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Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

1 year 5 months ago
Stiffening of the aorta is a key antecedent to cardiovascular diseases (CVD) with aging. Age-related aortic stiffening is driven, in part, by cellular senescence-a hallmark of aging defined primarily by irreversible cell cycle arrest. In this study, we assessed the efficacy of 25-hydroxycholesterol (25HC), an endogenous cholesterol metabolite, as a naturally occurring senolytic to reverse vascular cell senescence and reduce aortic stiffness in old mice. Old (22-26 months) p16-3MR mice, a...
Sophia A Mahoney

Food-washing monkeys recognize the law of diminishing returns

1 year 5 months ago
Few animals have the cognitive faculties or prehensile abilities needed to eliminate tooth-damaging grit from food surfaces. Some populations of monkeys wash sand from foods when standing water is readily accessible, but this propensity varies within groups for reasons unknown. Spontaneous food-washing emerged recently in a group of long-tailed macaques (Macaca fascicularis) inhabiting Koram Island, Thailand, and it motivated us to explore the factors that drive individual variability. We...
Jessica E Rosien

Physical Activity Modifies the Metabolic Profile of CD4<sup>+</sup> and CD8<sup>+</sup> T-Cell Subtypes at Rest and Upon Activation in Older Adults

1 year 5 months ago
T-cell metabolism is a key regulator of immune function. Metabolic dysfunction in T cells from young mice results in an aged phenotype, accelerating immunosenescence. Physical activity (PA) maintains T-cell function and delays immunosenescence in older adults, but the underlying mechanisms are poorly understood. We investigated the effects of PA on the metabolic and functional profiles at a single-cell resolution of resting and stimulated T cells from young adults (N = 9, 23 ± 3 years) and...
Jon Hazeldine

Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer's disease

1 year 5 months ago
Alzheimer's disease (AD) is a neurodegenerative condition associated with aging. As the population ages, the incidence of AD has risen annually, making it the fourth leading cause of death, following cardiovascular disease, cancer, and stroke. The main pathological features of AD are now thought to include the accumulation of extracellular amyloid-β (Aβ) plaques, the formation of intracellular neurofibrillary tangles, and a reduction in synaptic connections in the cerebral cortex and...
Minji Zhou

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network)

1 year 5 months ago
CONCLUSION: The comprehensive clinical use of multiple laboratory biomarkers can contribute both to the early identification of trajectories of cognitive and functional decline in older adults, and to the identification of mechanisms underlying the effect of multidisciplinary interventions on age-related pathological processes.
Gessica Sala