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In Other Journals

9 months ago
Science, Volume 386, Issue 6728, Page 1360-1361, December 2024.

Corinne Simonti, and
Jesse Smith,
Sacha Vignieri,
Jake S. Yeston,
Sumin Jin,
Brad Wible,
Ekeoma Uzogara,
Madeleine Seale, and
Stella M. Hurtley

Hydrodynamic moiré superlattice

9 months ago
Science, Volume 386, Issue 6728, Page 1377-1383, December 2024.
Guoqiang Xu, Xue Zhou, Weijin Chen, Guangwei Hu, Zhiyuan Yan, Zhipeng Li, Shuihua Yang, Cheng-Wei Qiu



Upregulated excitatory amino acid transporter 1 (EAAT1) expression in the human medial temporal lobe in Alzheimer's disease

9 months ago
Alzheimer's disease (AD) is a growing health problem worldwide, particularly in the developed world due to an ageing population. Glutamate excitotoxicity plays a major role in the pathophysiology of AD, and glutamate re-uptake is controlled by excitatory amino acid transporters (EAATs). The EAAT2 isoform is the predominant transporter involved in glutamate reuptake, therefore EAAT1 has not been the focus of AD research. We investigated the layer-specific expression of EAAT1 in human medial...
Oliver W G Wood

Mitochondria-targeted oligomeric alpha-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson's disease and parkinsonism-dementia of Guam

9 months ago
Mitochondrial dysfunction is a central aspect of Parkinson's disease (PD) pathology, yet the underlying mechanisms are not fully understood. This study investigates the link between α-Synuclein (α-Syn) pathology and the loss of translocase of the outer mitochondrial membrane 40 (TOM40), unraveling its implications for mitochondrial dysfunctions in neurons. We discovered that TOM40 protein depletion occurs in the brains of patients with Guam Parkinsonism-Dementia (Guam PD) and cultured neurons...
Velmarini Vasquez