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Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population-based adult twin study
Several crucial acceleration periods exist during aging process. Epigenetic clocks, serving as indicators of aging, are influenced by genetic factors. Investigating how the genetic contributions on these clocks change with age may provide novel insights into the aging process. In this study, based on 1084 adult twins from the Chinese National Twin Registry (CNTR), we established structural equation models (SEMs) to evaluate the trends in genetic influence with aging for epigenetic clocks, which...
Metabolomic characterization of unintentional weight loss among community-dwelling older Black and White men and women
This study aims to understand the metabolic mechanisms of unintentional weight loss in older adults. We investigated plasma metabolite associations of subsequent weight change over 2 years in 1536 previously weight stable participants (mean age 74.6 years, 50% women, 35% Black) from the Health, Aging and Body Composition (Health ABC) Study. Multinomial logistic regressions were used to examine associations of the 442 metabolites with weight loss with/without an intention and weight gain >3%...
Editorial: Dance, embodied agency and neuroplasticity in aging
No abstract
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Understanding the pathophysiology of neurological symptoms observed after severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection is essential to optimizing outcomes and therapeutics. To date, small sample sizes and narrow molecular profiling have limited the generalizability of findings. In this study, we profiled multiple cortical and subcortical regions in postmortem brains of patients with coronavirus disease 2019 (COVID-19) and controls with matched pulmonary pathology (total...
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Understanding the pathophysiology of neurological symptoms observed after severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection is essential to optimizing outcomes and therapeutics. To date, small sample sizes and narrow molecular profiling have limited the generalizability of findings. In this study, we profiled multiple cortical and subcortical regions in postmortem brains of patients with coronavirus disease 2019 (COVID-19) and controls with matched pulmonary pathology (total...
A sample of the Moon’s far side retrieved by Chang’e-6 contains 2.83-billion-year-old basalt
Science, Volume 386, Issue 6728, Page 1395-1399, December 2024.
Daily briefing: Tech giants invest in next-generation geothermal energy
How human brains got so big: our cells learned to handle the stress that comes with size
Major biomedical funder NIH poised for massive reform under Trump 2.0
Radiation for dummies: the female mannequins testing space-travel safety
Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial
Fragments of eternal youth
Stress can disrupt memory and lead to needless anxiety — here’s how
Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts
Chemical genetic approaches to dissect microbiota mechanisms in health and disease
Science, Volume 386, Issue 6723, November 2024.
Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1
Science, Volume 386, Issue 6723, November 2024.
Sequence modeling and design from molecular to genome scale with Evo
Science, Volume 386, Issue 6723, November 2024.
SPL13 controls a root apical meristem phase change by triggering oriented cell divisions
Science, Volume 386, Issue 6723, November 2024.
A glutamine metabolic switch supports erythropoiesis
Science, Volume 386, Issue 6723, November 2024.
Saber-toothed kitten frozen in Siberian ice reveals new details about species
Ice mummy preserves extinct cat from claws to paws