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Lysosomes signal through the epigenome to regulate longevity across generations

8 months 3 weeks ago
The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways signal through the epigenome to regulate transgenerational longevity in Caenorhabditis elegans. Activation of lysosomal lipid signaling and lysosomal adenosine monophosphate-activated protein kinase (AMPK) or reduction of lysosomal mechanistic target of rapamycin (mTOR) signaling increased the...
Qinghao Zhang

Empathy in mild cognitive impairment: a preliminary clinical comparative study in Southern Switzerland using the interpersonal reactivity index (IRI) and the story-based empathy task (SET)

8 months 3 weeks ago
CONCLUSION: These findings provide preliminary evidence of early empathy-related and theory of mind alterations in MCI, supporting the inclusion of social cognition assessments in standard neuropsychological protocols. The combined use of self-report and task-based instruments may enhance early identification of socio-emotional dysfunctions and inform personalized clinical interventions. The preliminary nature of this study is mainly due to the small sample size and the heterogeneous clinical...
L Arnaud