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Patterns of Organ-Specific Proteomic Aging in Relation to Lifestyle, Diseases, and Mortality
Aging occurs in a heterogeneous manner across different organs, leading to varying risks of chronic diseases and mortality. Biological age offers a more comprehensive reflection of the aging process and is a stronger predictor of disease risk and lifespan. Recent advances in plasma proteomics have enabled the development of organ-specific aging clocks, revealing the distinct aging trajectories and their clinical implications. We used protein-based aging estimators for 11 organs, applying them to...
H5N1 influenza virus stability and transmission risk in raw milk and cheese
Highly pathogenic avian influenza H5N1 viruses have recently spread to dairy cattle, with high levels of virus detected in milk from affected animals, raising concern about the risk posed by unpasteurized dairy products consumed by humans. Here we evaluated H5N1 virus persistence in raw-milk cheeses (n = 3 per condition) made with milk acidified to pH 6.6, 5.8 and 5.0 before cheese making and validated our findings in raw-milk cheeses (n = 4) inadvertently produced with naturally contaminated...
Psycho-socio-economic factors and cardiorenal multimorbidity in middle to older-aged adults: cross-sectional results from the Canadian Longitudinal Study on Aging
Psycho-socio-economic factors (PSEFs) such as income, education, housing, and social support are known to influence health outcomes, yet their relationship with cardiorenal multimorbidity (CRM) remains poorly understood. This study aimed to estimate the prevalence of CRM and examine its associations with PSEFs in a large, nationally representative Canadian sample. We analyzed baseline data from 19,370 participants (mean age: 60 years; 49.8% men) in the Canadian Longitudinal Study on Aging, a...
Bayesian meta-analysis reveals the mechanistic role of slow oscillation-spindle coupling in sleep-dependent memory consolidation
The active system consolidation theory suggests that information transfer between the hippocampus and cortex during sleep underlies memory consolidation in humans. Neural oscillations during sleep, including the temporal coupling between slow oscillations (SO) and sleep spindles (SP), may play a mechanistic role in memory consolidation. However, differences in analytical approaches and the presence of physiological and behavioral moderators have led to inconsistent conclusions. This...
Burden of multimorbidity and verbal phonemic fluency in cognitively healthy and mildly impaired older adults: findings from a real-world study
CONCLUSIONS: The burden of multimorbidity is associated with impaired verbal phonemic fluency in individuals with normal cognition or MCI. Although further studies are required to confirm it, impaired verbal phonemic fluency may be an early sign of cognitive decline in older adults with multimorbidity, with potential implications for prevention strategies.
12-ethoxy-Marchantin A, a new macrocyclic bis-bibenzyl from Marchantia polymorpha L., exerts anti-aging activity through activating MAPKs-dependent Nrf2/HO-1 signaling pathways
Phytochemicals represent emerging anti-aging therapeutic candidates, with Marchantia polymorpha L. (liverwort) gaining significant attention due to its broad-spectrum pharmacological properties. This plant exhibits remarkable wound-healing and regenerative capabilities, making it a promising candidate for the development of modern anti-aging drugs. In the presented study, 12-ethoxy-Marchantin A (EMA), a new macrocyclic bis-bibenzyl compound, was isolated and identified from M. polymorpha. Using...
The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in <em>C. elegans</em>
Aging depends on genetic and environmental factors, but the specific cell types and mechanisms that coordinate aging of the entire organism are not yet fully understood. Glial cells regulate ionic homeostasis, which is essential for neuronal function and survival. Here, we investigated the role of glial ion channel CLH-1, which is a glial pH regulator, in aging. We found that loss of clh-1 extends life span, improves stress resistance, reduces neuronal damage, and extends health span. These...
Substantially improved efficiency and selectivity of carbon dioxide reduction by superior hydrated electron in microdroplet
The photochemical conversion of CO(2) into valuable fuels faces challenges of low efficiency and poor selectivity. Hydrated electrons (e(aq)^(-)), with their extremely negative reduction potential, are promising CO(2)-reducing agents, yet their short lifetime limits selectivity and high-energy-density product formation. Herein, we show that microdroplet interfaces with strong electric fields (10⁹ volts per meter) substantially extend the lifespan of e(aq)^(-) generated from industrial sulfite...
The Long Shadow of Incarceration: The Association of Incarceration History With Self-Reported Health Among Older Adults
CONCLUSION: Prior incarceration is a social determinant of health for older adults, even those with distant incarceration history, and is strongly associated with current poverty and meeting criteria for disability. Further research is needed to understand the mechanisms of these associations and means to mitigate health harms associated with prior incarceration.