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1 year 1 month ago
Science, Volume 387, Issue 6732, Page 374-375, January 2025.

Corinne Simonti, and
Jesse Smith,
Sacha Vignieri,
Sarah H. Ross,
Ian S. Osborne,
Di Jiang,
Sumin Jin,
Caroline Ash, and
Jelena Stajic

Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation

1 year 1 month ago
Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing lifespan extension and enhanced mobility in Caenorhabditis elegans, accompanied by improved stress resistance and reduced age-associated biomarkers. In aged rats, ET administration enhances exercise endurance, muscle mass, and vascularization, concomitant with higher NAD^(+)...
Dunja Petrovic