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Rice is not as nice with global warming
Author Correction: Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability
Global warming is on the cusp of crucial 1.5 °C threshold, suggest ice-core data
The next massive volcano eruption will cause climate chaos — and we are unprepared
To boost science, the growing BRICS group must embrace inclusion and transparency
Your dissertation is your business card!
The quest to build bionic limbs that feel like the real thing
Why did Earth’s first radio message to alien civilizations leave out half of humanity?
South Korea can boost the research potential of low-income countries
‘I get paid for my outputs, not because I am Māori’: why Indigenous researchers often face double duty
Why we are all lab rats in the digital world
Worryingly high prevalence of retraction among top-cited researchers
Devastating Spanish floods expose an urgent need for more flood-risk professionals
Ignoring journal metrics on CVs is an act of privilege
Growth area: early studies exploring how tissues and cells grow
Systemic biases are leading to an intersex research void
Research advocates see ‘no good news’ in Trump’s economic, immigration agenda
Republican control of Congress will help him with agency appointments and policy shifts
Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current insights and future directions
Neurodegenerative diseases, as common diseases in the elderly, tend to become younger due to environmental changes, social development and other factors. They are mainly characterized by progressive loss or dysfunction of neurons in the central or peripheral nervous system, and common diseases include Parkinson's disease, Alzheimer's disease, Huntington's disease and so on. Mitochondria are important organelles for adenosine triphosphate (ATP) production in the brain. In recent years, a large...
GNG5 is a novel regulator of Abeta42 production in Alzheimer's disease
The therapeutic options for Alzheimer's disease (AD) are limited, underscoring the critical need for finding an effective regulator of Aβ42 production. In this study, with 489 human postmortem brains, we revealed that homotrimer G protein subunit gamma 5 (GNG5) expression is upregulated in the hippocampal-entorhinal region of pathological AD compared with normal controls, and is positively correlated with Aβ pathology. In vivo and in vitro experiments confirm that increased GNG5 significantly...