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Phase-transition failure in aged skeletal muscle regeneration
Aged skeletal muscle is impaired at every phase of post-injury repair that has been examined, with myeloid recruitment delayed and skewed in composition, debris degradation lagging behind uptake, and muscle stem cell (MuSC) activation following a conserved trajectory at delayed kinetics. Deficits inside a phase may be differences of degree that a longer window absorbs, whereas the transition between phases offers no comparable slack. Each transition is triggered by a defined switch in signal,...
Fauci speaks out about the pandemic, global health—and his own record
Largely silent for the past year, the beleaguered former NIAID chief defends himself in friendly forum