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Intermittent low-intensity and moderate-intensity exercise effects on cognition in community-dwelling older adults: a pilot study exploring biological mechanisms
CONCLUSION: Moderate-intensity AE and LIM intermittent training likely have distinct cognitive benefits, though low-intensity activity is often included as a control group in exercise trials in aging.
Daily briefing: ‘Impossible’ molecules break 100-year old chemical rule
The world’s oldest tree? Genetic analysis traces evolution of iconic Pando forest
The eight obituaries of a Shanghai person
Lessons from the HEALEY adaptive platform trial in amyotrophic lateral sclerosis
Chemists make ‘impossible’ molecules that break 100-year-old bonding rule
A cytoplasmic osmosensing mechanism mediated by molecular crowding–sensitive DCP5
Science, Volume 386, Issue 6721, November 2024.
Exploring structural diversity across the protein universe with The Encyclopedia of Domains
Science, Volume 386, Issue 6721, November 2024.
A solution to the anti-Bredt olefin synthesis problem
Science, Volume 386, Issue 6721, November 2024.
A molecular mechanism for bright color variation in parrots
Science, Volume 386, Issue 6721, November 2024.
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
Science, Volume 386, Issue 6721, November 2024.
In some U.S. states, science is on the ballot
Voters are being asked to consider climate policy, trophy hunting, and other issues
Molecular mechanisms of neurofilament alterations and its application in assessing neurodegenerative disorders
Neurofilaments are intermediate filaments present in neurons. These provide structural support and maintain the size and shape of the neurons. Dysregulation, mutation, and aggregation of neurofilaments raise the levels of these proteins in the blood and cerebrospinal fluid (CSF), which are characteristic features of axonal damage and certain rare neurological diseases, such as Giant Axonal Neuropathy and Charcot-Mare-Tooth disease. Understanding the structure, dynamics, and function of...
Increased inflammation in older high-pressure glaucoma mice
Besides an elevated intraocular pressure (IOP), advanced age is one of the most crucial risk factors for developing glaucoma. βB1-Connective Tissue Growth Factor (βB1-CTGF) high-pressure glaucoma mice were used in this study to assess whether glaucoma mice display more inflammatory and aging processes than age-matched controls. Therefore, 20-month-old βB1-CTGF and corresponding wildtype (WT) controls were examined. After IOP measurements, retinas were processed for (immuno-)histological and...
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype
Senescence is a state of indefinite cell-cycle arrest associated with aging, cancer, and age-related diseases. Here, we find that translational deregulation, together with a corresponding maladaptive integrated stress response (ISR), is a hallmark of senescence that desensitizes senescent cells to stress. We present evidence that senescent cells maintain high levels of eIF2α phosphorylation, typical of ISR activation, but translationally repress production of the stress response activating...
Design and methodology of the harmonized diagnostic assessment of dementia for the longitudinal aging study in India: Wave 2
The rising burden of dementia calls for high-quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI-DAD) was designed to provide longitudinal assessments of cognition and dementia in India. All Wave 1 participants were recruited for a follow-up interview, and a refresher sample was drawn from the Longitudinal Aging Study in India, a nationally representative cohort of Indians aged 45 and older....
Alzheimer's drug approvals create prescribing dilemmas
Clinicians and patients weigh modest benefits of the antibodies against sometimes-serious side effects.
Endothelial cell-specific progerin expression does not cause cardiovascular alterations and premature death
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene that provokes the synthesis of progerin, a mutant version of the nuclear protein lamin A that accelerates aging and precipitates death. The most clinically relevant feature of HGPS is the development of cardiac anomalies and severe vascular alterations, including massive loss of vascular smooth muscle cells, increased fibrosis, and generalized atherosclerosis. However, it is unclear if...
Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan
The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized structural and cell-type-specific enrichment of stable macromolecules in both the follicular and extrafollicular environments. Moreover, ovaries and...
Neurocognitive correlates of cerebral mitochondrial function and energy metabolism using phosphorus magnetic resonance spectroscopy in older adults
The goal of the current study was to learn about the role of cerebral mitochondrial function on cognition. Based on established cognitive neuroscience, clinical neuropsychology, and cognitive aging literature, we hypothesized mitochondrial function within a focal brain region would map onto cognitive behaviors linked to that brain region. To test this hypothesis, we used phosphorous (^(31)P) magnetic resonance spectroscopy (MRS) to derive indirect markers of mitochondrial function and energy...