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Nonalloyed α-phase formamidinium lead triiodide solar cells through iodine intercalation
Science, Volume 387, Issue 6731, Page 284-290, January 2025.
Mechanically interlocked two-dimensional polymers
Science, Volume 387, Issue 6731, Page 264-269, January 2025.
Stereomicrostructure-regulated biodegradable adhesives
Science, Volume 387, Issue 6731, Page 297-303, January 2025.
Tactile edges and motion via patterned microstimulation of the human somatosensory cortex
Science, Volume 387, Issue 6731, Page 315-322, January 2025.
Reconstitution of synaptic junctions orchestrated by teneurin-latrophilin complexes
Science, Volume 387, Issue 6731, Page 322-329, January 2025.
Drought in a warmer, CO2-rich climate restricts grassland water use and soil water mixing
Science, Volume 387, Issue 6731, Page 290-296, January 2025.
Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
Science, Volume 387, Issue 6731, Page 329-336, January 2025.
Rooting out racial prejudices
Science, Volume 387, Issue 6731, Page 254-254, January 2025.
The ancestral genome’s tale
Science, Volume 387, Issue 6731, Page 253-253, January 2025.
Microscopic pillars on insect wings give bugs an antibacterial superpower
New insights into how these “nanopillars” work could inspire better ways to protect humans from infection
New materials with interlocking parts can flow like liquid or contract like muscles
Made like miniature chainmail armor, these polymers have strange—and useful—properties
Climate change may be driving spread of a deadly fungus from U.S. Southwest
Valley fever has exploded since 2000. Scientists are trying to figure out why (edited)
News at a glance: Oldest continuous ice core, formaldehyde’s risks, and building Africa’s science workforce
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The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease
Although the relationship between macroautophagy/autophagy and Alzheimer disease (AD) is widely studied, the underlying mechanisms are poorly understood, especially the regulatory role of the initiation signaling of autophagy on AD. Here, we find that the ER transmembrane protein CANX (calnexin) is a novel interaction partner of the autophagy-inducing kinase ULK1 and is required for ULK1 recruitment to the ER under basal or starved conditions. Loss of CANX results in the inactivity of ULK1...
The immunology of stroke and dementia
Ischemic stroke and vascular cognitive impairment, caused by a sudden arterial occlusion or more subtle but protracted vascular insufficiency, respectively, are leading causes of morbidity and mortality worldwide with limited therapeutic options. Innate and adaptive immunity have long been implicated in neurovascular injury, but recent advances in methodology and new experimental approaches have shed new light on their contributions. A previously unappreciated dynamic interplay of...
ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer's disease
PSEN1 E280A carrier for the APOE3 Christchurch variant (R136S) is protected against Alzheimer's disease (AD) symptoms with a distinct anatomical pattern of Tau pathology. However, the molecular mechanism accounting for this protective effect remains incompletely understood. Here, we show that the ApoE3 R136S mutant strongly binds to Tau and reduces its uptake into neurons and microglia compared with ApoE3 wild type (WT), diminishing Tau fragmentation by asparagine endopeptidase (AEP),...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
The complexity of the human brain makes it challenging to understand the molecular mechanisms underlying brain function. Genome-wide association studies have uncovered variants associated with neurological phenotypes. Single-cell transcriptomics have provided descriptions of changes brain cells undergo during disease. However, these approaches do not establish molecular mechanism. To facilitate the scalable interrogation of causal molecular mechanisms in brain cell types, we developed a 3D...