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Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies
Science, Volume 386, Issue 6723, Page 762-767, November 2024.
Diverse and larger tree islands promote native tree diversity in oil palm landscapes
Science, Volume 386, Issue 6723, Page 795-802, November 2024.
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states
Science, Volume 386, Issue 6723, Page 802-810, November 2024.
Glaciation of liquid clouds, snowfall, and reduced cloud cover at industrial aerosol hot spots
Science, Volume 386, Issue 6723, Page 756-762, November 2024.
Synchronous recognition of amines in oxidative carbonylation toward unsymmetrical ureas
Science, Volume 386, Issue 6723, Page 776-782, November 2024.
High-temperature carbon dioxide capture in a porous material with terminal zinc hydride sites
Science, Volume 386, Issue 6723, Page 814-819, November 2024.
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
Science, Volume 386, Issue 6723, Page 768-776, November 2024.
Tomorrow’s trees
Science, Volume 386, Issue 6723, Page 733-733, November 2024.
A voyage to victory
Science, Volume 386, Issue 6723, Page 734-734, November 2024.
When it comes to science, U.S. Senate’s new leader has a buried past
Senator John Thune helped convert an abandoned South Dakota gold mine into a deep underground laboratory
With first mechanical qubit, quantum computing goes steampunk
Sapphire crystal’s vibrations used to make two-ways-at-once quantum bit
A breakthrough cancer immunotherapy is now taking aim at autoimmune disease
CAR-T therapy is generating excitement for lupus, scleroderma, and other conditions as clinical trials expand
Meet Evo, the DNA-trained AI that creates genomes from scratch
ChatGPT-like model learns on its own to devise new proteins and genetic sequences
News at a glance: Replication troubles, financial conflict disclosures, and a public health shake-up
The latest in science and policy
Why do humans mature so slowly? An ancient youth offers clues
Small-brained member of Homo that lived 1.8 million years ago may signal a step toward long, drawn-out childhoods
Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits
Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's...
Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer's Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding. Using a multivariate...
Immune responses influence sex differences in Alzheimer disease
No abstract
Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer's Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding. Using a multivariate...
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
Decline in mitochondrial function is linked to decreased muscle mass and strength in conditions like sarcopenia and type 2 diabetes. Despite therapeutic opportunities, there is limited and equivocal data regarding molecular cues controlling muscle mitochondrial plasticity. Here we uncovered that the mitochondrial mRNA-stabilizing protein SLIRP, in complex with LRPPRC, is a PGC-1α target that regulates mitochondrial structure, respiration, and mtDNA-encoded-mRNA pools in skeletal muscle. Exercise...