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Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model

1 year 1 month ago
Impaired sleep is a common aspect of aging and often precedes the onset of Alzheimer's disease. Here, we compare the effects of sleep deprivation in young wild-type mice and their APP/PS1 littermates, a murine model of Alzheimer's disease. After 7 h of sleep deprivation, both genotypes exhibit an increase in EEG slow-wave activity. However, only the wild-type mice demonstrate an increase in the power of infraslow norepinephrine oscillations, which are characteristic of healthy non-rapid eye...
Neža Cankar

The immune landscape of murine skeletal muscle regeneration and aging

1 year 1 month ago
Age-related alterations in the immune system are starting to emerge as key contributors to impairments found in aged organs. A decline in regenerative capacity is a hallmark of tissue aging; however, the contribution of immune aging to regenerative failure is just starting to be explored. Here, we apply a strategy combining single-cell RNA sequencing with flow cytometry, histological analysis, and functional assays to perform a complete analysis of the immune environment of the aged regenerating...
Neuza S Sousa

In Science Journals

1 year 1 month ago
Science, Volume 386, Issue 6723, Page 740-742, November 2024.

Michael Funk, and
Bianca Lopez,
Keith T. Smith,
Brent Grocholski,
Mattia Maroso,
Jake S. Yeston,
Jesse Smith,
Stella M. Hurtley,
Courtney Malo,
Michael A. Funk,
Di Jiang,
L. Bryan Ray,
Ankit Walia,
Phil Szuromi,
Ian S. Osborne,
Hannah M…

Advancing alternative methods to reduce animal testing

1 year 1 month ago
Science, Volume 386, Issue 6723, Page 724-726, November 2024.

Chad P. Nelson,
Paul Brown,
Suzanne Fitzpatrick,
Kevin A. Ford,
Paul C. Howard,
Tracy MacGill,
Edward E. C. Margerrison,
Jacqueline O’Shaughnessy,
Tucker A. Patterson,
Rakesh Raghuwanshi,
Rodney Rouse,
Selen Stromgren,
Kyung E. Sung,
Luis G…