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Functional gradients facilitate tactile sensing in elephant whiskers
Science, Volume 391, Issue 6786, Page 712-718, February 2026.
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Science, Volume 391, Issue 6786, Page 694-699, February 2026.
Disappearance of a massive star in the Andromeda Galaxy due to formation of a black hole
Science, Volume 391, Issue 6786, Page 689-693, February 2026.
Dihydroxyhexanoic acid biosynthesis controls turgor in pathogenic fungi
Science, Volume 391, Issue 6786, Page 700-706, February 2026.
Genomic approaches to accelerate American chestnut restoration
Science, Volume 391, Issue 6786, Page 730-735, February 2026.
Fishing ban halts seven decades of biodiversity decline in the Yangtze River
Science, Volume 391, Issue 6786, Page 719-723, February 2026.
The elusive nature of consciousness
Science, Volume 391, Issue 6786, Page 665-665, February 2026.
Imagining the rich lives of invertebrates
Science, Volume 391, Issue 6786, Page 666-666, February 2026.
A small polymerase ribozyme that can synthesize itself and its complementary strand
Science, Volume 391, Issue 6789, Page 1022-1028, March 2026.
Boosting origin of life theory, RNA comes close to copying itself
Some RNA molecules can create their own mirror images, suggesting similar molecules could have sparked life
A vanishing star births a black hole—without the fireworks
Failed supernova candidate points to a stealthy pathway of stellar collapse
India has big plans to remove silt from rivers, alarming scientists
Dredging and mining sediments increases flood risks and threatens infrastructure, researchers say
Microglia makeover: On-demand control panel revamp
Microglia display remarkable plasticity, with their cellular states evolving in response to developmental stage, regional context, and environmental or pathological stimuli. In this issue of Immunity, Hamagami et al. demonstrate that adaptive reconfiguration of regulatory networks, particularly the dynamics of enhancers, underlies these state transitions. Conserved enhancers link developmental and Alzheimer's-related microglial states, suggesting shared epigenetic frameworks that influence...
Cognitive rejuvenation through partial reprogramming of engram cells
Counteracting cognitive decline is a declared goal of regenerative medicine. Recently, partial cellular reprogramming has emerged as a promising strategy to promote tissue regeneration and restore cellular function, but whether this approach bears fruit when targeted to cell populations underlying cognitive processes remains unknown. Here, we report that partial reprogramming of engram neurons-bona fide memory trace cells-by OSK-mediated gene therapy reversed the expression of senescence- and...
Gut macrophages and Parkinson's disease
No abstract
Capillary blood sampling for detecting biomarkers of Alzheimer's disease
No abstract
Exploratory analyses of clinical outcomes from the BIIB080 phase 1b study in mild Alzheimer's disease
This study conducted exploratory analyses of the effects of BIIB080, a MAPT (microtubule-associated protein tau)-targeting antisense oligonucleotide, in participants with mild Alzheimer's disease. A multicenter, randomized, double-blind, phase 1b trial was conducted as a placebo-controlled, multiple-ascending dose (MAD) study followed by an open-label, long-term extension (LTE). During the MAD study, participants were randomized and received either intrathecal placebo or BIIB080 10 mg (n = 6),...
Shedding light on interventions for brain aging
Immunotherapeutic approaches to brain aging remain largely preclinical and in early translational stages, and they have focused mostly on modulating innate immunity. In this issue of Immunity, Negredo et al. identify T cells bearing exhaustion-like signatures as a hallmark of brain aging and reveal the beneficial effects of an engineered IL-10 variant that functionally uncouples pro- and anti-inflammatory signaling in microglia.
Cognitive rejuvenation through partial reprogramming of engram cells
Counteracting cognitive decline is a declared goal of regenerative medicine. Recently, partial cellular reprogramming has emerged as a promising strategy to promote tissue regeneration and restore cellular function, but whether this approach bears fruit when targeted to cell populations underlying cognitive processes remains unknown. Here, we report that partial reprogramming of engram neurons-bona fide memory trace cells-by OSK-mediated gene therapy reversed the expression of senescence- and...
The moderating role of psychological resilience on brain aging and PTSD in a community sample of South African women
Posttraumatic stress disorder (PTSD) is associated with accelerated biological aging. In general, psychological resilience is related to more normative aging patterns; however, among individuals with PTSD, resilience may be associated with older biological aging. For example, prior work suggests that individuals with PTSD who have higher psychological resilience show more advanced epigenetic aging than individuals with lower psychological resilience. We investigated whether psychological...