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Bound by a handshake
Science, Volume 391, Issue 6789, Page 988-989, March 2026.
Astrocytes engineered to fight Alzheimer’s plaques
Science, Volume 391, Issue 6789, Page 990-991, March 2026.
In Other Journals
Science, Volume 391, Issue 6789, Page 1001-1002, March 2026.
Planting a seed
Science, Volume 391, Issue 6789, Page 1078-1078, March 2026.
An unconventional Rubisco small subunit underpins the CO2-concentrating organelle in land plants
Science, Volume 391, Issue 6789, Page 1070-1075, March 2026.
Escaping bottlenecks: The demographic path to genetic recovery in koalas (Phascolarctos cinereus)
Science, Volume 391, Issue 6789, Page 1010-1014, March 2026.
Multiple chromosomal inversions modulate continuous local adaptation along a steep thermal cline
Science, Volume 391, Issue 6789, Page 1015-1021, March 2026.
Irregular hierarchical-porous polymer for high-performance soft thermoelectrics
Science, Volume 391, Issue 6789, Page 1063-1069, March 2026.
Nanodomain-localized formin gates symbiotic microbial entry in legume and solanaceous plants
Science, Volume 391, Issue 6789, Page 1036-1045, March 2026.
Repeated convergent evolution of bradykinin mimics as defensive toxins
Science, Volume 391, Issue 6789, Page 1046-1052, March 2026.
Task learning increases information redundancy of neural responses in macaque visual cortex
Science, Volume 391, Issue 6789, Page 1029-1035, March 2026.
Science stories for young readers
Science, Volume 391, Issue 6789, Page 978-984, March 2026.
Ferroelectricity in atomic-scale titanium dioxide dielectric films
Science, Volume 392, Issue 6795, Page 280-284, April 2026.
‘Insane’ images depict ant species in stunning 3D
New method for visualizing organisms opens the door for mass digitization efforts
Can a wealthy family change the course of a deadly brain disease?
Inspired by the loss of their mother, they have poured millions into studying a key protein behind frontotemporal dementia. But all has not gone according to plan
New HIV cure approach forces hidden virus into tripping immune sensor
Strategy gains momentum after promising results in cell studies and infected people
Epidemiological principles behind worldwide growth of Parkinson disease - a bathtub analogy
No abstract
Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease
Parkinson's disease (PD) is a prevalent neurodegenerative disorder predominantly affecting individuals over 60. Its motor symptoms stem from the deterioration of dopaminergic neurons within the substantia nigra. Despite aging being a significant risk factor, the specific mechanisms linking aging and PD pathology remain unclear. Leveraging advancements in single-cell genomics, this study utilizes single-nucleus multiome sequencing to capture transcriptomic and epigenetic profiles from 40,125...
Resilience-Based Longevity Medicine: A Multiscale and Dynamic Integrative Framework
Population ageing has widened the gap between lifespan and healthspan, with frailty and functional dependence increasingly shaping late-life outcomes. Yet trajectories in older age remain highly heterogeneous, suggesting that vulnerability is not determined by chronological age alone but by differences in adaptive capacity. This review reframes resilience as a dynamic, multilevel construct linking molecular maintenance, regulation within the immune-endocrine-autonomic "vital systems triad," and...
A glucocorticoid-FAS axis controls immune evasion during metastatic seeding
Metastasis is the major cause of death for patients with triple-negative breast cancer and other solid malignancies. Metastases arise from cancer cells that disseminate from the original tumour, survive systemic immune surveillance and colonize new organs¹. Little is known about how initial disseminated tumour cells (DTCs) overcome anti-tumour immunity after seeding a new organ. Here we use a visible antigen in a model of triple-negative breast cancer with cognate CD8^(+) T cells to study the...