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Living in poverty is associated with gene expression changes in immune cells
Social factors influence health outcomes and life expectancy. Individuals living in poverty often have adverse health outcomes related to chronic inflammation that affect the cardiovascular, renal, and pulmonary systems. Negative psychosocial experiences are associated with transcriptional changes in genes associated with complex traits. However, the underlying molecular mechanisms by which poverty increases the risk of disease and health disparities are still not fully understood. To bridge the...
Identifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study
Identifying factors affecting lifespan, including genes or proteins, enables effective interventions. We prioritized potential drug targets and provided insights into biological pathways for healthy longevity by integrating Mendelian randomization, cohort, and experimental studies. We identified causal effects of tissue-specific genetic transcripts and serum protein levels on three longevity outcomes: the parental lifespan, the top 1% and 10% extreme longevity, utilizing Mendelian randomization...
The multiple mediating roles of depression and grandchild care in the relationship between social participation and cognitive function among middle-aged and elderly Chinese: an empirical study based on CHARLS 2020 data
CONCLUSION: Social participation not only directly improves cognitive function but also indirectly enhances it by reducing depression and increasing grandchild caregiving engagement among middle-aged and elderly individuals. However, while the mediating effect of grandchild care is statistically significant, its effect size remains relatively small, suggesting that its overall contribution to cognitive function should be interpreted with caution. In contrast, depression demonstrates a more...
Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies
No abstract
Longest human transplant of pig kidney fails
In latest xenotransplant test, Towana Looney’s body rejects gene-edited organ after more than 4 months
Energy Department cuts university overhead rates to 15% on research grants
Sudden move mirrors NIH cap on “indirect” costs that was ruled illegal
Daily briefing: Mysterious Taiwan fossil is Denisovan
NIH cuts triggered a host of lawsuits: <i>Nature</i>’s guide to what’s next
Liquids in a glass recover a graceful shape even after being shaken
Mystery of medieval manuscripts revealed by ancient DNA
Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments
Author Correction: Sulfide-rich continental roots at cratonic margins formed by carbonated melts
Structural pathway for PI3-kinase regulation by VPS15 in autophagy
Science, Volume 388, Issue 6743, April 2025.
A neuroimmune circuit mediates cancer cachexia-associated apathy
Science, Volume 388, Issue 6743, April 2025.
Rules of engagement for condensins and cohesins guide mitotic chromosome formation
Science, Volume 388, Issue 6743, April 2025.
The genetic architecture of and evolutionary constraints on the human pelvic form
Science, Volume 388, Issue 6743, April 2025.
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
Science, Volume 388, Issue 6743, April 2025.
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
Science, Volume 388, Issue 6743, April 2025.
Chief of NIH’s international center is latest director to lose job under Trump
Kathleen Neuzil had led the Fogarty International Center for less than 1 year
Sexual orientation, gender options cut from U.S. Ph.D. graduate survey
After adding questions to a key survey last year, the U.S. National Science Foundation is reversing course