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Plasma proteomics-based organ-specific aging for all-cause mortality and cause-specific mortality: a prospective cohort study
Individual's aging rates vary across organs. However, there are few methods for assessing aging at organ levels and whether they contribute differently to mortalities remains unknown. We analyzed data from 45,821 adults in the UK Biobank, using plasma proteomics and machine learning to estimate biological ages for 12 major organs. The differences between biological age and chronological age, referred to as "age gaps," were calculated for each organ. Partial correlation analyses were used to...
Anti-obesity drug has life-changing benefits for arthritis
No abstract
Clonal dynamics after allogeneic haematopoietic cell transplantation
Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those from a donor^(1,2). Here, to quantify dynamics of long-term stem cell engraftment, we sequenced genomes from 2,824 single-cell-derived haematopoietic colonies of ten donor-recipient pairs taken 9-31 years after HLA-matched sibling HCT³. With younger donors (18-47 years at transplant), 5,000-30,000 stem cells had engrafted and were still contributing to haematopoiesis at the...
The impact of cysteine on lifespan in three model organisms: A systematic review and meta-analysis
Cysteine is an amino acid present in thiol proteins and often dictates their secondary structures. Although considered nonessential, cysteine may be essential for patients with certain metabolic diseases and can reduce the requirement for dietary methionine. Cysteine and some of its derivatives, such as N-acetylcysteine, are considered antioxidants and widely used in animal aging studies. To provide insights into the potential anti-aging effects of cysteine, we systematically reviewed and...
Arginine metabolism is a biomarker of red blood cell and human aging
Increasing global life expectancy motivates investigations of molecular mechanisms of aging and age-related diseases. This study examines age-associated changes in red blood cells (RBCs), the most numerous host cell in humans. Four cohorts, including healthy individuals and patients with sickle cell disease, were analyzed to define age-dependent changes in RBC metabolism. Over 15,700 specimens from 13,757 humans were examined, a major expansion over previous studies of RBCs in aging. Multi-omics...
Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study
CONCLUSION: These findings may suggest potential markers for cognitive decline, providing a new target for future screening.
The five biggest challenges facing misinformation researchers
The burgeoning field is still grappling with fundamental problems, from getting access to data to defining 'misinformation' in the first place
Daily briefing: Variant of mpox virus is getting better at human-to-human transmission
See a giant ‘ghost particle’ detector and more — October’s best science images
Diabetes risk soars for adults who had a sweet tooth as kids
Naked mole rats vanquish genetic ghosts — and achieve long life
Retraction Note: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype
Rejuvenating older neural stem cells
Passive materials–based solutions for cool and “radiant” cities
Science, Volume 386, Issue 6721, November 2024.
Hidden players: the bacteria-killing viruses of the gut microbiome
The seas are on the rise — and that surge is accelerating
How does overeating lead to diabetes? A surge of neurotransmitters
Exposure to sugar rationing in the first 1000 days of life protected against chronic disease
Science, Volume 386, Issue 6725, Page 1043-1048, November 2024.
In Science Journals
Science, Volume 386, Issue 6721, Page 503-506, November 2024.
Policy evaluation and the causal analysis of public support
Science, Volume 386, Issue 6721, Page 490-492, November 2024.