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Author Correction: Mitochondria-associated condensates maintain mitochondrial homeostasis and promote lifespan
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Comparative evaluation of relative fat mass and body mass index in predicting cardiometabolic multimorbidity in older adults: results from the English Longitudinal Study of Ageing
Relative fat mass (RFM) is a more accurate measure of body fat percentage than body mass index (BMI). However, its association with cardiometabolic multimorbidity (CMM) and its predictive value have not been examined. This study evaluated and compared the associations and predictive utility of RFM and BMI for CMM. We analyzed data from 3,348 adults (mean age 64 years; 45.1% male) in the English Longitudinal Study of Ageing who were free of hypertension, coronary heart disease, diabetes, and...
Methylation patterns associated with TTV load in geriatric hospitalized patients: an exploratory functional analysis
Torque Teno Virus (TTV) is a widespread commensal virus within the human virome, characterized by a high prevalence in human population and an unclear pathogenic role. Over the past three decades, TTV has garnered increasing attention due to its ability to establish lifelong chronic viremia, which intriguingly fluctuates among individuals in relation to immune competence status, with a typical peak after an organ transplantation, followed by a plateau and a slow decrease. The regulatory...
The relationship between socio-economic and demographic factors, quality of life and depression in older women in institutional care in Poland - a cross-sectional study
CONCLUSION: The prevalence of depressive symptoms among older women in institutional care in south-western Poland is moderate. The intensity of these depressive symptoms lowers the overall quality of life of care centre residents, as well as their self-assessment of health, and affects their quality of life in the psychological, social, and environmental domains.
Advancing healthcare allocation and prevention of disability: the role of disease-based predictive model for disability in aging adults
CONCLUSIONS: The disability risk prediction model provided a real-time digital prediction mechanism to identify high-risk groups of disability among elderly adults, serving as a valuable decision-making tool for disability prevention and the allocation of medical care resources. Developing prevention and treatment strategies targeting the chronic diseases identified as significant contributors to disability by the predictive model might lead to more effective prevention of disability in elderly...
Influence of sociodemographic and clinical factors on illness progression and quality of life among older adults in Ibadan, Nigeria
CONCLUSION: Duration of symptoms before the commencement of treatment and illness cognition play a significant role in the quality of life of older adults. It is recommended that caregivers of older adults and clinicians consider these factors to improve illness progression and quality of life among the elderly. Qualitative inquiry suggests the need for increased public awareness and stakeholder involvement in interventions for the elderly.
Promote older adults active travel on neighborhood streets: an observation study in Daokou ancient town in China
BACKGROUND AND OBJECTIVES: Seeking to extend previous research on older adults' active travel, this paper focused on the travel duration and neighborhood streets. With an emphasis on the older adults and streets in ancient towns, empirical data were collected in Daokou Ancient Town in China. The aim is to identify environmental attributes promoting active travel.
Impact of a functional gait training program as a complementary strategy to improve physical function in older adults: a randomized clinical trial
CONCLUSION: Integrating the SSM Fisior^(®) program into physical activity workshops enhances muscle activity and functional performance, in terms of Timed Up and Go Test, muscle strength, functionality and calf circumference, supporting its value in promoting healthy aging.
Frailty associated with nutritional status, functionality, physical activity and socioeconomic level, in older adults in Ecuador, post-pandemic
CONCLUSIONS: Frailty prevalence was high among older adults and was significantly associated with low physical activity and low socioeconomic status. These findings highlight critical challenges for Ecuador's public and private healthcare systems in implementing proactive measures to delay the onset of frailty and improve quality of life in this population.
Protein Catabolites as Blood-Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project
Our understanding of aging has grown through the study of systems biology, including single-cell analysis, proteomics and metabolomics. Studies in lab organisms in controlled environments, while powerful and complex, fall short of capturing the breadth of genetic and environmental variation in nature. Thus, there is now a major effort in geroscience to identify aging biomarkers that might be applied across the diversity of humans and other free-living species. To meet this challenge, the Dog...