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Microglial ADGRG1: AD glial resilience generator
Microglial states underlying Alzheimer's disease (AD) have been well characterized in animal models and human samples, yet their regulation remains elusive. In this issue of Neuron, Zhu et al.¹ uncover Adgrg1, which governs a protective microglia phenotype through MYC activation.
BLEND: probabilistic cellular deconvolution with individualized single-cell reference integration
Cellular deconvolution estimates cell-type fractions from bulk transcriptomic data, but current methods often overlook cell type-specific expression varying across samples, discrepancies between bulk and single-cell data, or lack guidance on reference data selection and integration. Therefore, we present BLEND, a hierarchical Bayesian method that leverages multiple single-cell reference datasets to perform cellular deconvolution. BLEND estimates cellular fractions accurately by learning the most...
Past Meal-Skipping Habits Associate With Physical Frailty in Later Life: A Retrospective Cohort Study
CONCLUSIONS AND IMPLICATIONS: To prevent physical frailty in later life, acquiring regular eating habits may be important, especially in midlife.
Immune cells and inflammatory proteins are differentially associated with subsequent DNA methylation biological aging measures in the Framingham Heart Study Offspring Cohort
To gain a more comprehensive understanding of the relationships among immunoscenescence and inflammaging, and subsequent epigenetic aging, we measured a panel of 43 immune cell phenotypes and 68 inflammatory proteins collected from blood samples provided by participants in the Framingham Heart Study Offspring Cohort at Exam 7 (1998-2001) and principal component-based DNA methylation (DNAm)-based biologic clocks measured at the subsequent exam (Exam 8 2005-2008), an average of 6 years later. A...
Intercellular communication in the brain through a dendritic nanotubular network
Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite-dendrite nanotubes (DNTs) in mammalian cortex. Super-resolution microscopy in dissociated neurons revealed DNTs' actin-rich composition and dynamics, enabling long-range calcium ion (Ca^(2+)) propagation. Imaging and machine learning-based analysis validated in situ DNTs as anatomically distinct from...
m6A-mediated circG3BP1 translocation to stress granules promotes nucleation and senescence-linked chemoresistance
RNAs and RNA-binding proteins (RBPs) play crucial roles in stress granule (SG) dynamics, yet the specific interactions between SG-associated circular RNAs (circRNAs) and RBPs in esophageal squamous cell carcinoma (ESCC) remain unclear. In this study, we identified m6A-modified circG3BP1 as a potential prognostic biomarker in ESCC. Under cisplatin-induced stress, IGF2BPs facilitate the m6A-dependent translocation of circG3BP1 to SGs, where it functions as a scaffold to enhance TIAR-CAPRIN1...
Aging-rewired metabolic cues promote autophagy and senescence via DRAM1
Being a major contributor to cell senescence and aging, DNA damage activates macroautophagy/autophagy, but how this process is affected by aging-rewired metabolism in normal biological systems remains to be explored. Here in cultured human umbilical cord-derived mesenchymal stem cells (HsMSCs) and the mouse liver that accumulate DNA damage during aging, we found an elevation of DRAM1 (DNA damage regulated autophagy modulator 1) and DRAM1-mediated pro-senescent autophagy (DMPA). Confirming that...
TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation
Blood vessels exhibit a pronounced vulnerability to aging and are often at the forefront of systemic aging processes. Vascular endothelial cells, which line blood vessels and directly contact blood flow, are susceptible to damage and play a key role in vascular aging; however, the underlying mechanisms of their aging remain unclear. Here, we identify TRPM7 as a key molecule in vascular endothelial aging. Endothelial deletion of TRPM7 significantly accelerates premature vascular aging in mice....
Association of accelerated phenotypic aging, lifestyle and genetic risk with progression of cardiometabolic multimorbidity: a multi-state model analysis
We aimed to use multi-state models to assess joint impacts of lifestyle and genetic risk with phenotypic age acceleration on cardiometabolic multimorbidity (CMM) trajectory, and to further explore whether phenotypic age acceleration mediates association between lifestyle and each transitions. We conducted a prospective cohort study included 365,573 adults free of cardiometabolic diseases (CMDs) at baseline in UK Biobank. Multi-state model was used to calculate hazard ratios (HRs) and 95%...
Daily briefing: ‘A messenger of hope’ — Jane Goodall’s impact on science
These alien planets are astronomers’ favourites: here’s why
The paradox of AI accelerationism and the promise of public interest AI
Science, Volume 390, Issue 6768, October 2025.
Localized glutamine leakage drives the spatial structure of root microbial colonization
Science, Volume 390, Issue 6768, October 2025.
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
Science, Volume 390, Issue 6768, October 2025.
Persistent eastern equatorial Pacific Ocean upwelling since the warm Pliocene
Science, Volume 390, Issue 6768, October 2025.
Intercellular communication in the brain through a dendritic nanotubular network
Science, Volume 390, Issue 6768, October 2025.
A comprehensive genetic catalog of human double-strand break repair
Science, Volume 390, Issue 6768, October 2025.
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Science, Volume 390, Issue 6768, October 2025.
Lithium-ion intercalation by coupled ion-electron transfer
Science, Volume 390, Issue 6768, October 2025.