amyloid precursor protein (APP) and accumulation of Aβ42 are established drivers of pathology, the mechanisms connecting oligomeric amyloid toxicity with lipid metabolism and inflammatory responses remain poorly understood....

The brain age gap (BAG) is defined as the difference between brain age estimated from MRI using artificial intelligence and chronological age, and has been proposed as a biomarker reflecting aging and neurodegeneration. However, the association between BAG and dementia-related biomarkers has yielded inconsistent findings in previous studies. Conventional training datasets have primarily been defined based on medical history and MRI findings, which may have included participants with underlying...