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Scientists must regain trust
Pig livers for people: US regulator greenlights first safety trial
Should I return to my home country after my PhD abroad?
Exclusive: the most-cited papers of the twenty-first century
The fight to keep big tech in check: digital researchers are in ‘David and Goliath’ battle
These are the most-cited research papers of all time
Science’s golden oldies: the decades-old research papers still heavily cited today
Africa CDC must become financially independent
Discussions of technologies’ societal impacts are still too limited
Ensuring that conferences are inclusive requires diverse organizers
CDC team that updated go-to physician reference on contraceptive science is fired
Scientists combed the literature, synthesizing evidence of safety for busy providers
Companies seek a second obesity treatment revolution—in pill form
Smaller, more easily made drugs that target GLP-1 could treat obesity and diabetes with fewer side effects
NSF scraps most outside advisory panels
Science agency will no longer get the community’s advice on programs ranging from biology to international activities
Colossal squid filmed in its natural habitat for the first time
The enigmatic predator, the heaviest known invertebrate, had never been seen alive in deep water
International students in the U.S. are reeling amid revoked visas and terminated records
The moves also affect a temporary work program heavily used by STEM graduates
Trump throws wrench into NSF’s support for new Texas supercomputer
Spending fight with Congress could force NSF to pull plug on fastest university-based machine
Gene clusters linked to insulin resistance identified in a genome-wide study of the Taiwan Biobank population
This pioneering genome-wide association study examined surrogate markers for insulin resistance (IR) in 147,880 Taiwanese individuals using data from the Taiwan Biobank. The study focused on two IR surrogate markers: the triglyceride to high-density lipoprotein cholesterol (TG:HDL-C) ratio and the TyG index (the product of fasting plasma glucose and triglycerides). We identified genome-wide significance loci within four gene clusters: GCKR, MLXIPL, APOA5, and APOC1, uncovering 197 genes...
Alzheimer disease seen through the lens of sex and gender
Alzheimer disease (AD) is a life-limiting neurodegenerative disorder that disproportionately affects women. Indeed, sex and gender are emerging as crucial modifiers of diagnostic and therapeutic pathways in AD. This Review provides an overview of the interactions of sex and gender with important developments in AD and offers insights into priorities for future research to facilitate the development and implementation of personalized approaches in the shifting paradigm of AD care. In particular,...
A gut hormone governing protein appetite and longevity
No abstract
Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan
Animals select food based on hungers that reflect dynamic macronutrient needs, but the hormonal mechanisms underlying nutrient-specific appetite regulation remain poorly defined. Here, we identify tachykinin (Tk) as a protein-responsive gut hormone in Drosophila and female mice, regulated by conserved environmental and nutrient-sensing mechanisms. Protein intake activates Tk-expressing enteroendocrine cells (EECs), driving the release of gut Tk through mechanisms involving target of rapamycin...